?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=EFEK+PEMBERIAN+MINYAK+ATSIRI+UMBI+RUMPUT+TEKI%0D%0A(Cyperus+rotundus+L.)+TERHADAP+GAMBARAN%0D%0AHISTOPATOLOGI+HEPAR+TIKUS+PUTIH%0D%0AYANG+DIINDUKSI+ALKOHOL&rft.creator=MAYA+NADIRA+YASMINE%2C+1518011186&rft.subject=+&rft.description=Background%3A+Purple+nutsedge+(Cyperus+rotundus%2C+L.)+is+one+of+the+most+common%0D%0Aplants+found+in+Indonesia.+One+of+the+content+of+purple+nutsedge+is+essential+oil%0D%0Awhich+can+be+used+as+antioxidant.+The+antioxidant+effect+of+the+purple+nutsedge%0D%0Atuber+essential+oil+can+work+effectively+to+catch+free+radicals+resulting+from%0D%0Aalcohol+metabolism+in+liver+so+that+the+liver+is+protected+from+free+radicals%0D%0Adamage.%0D%0APurpose%3A+To+find+out+the+effect+of+purple+nutsedge+tuber+(Cyperus+rotundus+L.)%0D%0Aessential+oil+towards+the+histopathology+of+alcohol-induced+white+rats+liver.%0D%0AMethod%3A+This+research+used+25+rats+which+were+divided+into+5+groups%2C+namely%0D%0Anegative+control+(K1)+that+was+given+aquades%2C+postivie+control+(K2)+that+was+given%0D%0Aonly+43%25+of+alcohol+with+a+dose+of+0%2C0116+ml%2FkgBB+peroral%2C+treatment+group+1%2C+2%2C%0D%0Aand+3+(P1%2C+P2%2C+and+P3)+that+were+given+43%25+of+alcohol+with+a+dose+of+0%2C0116%0D%0Aml%2FkgBB+oral+followed+by+essential+oils+of+purple+nutsedge+tuber+with+respective%0D%0Adose+of+0%2C025%2C+0%2C05%2C+and+0%2C1+ml+single-dose+oral+for+14+days.+On+the+15th+day%2C+the%0D%0Arats+were+terminated+and+their+livers+were+taken+for+microscopic+preparation.%0D%0AResult%3A+The+average+score+of+fatty+liver+were+K1%3D0%2C08%2C+K2%3D2%2C36%2C+P1%3D2%2C12%2C%0D%0AP2%3D1%2C68%2C+and+P3%3D1%2C48.+The+data+was+tested+with+Krustal-Wallis+test%2C+followed+by%0D%0Apost+hoc+Mann+Whitney+test+and+significant+mean+differences+were+found+between%0D%0Aall+groups%2C+except+between+K2-P1+groups.+The+most+optimal+antioxidant+effect+in%0D%0Athe+treatment+groups+was+seen+in+the+P3+group.%0D%0AConclusion%3A+There+is+an+effect+of+giving+purple+nutsedge+tuber+(Cyperus+rotundus%0D%0AL.)+essential+oil+towards+the+histopathology+of+alcohol-induced+white+rats+liver.%0D%0AKeyword%3A+antioxidant%2C+Cyperus+rotundus+L.%2C+essential+oil%2C+hepar+histopathology%2C%0D%0A%0D%0Apurple+nutsedge+tuber%0D%0ALatar+Belakang%3A+Rumput+teki+(Cyperus+rotundus+L.)+merupakan+salah+satu%0D%0Atanaman+yang+paling+banyak+ditemukan+di+Indonesia.+Salah+satu+kandungan%0D%0Arumput+teki+adalah+minyak+atsiri+yang+dapat+digunakan+sebagai+antioksidan.+Efek%0D%0Aantioksidan+minyak+atsiri+umbi+rumput+teki+ini+dapat+bekerja+efektif+untuk%0D%0Amenangkap+radikal+bebas+yang+dihasilkan+akibat+metabolisme+alkohol+didalam%0D%0Ahepar+sehingga+melindungi+hepar+dari+kerusakan+akibat+radikal+bebas.%0D%0ATujuan%3A+Untuk+mengetahui+efek+minyak+atsiri+umbi+rumput+teki+(Cyperus%0D%0Arotundus+L.)+terhadap+gambaran+histopatologi+hepar+tikus+putih+yang+diinduksi%0D%0Aalkohol.%0D%0AMetode%3A+Penelitian+ini+menggunakan+25+ekor+tikus+yang+dibagi+menjadi+5%0D%0Akelompok%2C+yaitu+kontrol+negatif+(K1)+yang+diberikan+akuades%2C+kontrol+positif+(K2)%0D%0Ayang+hanya+diberikan+alkohol+43%25+dengan+dosis+0%2C0116+ml%2FkgBB+peroral%2C%0D%0Akelompok+perlakuan+1%2C+2+dan+3+(P1%2C+P2+dan+P3)+yang+diberikan+alkohol+43%25%0D%0Adengan+dosis+0%2C0116+ml%2FkgBB+peroral+dilanjutkan+dengan+minyak+atsiri+umbi%0D%0Arumput+teki+dengan+dosis+berturut-turut+0%2C025%2C+0%2C05+dan+0%2C1+ml+dosis+tunggal%0D%0Aperoral+selama+14+hari.+Pada+hari+ke-15%2C+tikus+diterminasi+dan+hepar+tikus+diambil%0D%0Auntuk+sediaan+mikroskopis.%0D%0AHasil%3A+Rerata+skor+perlemakan+hati+yang+didapatkan+adalah+K1%3D0%2C08%2C+K2%3D2%2C36%2C%0D%0AP1%3D2%2C12%2C+P2%3D1%2C68%2C+dan+P3%3D1%2C48.+Data+diuji+dengan+uji+Kruskal-Wallis%2C+dilanjutkan%0D%0Adengan+uji+post+hoc+Mann+Whitney+dan+didapatkan+hasil+adanya+perbedaan+rerata%0D%0Ayang+bermakna+pada+semua+kelompok+kecuali+antara+kelompok+K2-P1.+Efek%0D%0Aantioksidan+paling+optimal+pada+kelompok+perlakuan+terlihat+pada+kelompok+P3.%0D%0ASimpulan%3A+Ada+efek+pemberian+minyak+atsiri+umbi+rumput+teki+(Cyperus%0D%0Arotundus+L.)+terhadap+gambaran+histopatologi+hepar+tikus+putih+yang+diinduksi%0D%0Aalkohol.%0D%0AKata+Kunci%3A+antioksidan%2C+Cyperus+rotundus+L.%2C+histopatologi+hepar%2C+minyak%0D%0A%0D%0Aatsiri%2C+umbi+rumput+teki&rft.publisher=FAKULTAS+ILMU+KEDOKTERAN&rft.date=2019&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F55995%2F1%2FABSTRAK%2520%2528ABSTRACT%2529.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F55995%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F55995%2F3%2FSKRIPSI%2520TANPA%2520PEMBAHASAN.pdf&rft.identifier=++MAYA+NADIRA+YASMINE%2C+1518011186++(2019)+EFEK+PEMBERIAN+MINYAK+ATSIRI+UMBI+RUMPUT+TEKI+(Cyperus+rotundus+L.)+TERHADAP+GAMBARAN+HISTOPATOLOGI+HEPAR+TIKUS+PUTIH+YANG+DIINDUKSI+ALKOHOL.++FAKULTAS+ILMU+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.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