?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=IDENTIFIKASI+SINGLE+NUCLEOTIDE+POLYMORPHISM+(SNP)+PADA%0D%0AGEN+CIRCUMSPOROZOITE+PROTEIN+Plasmodium+falciparum+DARI%0D%0APENDERITA+MALARIA+DI+WILAYAH+KERJA+PUSKESMAS+HANURA%2C%0D%0A%0D%0APESAWARAN%2C+LAMPUNG&rft.creator=Diah+Balqis+Ikfi+Hidayati%2C+1518011076&rft.subject=600+Teknologi+(ilmu+terapan)&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Background%3A+Malaria+is+an+infectius+disease+caused+by+Plasmodium+sp.%0D%0APlasmodium+falciparum+is+the+most+deadly+cause.+The+treatment+for+malaria+with%0D%0AArtemisinin-based+Combination+Therapy+(ACT)+can+cause+resistance%2C+so+a+new%0D%0Aeffort+is+needed+to+reduce+the+morbidity+of+malaria.+A+better+prevention+method%0D%0Afor+preventing+malaria+is+to+use+vaccine.+The+RTS%2CS%2FAS01+vaccine+is+the+first%0D%0Ageneration+of+malaria+vaccine+that+has+been+applied+in+Ghana%2C+Kenya+and+Malawi%0D%0Asince+early+2018.+The+vaccine+consists+of+circumsporozoite+protein+antigen+and%0D%0Ahepatitis+B+antigen.+This+vaccine+has+been+shown+to+provide+partial+protection+to%0D%0Achildren+and+has+reach+efficacy+by+80%25.%0D%0AMethod%3A+This+type+of+research+is+a+descriptive+research+with+survey+design.+The%0D%0Asample+of+research+was+obtained+from+Biological+Saved+Materials+(BSM)+as+many%0D%0Aas+53+samples.+The+examination+was+performed+using+by+PCR+method+and%0D%0Afollowed+by+a+sequencing+process+to+detect+SNP.%0D%0AResult%3A+The+results+showed+that+only+16+samples+had+high+DNA+concentration%0D%0Aand+were+successfully+performed+by+PCR+with+the+results+of+electrophoresis%0D%0Ashowing+that+the+samples+had+the+same+base+pair+length+according+to+the+target%0D%0Alength+of+the+circumsporozoite+protein+gene+and+the+sequencing+results+showed%0D%0Athere+is+no+difference+in+nucleotide+base+sequences+compared+to+references+on%0D%0APf3D7+isolates+from+Gene+Bank.%0D%0AConclusion%3A+There+is+no+SNP+on+the+circumsporozite+protein+gene+in+Plasmodium%0D%0Afalciparum+from+malaria+patients+in+the+working+area+of+Primary+Health+Care%0D%0AHanura%2C+Pesawaran%2C+Lampung.%0D%0AKeyword%3A+Circumsporozoite+protein%2C+Plasmodium+falciparum.%0D%0ALatar+Belakang%3A+Malaria+merupakan+penyakit+infeksi+yang+disebabkan+oleh%0D%0Aparasit+Plasmodium+sp.+Plasmodium+falciparum+adalah+penyebab+yang+paling%0D%0Amematikan.+Pengobatan+penyakit+malaria+menggunakan+Artemisinin-based%0D%0ACombination+Therapy+(ACT)+dapat+menyebabkan+resistensi+sehingga+diperlukan%0D%0Aupaya+baru+untuk+menurunkan+angka+kesakitan+malaria.+Sebuah+metode%0D%0Apencegahan+yang+lebih+baik+untuk+mencegah+kejadian+malaria+adalah%0D%0Amenggunakan+vaksin.+Vaksin+RTS%2CS%2FAS01+merupakan+vaksin+malaria+generasi%0D%0Apertama+yang+telah+diterapkan+di+Ghana%2C+Kenya+dan+Malawi+sejak+awal+tahun%0D%0A2018.+Vaksin+tersebut+terdiri+dari+komponen+antigen+circumsporozoite+protein+dan%0D%0Ahepatitis+B.+Vaksin+ini+telah+terbukti+memberikan+perlindungan+parsial+kepada%0D%0Aanak-anak+dan+memiliki+efikasi+sebesar+80%25.%0D%0AMetode%3A+Jenis+penelitian+ini+menggunakan+rancangan+penelitian+survey+dan%0D%0Abersifat+deskriptif.+Sampel+penelitian+diperoleh+dari+Bahan+Biologi+Tersimpan%0D%0A(BBT)+sebanyak+53+sampel.+Pemeriksaan+dilakukan+dengan+menggunakan+metode%0D%0APCR+yang+dilanjutkan+dengan+proses+sekuensing+untuk+mendeteksi+adanya+SNP.%0D%0AHasil%3A+Hasil+penelitian+menunjukkan+bahwa+hanya+16+sampel+yang+memiliki%0D%0Akonsentrasi+DNA+yang+tinggi%2C+selanjutnya+sampel+tersebut+dilakukan+PCR+dengan%0D%0Ahasil+elektroforesis+menunjukkan+bahwa+seluruh+sampel+memiliki+panjang+basa%0D%0Ayang+sama+sesuai+target+panjang+gen+circumsporozoite+protein+dan+hasil%0D%0Asekuensing+tidak+menunjukkan+adanya+perbedaan+urutan+basa+nukleotida%0D%0Adibandingkan+dengan+referensi+pada+isolat+Pf3D7+dari+Gene+Bank.%0D%0AKesimpulan%3A+Tidak+terdapat+SNP+pada+gen+circumsporozoite+protein+Plasmodium%0D%0Afalciparum+dari+penderita+malaria+di+wilayah+kerja+Puskesmas+Hanura%2C+Pesawaran%2C%0D%0ALampung.%0D%0AKata+Kunci%3A+Circumsporozoite+protein%2C+Plasmodium+falciparum.&rft.publisher=FAKULTAS+ILMU+KEDOKTERAN&rft.date=2019&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F56151%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F56151%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F56151%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Diah+Balqis+Ikfi+Hidayati%2C+1518011076++(2019)+IDENTIFIKASI+SINGLE+NUCLEOTIDE+POLYMORPHISM+(SNP)+PADA+GEN+CIRCUMSPOROZOITE+PROTEIN+Plasmodium+falciparum+DARI+PENDERITA+MALARIA+DI+WILAYAH+KERJA+PUSKESMAS+HANURA%2C+PESAWARAN%2C+LAMPUNG.++FAKULTAS+ILMU+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F56151%2F