?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PERBANDINGAN+PENGARUH+EKSTRAK+DAUN+TEH+HIJAU+DENGAN%0D%0AMETFORMIN+TERHADAP+HISTOPATOLOGI+GINJAL+TIKUS%0D%0APUTIH+(Rattus+norvegicus)+GALUR+SPRAGUE+DAWLEY%0D%0A%0D%0ADENGAN+DIET+TINGGI+LEMAK&rft.creator=KEITH+SHAWN+JEFF+LINUS%2C+1418011112&rft.subject=+&rft.description=Background%3A+Peoples+who+live+in+big+cities+tend+to+have+limited+time+so+they+need%0D%0Afood+easily+and+practically.+Fast+food+restaurants+provide+convenience+and+fast%0D%0Aservice+in+serving+food+but+many+have+high+fat+content.+This+high-fat+diet+can%0D%0Acause+damage+to+body+organs%2C+especially+the+kidneys.+Metformin+and+green+tea%0D%0Ahave+the+ability+to+reduce+fat+levels+in+the+body.+The+purpose+of+this+study+was+to%0D%0Aknow+the+effect+comparison+of+green+tea+leaf+extract+with+metformin+to+kidney%0D%0A%0D%0Ahistopathology+of+white+rats+(Rattus+norvegicus)+Sprague+Dawley+strain+with+high-%0D%0Afat+diet.%0D%0A%0D%0AMethods%3A+Experimental+analytical+research+with+post+test+only+control+group%0D%0Adesign.+The+sample+in+this+study+were+25+white+rats+(Rattus+norvegicus)+divided%0D%0Ainto+5+groups%2C+that+are+control+(K)+(not+given+treatment)%2C+treatment+1+(P1)+(given%0D%0Ametformin+100mg%2FkgBW%2Fday)%2C+treatment+2+(P2)+(given+metformin+300mg%2FkgBW%0D%0A%2Fday)%2C+treatment+3+(P3)+(given+green+tea+leaf+extract+81mg%2FkgBW%2Fday)%2C+and%0D%0Atreatment+4+(P4)+(given+green+tea+leaf+extract+270mg%2FkgBW%2Fday)%2C+which+were+also%0D%0Agiven+a+high-fat+diet.+Then+surgery+is+performed+for+histopathological%0D%0Aexamination.%0D%0AResults%3A+In+this+study+the+mean+score+of+kidney+damage+in+the+K%2C+P1%2C+P2%2C+P3%2C+and%0D%0A%0D%0AP4+groups+were+2.88%2C+2.32%2C+1.84%2C+2.32%2C+and+2.08.+Then+in+the+Mann-Whitney+Post-%0D%0AHoc+test+the+p+value+between+P1+and+P2+are+0.095%2C+P1+and+P3+are+1%2C000%2C+P1+and+P4%0D%0A%0D%0Aare+0.262%2C+P2+and+P3+are+0.095%2C+P2+and+P4+are+0.268%2C+and+P3+and+P4+are+0.262.%0D%0AConclusion%3A+There+is+no+effect+comparison+of+green+tea+leaf+extract+with%0D%0Ametformin+to+kidney+histopathology+of+white+rats+(Rattus+norvegicus)+Sprague%0D%0ADawley+strain+with+high-fat+diet.%0D%0AKeywords%3A+Green+tea+leaf+extract%2C+High-fat+diet%2C+Kidney%2C+Metformin%0D%0ALatar+Belakang%3A+Masyarakat+yang+tinggal+di+kota+besar+cenderung+memiliki%0D%0Aketerbatasan+waktu+sehingga+membutuhkan+makanan+dengan+mudah+dan+praktis.%0D%0ARestoran+cepat+saji+memberikan+kemudahan+dan+pelayanan+yang+cepat+dalam%0D%0Amenyajikan+makanan+namun+banyak+memiliki+kandungan+lemak+yang+tinggi.+Diet%0D%0Atinggi+lemak+ini+dapat+membuat+kerusakan+pada+organ+tubuh+terutama+ginjal.%0D%0AMetformin+dan+teh+hijau+memiliki+kemampuan+untuk+mengurangi+kadar+lemak%0D%0Adalam+tubuh.+Tujuan+penelitian+ini+untuk+mengetahui+perbandingan+pengaruh%0D%0Aekstrak+daun+teh+hijau+dengan+metformin+terhadap+histopatologi+ginjal+tikus+putih%0D%0A(Rattus+norvegicus)+galur+Sprague+Dawley+dengan+diet+tinggi+lemak.%0D%0AMetode%3A+Penelitian+analitik+eksperimental+dengan+rancangan+post+test+only+control%0D%0Agroup+design.+Sampel+dalam+penelitian+ini+adalah+tikus+putih+(Rattus+norvegicus)%0D%0Aberjumlah+25+ekor+yang+dibagi+dalam+5+kelompok%2C+yaitu+kontrol+(tidak+diberikan%0D%0Aperlakuan)%2C+perlakuan+1+(diberikan+metformin+100mg%2FkgBB%2Fhr)%2C+perlakuan+2%0D%0A(diberikan+metformin+300mg%2FkgBB%2Fhr)%2C+perlakuan+3+(diberikan+ekstrak+daun+teh%0D%0Ahijau+81mg%2FkgBB%2Fhr)%2C+dan+perlakuan+4+(diberikan+ekstrak+daun+teh+hijau%0D%0A270mg%2FkgBB%2Fhr)%2C+yang+juga+diberikan+diet+tinggi+lemak.+Kemudian+dilakukan%0D%0Apembedahan+untuk+pemeriksaan+histopatologi.%0D%0AHasil%3A+Pada+penelitian+ini+didapatkan+rerata+skor+kerusakan+ginjal+pada+kelompok%0D%0AK%2C+P1%2C+P2%2C+P3%2C+dan+P4+adalah+2%2C88%2C+2%2C32%2C+1%2C84%2C+2%2C32%2C+dan+2%2C08.+Kemudian+pada+uji%0D%0APost-Hoc+Mann-Whitney+didapatkan+nilai+p+antara+P1+dan+P2+adalah+0%2C095%2C+P1%0D%0Adan+P3+adalah+1%2C000%2C+P1+dan+P4+adalah+0%2C262%2C+P2+dan+P3+adalah+0%2C095%2C+P2+dan+P4%0D%0Aadalah+0%2C268%2C+dan+P3+dan+P4+adalah+0%2C262.%0D%0ASimpulan%3A+Tidak+terdapat+perbandingan+pengaruh+ekstrak+daun+teh+hijau+dengan%0D%0Ametformin+terhadap+histopatologi+ginjal+tikus+putih+(Rattus+norvegicus)+galur%0D%0ASprague+Dawley+dengan+diet+tinggi+lemak.%0D%0AKata+Kunci%3A+Diet+tinggi+lemak%2C+Ekstrak+daun+teh+hijau%2C+Ginjal%2C+Metformin&rft.publisher=FAKULTAS+ILMU+KEDOKTERAN&rft.date=2019&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F56014%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F56014%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F56014%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++KEITH+SHAWN+JEFF+LINUS%2C+1418011112++(2019)+PERBANDINGAN+PENGARUH+EKSTRAK+DAUN+TEH+HIJAU+DENGAN+METFORMIN+TERHADAP+HISTOPATOLOGI+GINJAL+TIKUS+PUTIH+(Rattus+norvegicus)+GALUR+SPRAGUE+DAWLEY+DENGAN+DIET+TINGGI+LEMAK.++FAKULTAS+ILMU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