?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+EKSTRAK+KULIT+BATANG+MANGROVE%0D%0A(Bruguiera+gymnorrhiza)+DALAM+PROSES+PENYEMBUHAN+LUKA+SAYAT%0D%0APADA+TIKUS+PUTIH+(Rattus+norvegicus)+GALUR+WISTAR&rft.creator=LIA+QELINA%2C+1518011031&rft.subject=+&rft.description=Background%3A+The+wound+is+demage+or+loss+of+body+tissues+due+to+a+factor+that%0D%0Adisrupt+the+body%E2%80%99s+protection+system.+These+factors+include+trauma%2C+temperature%0D%0Achanges%2C+chemicals%2C+electric+shock%2C+or+animal+bites.+Mangrove+extract+can+be+used%0D%0Afor+treatment+because+it+has+several+compunds+such+as+alkaloids%2C+flavonoids%2C%0D%0Asteroid%2C+diphenoid+dan+saponins.%0D%0AMethod%3A+This+research+is+an+experimental+study+with+research+desaign+post+tes%0D%0Aonly+control+grup+design.+Before+the+treated+white+rats+are+injured+using+a+razor%0D%0Ablade+to+a+depth+of+2+mm+and+lenght+wound+2+cm.+This+study+used+30+white+rats%0D%0Awhich+is+divided+into+five+groups%2C+the+negative+control+group+(k-)+which+was+only%0D%0Agiven+normal+saline%2C+the+positive+control+group+(k%2B)+wh+which+was+given+silver%0D%0Asulfadiazine%2C+the+firts+experimental+group+(p1)%2C+the+second+experimental+group%0D%0A(p3)+and+the+third+experimental+group+(p3)+which+were+given+mangrove+extract%0D%0Awith+20%25+concentration+respectively%2C+40%25+concentration+and+80%25+concentration.%0D%0AThis+research+was+conducted+for+14+days.%0D%0AResult%3A+The+results+obtained+there+are+differences+in+the+median+value+in+the+fifth%0D%0Agroup+with+p%3D0%2C000+(p%3C0%2C05)+at+Kruskall+Wallis+test.+In+the+post+hoc+Mann%0D%0AWhitney+test+there+were+significant+differences+between+the+group+of+20%25%0D%0Amangrove+extract+concentration%2C+40%25+concentration+and+80%25+concentration%0D%0Atowards+positive+control+group+(k%2B)+and+the+negative+control+group+(k-).+The%0D%0Amedian+score+of+each+group+systematically+is+k-+for+8%2C+k%2B+for+5%2C+p1+for+7%2C+p2+and+p3%0D%0Afor+6%0D%0AConclusion%3A+There+is+an+effect+of+giving+mangrove+bark+extract+to+the+wound%0D%0Ahealing+process+in+white+rats+but+it+is+no+more+effective+than+giving+1%25+silver%0D%0Asulfadiazine%0D%0A%0D%0AKeyword+%3A+Bruguiera+gymnorrizha%2C+mangrove+%2Cwound+healing%0D%0ALatar+Belakang%3A+Luka+adalah+rusak+atau+hilangannya+jaringan+tubuh+karena+suatu%0D%0Afaktor+yang+mengganggu+sistem+perlindungan+tubuh.+Faktor-faktor+ini+termasuk%0D%0Atrauma%2C+perubahan+suhu%2C+bahan+kimia%2C+sengatan+listrik%2C+atau+gigitan+hewan.%0D%0AEkstrak+mangrove+dapat+dimanfaatkan+untuk+pengobatan+karena+memiliki%0D%0Abeberapa+kandungan+senyawa+seperti+alkanoid%2C+flavonoid%2C+steroid%2C+difenoid+dan%0D%0Asaponin.%0D%0AMetode%3A+Pelitian+ini+merupakan+penelitian+eksperimental+murni+dengan+desain%0D%0Apenelitian+post+tes+only+control+group+desain.+Sebelum+diberi+perlakuan+tikus%0D%0Aterlebih+dahulu+dilukai+menggunakan+silet+dengan+kedalaman+luka+2+mm+dan%0D%0Apanjang+luka+2+cm.+Penelitian+ini+menggunakan+30+tikus+yang+dibagi+menjadi+lima%0D%0Akelompok+yaitu+kelompok+kontrol+negatif+(k-)+kelompok+hanya+diberi+normal%0D%0Asaline%2C+kelompok+kontrol+positif+(k%2B)+diberi+silver+sulfadiazine%2C+kelompok%0D%0Aperlakuan+satu+(p1)%2C+kelompok+perlakuan+dua+(p2)+dan+kelompok+perlakuan+tiga%0D%0A(p3)+diberi+ekstrak+mangrove+dengan+masing-masing+konsentrasi+20%25%2C%0D%0Akonsentrasi+40%25+dan+konsentrasi+80%25.+Penelitian+ini+dilakukan+selama+14+hari.%0D%0AHasil%3A+Hasil+yang+diperoleh+terdapat+perbedaan+nilai+median+pada+kelima%0D%0Akelompok+dengan+nilai+p%3D0%2C000+(p%3C0%2C05)+pada+uji+Kruskal+Wallis.+Pada+uji+post%0D%0Ahoc+Mann+Whitney+terdapat+perbedaan+signifikan+antar+kelompok+konsentrasi%0D%0Aekstrak+mangrove+20%25%2C+konsentrasi+40%25+dan+konsentrasi+80%25+terhadap+kelompok%0D%0Akontrol+positif+(k%2B)+dan+kelompok+kontrol+negatif+(k-).+Didapatkan+nilai+median%0D%0Adari+setiap+kelompok+secara+berurutan+adalah+K-+sebesar+8%2C+K%2B+sebesar+5%2C+P1%0D%0Asebesar+7%2C+P2+dan+P3+sebesar+6%0D%0ASimpulan%3A+Terdapat+pengaruh+pemberian+ekstrak+kulit+batang+mangrove%0D%0A(Buguiera+gymnorrizha)+terhadap+proses+penyembuhan+luka+sayat+pada+tikus%0D%0Aputih+(Rattus+norvegicus)+galur+wistar+namun+tidak+lebih+efektif+dibandingkan%0D%0Adengan+pemberian+silver+sulfadiazin+1%25.%0D%0AKata+kunci+%3A+Bruguiera+gymnorrizha%2C+mangrove%2C+penyembuhan+luka&rft.publisher=FAKULTAS+ILMU+KEDOKTERAN&rft.date=2019&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F56011%2F1%2F1.%2520ABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F56011%2F2%2F2.%2520SKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F56011%2F3%2F3.%2520SKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++LIA+QELINA%2C+1518011031++(2019)+PENGARUH+PEMBERIAN+EKSTRAK+KULIT+BATANG+MANGROVE+(Bruguiera+gymnorrhiza)+DALAM+PROSES+PENYEMBUHAN+LUKA+SAYAT+PADA+TIKUS+PUTIH+(Rattus+norvegicus)+GALUR+WISTAR.++FAKULTAS+ILMU+KEDOKTERAN%2C+UNIVERSITAS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