?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+THYMOQUINONE+TERHADAP%0D%0AHISTOPATOLOGI+TRAKEA+TIKUS+PUTIH+(Rattus%0D%0Anorvegicus)+GALUR+Sprague+dawley+YANG%0D%0ADIPAPAR+ASAP+ROKOK&rft.creator=SARAH+TRIA+NOVRIZQULLAH+JOEN%2C+1518011149&rft.subject=+&rft.description=Latar+belakang%3A+Rokok+telah+menjadi+salah+satu+penyebab+kematian+terbesar+di%0D%0Adunia.+Thymoquinone+yang+merupakan+komponen+bioaktif+terbesar+dari+biji+Nigella%0D%0Asativa+dipercaya+dapat+menetralisir+radikal+bebas+pada+asap+rokok.+Penelitian+ini%0D%0Abertujuan+untuk+mengetahui+pengaruh+pemberian+thymoquinone+terhadap%0D%0Ahistopatologi+trakea+tikus+putih+galur+Sprague+dawley+yang+dipapar+asap+rokok.%0D%0AMetode%3A+Penelitian+ini+merupakan+penelitian+eksperimental+laboratorik+dengan%0D%0Adesain+post+test+only+control+group+design+dengan+menggunakan+24+ekor+tikus+putih%0D%0Agalur+Sprague+dawley+yang+dibagi+ke+dalam+4+kelompok+dan+diberi+perlakuan%0D%0Aselama+14+hari.+K1+diberi+makan+minum+biasa%2C+K2+dipapar+asap+rokok%2C+K3+dipapar%0D%0Aasap+rokok+dan+diberi+minyak+zaitun+0%2C5+ml%2C+P1+dipapar+asap+rokok+dan+diberi%0D%0Aminyak+zaitun+0%2C5+ml+serta+thymoquinone+5+mg%2FkgBB%2Fhari.%0D%0AHasil%3A+Hasil+rerata+kerusakan+histopatologi+trakea+pada+K1%3A+0%2C37%2C+K2%3A+2%2C67%2C+K3%3A%0D%0A1%2C73%2C+P1%3A+1%2C93.+Data+dianalisis+dengan+Uji+One+Way+Anova+didapatkan+p%3D0%2C001%0D%0A(p%3D0%3C05).%0D%0ASimpulan%3A+Terdapat+pengaruh+pemberian+thymoquinone+terhadap+histopatologi%0D%0Atrakea+tikus+putih+galur+Sprague+dawley+yang+dipapar+asap+rokok.%0D%0AKata+kunci%3A+Histopatologi+trakea%2C+rokok%2C+thymoquinone.%0D%0ABackground%3A+Cigarette+has+become+one+of+the+biggest+causes+of+death+in+the+world.%0D%0AThymoquinone%2C+which+is+the+largest+bioactive+component+of+Nigella+sativa+seeds%2C+is%0D%0Abelieved+to+be+able+to+neutralize+free+radicals+in+cigarette+smoke.+This+study+aims+to%0D%0Aanalyze+the+effect+of+thymoquinone+on+trachea+histopathology+of+Sprague+dawley%E2%80%99s%0D%0Awhite+rat+exposed+by+cigarette+smoke.%0D%0AMethods%3A+This+study+is+a+laboratory+experimental+with+post+test+only+control+group%0D%0Adesign+using+24+Sprague+dawley+white+rats+which+were+divided+into+4+groups+and%0D%0Awere+treated+for+14+days.+K1+was+given+regular+meal%2C+K2+was+given+cigarette+smoke%2C%0D%0AK3+was+given+cigarette+smoke+and+olive+oil+0%2C5+ml%2C+P1+was+given+cigarette+smoke%2C%0D%0Aolive+oil+0%2C5+ml%2C+and+thymoquinone+5+mg%2FkgBB%2Fday.%0D%0AResults%3A+The+average+score+of+trachea+histopathology+damage+on+K1%3A+0%2C37%2C+K2%3A%0D%0A2%2C67%2C+K3%3A+1%2C73%2C+P1%3A+1%2C93.+The+data+was+analyzed+by+One+Way+Anova+test+which+the%0D%0Aresult+is+p%3D0%2C001+(p%3D0%3C05).%0D%0AConclusion%3A+There+is+significant+effect+of+thymoquinone+on+trachea+histopathology%0D%0Aof+Sprague+dawley%E2%80%99s+white+rat+exposed+by+cigarette+smoke.%0D%0AKeywords%3A+Cigarette%2C+thymoquinone%2C+trachea+histopathology.&rft.publisher=FAKULTAS+ILMU+KEDOKTERAN&rft.date=2019&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F55926%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F55926%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F55926%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++SARAH+TRIA+NOVRIZQULLAH+JOEN%2C+1518011149++(2019)+PENGARUH+PEMBERIAN+THYMOQUINONE+TERHADAP+HISTOPATOLOGI+TRAKEA+TIKUS+PUTIH+(Rattus+norvegicus)+GALUR+Sprague+dawley+YANG+DIPAPAR+ASAP+ROKOK.++FAKULTAS+ILMU+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F55926%2F