?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+THYMOQUINONE+PADA+PARU+TIKUS+PUTIH%0D%0A(Rattus+novergicus)+GALUR+Sprague+dawley+YANG+DIPAPAR+ASAP+ROKOK%0D%0A%0D%0ABERDASARKAN+GAMBARAN+HISTOPATOLOGI&rft.creator=NADIA+EVA+ZAHARA%2C+1518011114&rft.subject=R+Medicine+(General)&rft.description=Background+%3A+In+2014%2C+Indonesia+ranked+4th+in+the+highest+cigarette+consumption%0D%0Ain+the+world.+Pulmonary+damage+due+to+inflammation+caused+by+exposure+to%0D%0Acigarettes+can+be+improved+by+utilizing+drugs+from+traditional+plants.+Nigella+sativa%0D%0AL+is+believed+to+have+an+effect+on+health+is+with+the+active+content+of+thymoquinone.%0D%0AObjective%3A+The+aim+of+the+study+was+to+determine+the+effect+of+thymoquinone+on%0D%0Arat+lungs+exposed+to+cigarette+smoke+based+on+histopathology+feature+.%0D%0AMethods+%3A+24+mice+were+divided+into+4+experimental+groups.+Group+1+(K1)+as+a%0D%0Anormal+control+was+only+given+aquades.+Group+2+(K2)+as+a+negative+control+was%0D%0Agiven+two+cigarettes+per+day.+Group+3+(K3)+as+a+positive+control+was+given+two%0D%0Acigarettes+per+day+and+after+2+hours+intervals+was+given+0.5+ml+%2F+kgBB+olive+oil.+The%0D%0Atreatment+group+(P)+is+a+treatment+group+given+with+two+cigarettes+and+after+intervals%0D%0Aof+2-4+hours+performed+thymoquninone+5+mg+%2F+kgBB+orally.+Cigarette+smoke+and%0D%0Athymoquninone+given+for+14+days.+The+lung+damage+parameters+were+seen+from%0D%0Aneutrophils+in+the+alveolar+%2C+interstitial+spaces+and+septal+thickening+based+on+Bello's%0D%0Ascoring.%0D%0AResult%3A+One+Way+Annova+test+results+showed+p+%3D+0%2C000+(p+%3C0%2C005)+and+Post+Hoc%0D%0ALSD+test+showed+significant+differences+between+groups+except+for+K3+and+P.%0D%0AConclusion+%3A+There+was+an+effect+of+giving+thymoquinone+to+rat+lungs+exposed+to%0D%0Acigarette+smoke+based+on+histopathology%0D%0AKeywords%3A+cigarettes%2C+pulmonary+histopathology%2C+thymoquinone%0D%0ALatar+belakang%3A+Tahun+2014+Indonesia+menempati+urutan+ke-4+konsumsi+rokok%0D%0Apaling+tinggi+di+dunia.+Kerusakan+paru+akibat+inflamasi+yang+disebabkan+paparan%0D%0Arokok+dapat+diperbaiki+dengan+pemanfaatan+obat+dari+tanaman+tradisional.+Salah%0D%0Asatu+tanaman+yang+dipercaya+memiliki+efek+bagi+kesehatan+adalah+Nigella+sativa%0D%0Adengan+kandungan+aktifnya+thymoquinone.%0D%0ATujuan%3A+Tujuan+penelitan+untuk+mengetahui+pengaruh+pemberian+thymoquinone%0D%0Aterhadap+paru+tikus+yang+dipapar+asap+rokok+berdasarkan+gambaran+histopatologi.%0D%0AMetode%3A+Penelitian+ini+menggunakan+24+ekor+mencit+yang+dibagi+kedalam+4%0D%0Akelompok+percobaan.+Kelompok+1+(K1)+sebagai+kontrol+normal+hanya+diberi%0D%0Aakuades.+Kelompok+2+(K2)+sebagai+kontrol+negatif%2C+diberikan+asap+rokok+dua%0D%0Abatang%2Fhari.+Kelompok+3+(K3)+sebagai+kontrol+positif+diberi+asap+rokok+dua%0D%0Abatang%2Fhari+dan+selang+2+jam+diberi+minyak+zaitun+0%2C5+ml%2FkgBB.+Kelompok%0D%0Aperlakuan+(P)+adalah+kelompok+perlakuan+coba+dengan+asap+rokok+dua+batang%2Fhari%0D%0Akemudian+selang+2%E2%80%934+jam+dilakukan+pemberian+thymoquninone+dosis+5+mg%2FkgBB%0D%0Aper+oral+Pemberian+asap+rokok+dan+thymoquninone+diberikan+selama+14+hari.%0D%0AParameter+kerusakan+paru+dilihat+dari+neutrofil+di+ruang+alveolar+dan+interstitial+dan%0D%0Apenebalan+septum+berdasarkan+skoring+Bello.%0D%0AHasil%3A+Hasil+uji+One+Way+Annova+menunjukan+p%3D0%2C000+(p%3C0%2C005)+dan+uji+Post+Hoc%0D%0ALSD+menunjukan+perbedaan+signifikan+antar+kelompok+kecuali+pada+K3+dan+P.%0D%0ASimpulan+%3A+Terdapat+pengaruh+pemberian+thymoquinone+terhadap+paru+tikus+yang%0D%0Adipapar+asap+rokok+berdasarkan+gambaran+histopatologi%0D%0AKata+kunci%3A+histopatologi+paru%2C+rokok%2C+thymoquinone&rft.publisher=FAKULTAS+ILMU+KEDOKTERAN&rft.date=2019&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F55956%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F55956%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F55956%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++NADIA+EVA+ZAHARA%2C+1518011114++(2019)+PENGARUH+PEMBERIAN+THYMOQUINONE+PADA+PARU+TIKUS+PUTIH+(Rattus+novergicus)+GALUR+Sprague+dawley+YANG+DIPAPAR+ASAP+ROKOK+BERDASARKAN+GAMBARAN+HISTOPATOLOGI.++FAKULTAS+ILMU+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F55956%2F