?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=SINTESIS%2C+KARAKTERISASI+DAN+UJI+AKTIVITAS+ANTIDIABETES%0D%0ASENYAWA+KOMPLEKS+Cr(III)-ASPARTAT+DAN+Cu(II)-ASPARTAT&rft.creator=DINDA+SEFTA+FIRGUNA%2C+1517011060&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=Penelitian+ini+bertujuan+untuk+mensintesis+kompleks+Cr(III)-aspartat+dan+%0D%0ACu(II)-aspartat.+Senyawa+kompleks+tersebut+disintesis+dengan+mereaksikan+%0D%0Alogam+CrCl3.6H2O+dan+CuCl2.2H2O+dengan+ligan+asam+aspartat+dan+kemudian+%0D%0Amenentukan+aktivitas+antidiabetes+dari+senyawa+kompleks+yang+diperoleh.+%0D%0AReaksi+optimum+terjadi+pada+pH+4+pada+waktu+4+jam+untuk+kompleks+Cr+dan+%0D%0Akompleks+Cu+pada+waktu+3+jam.+Hasil+sintesis+kompleks+Cr+diperoleh+padatan%0D%0Aungu+muda+sebanyak+0%2C4001+gram+dengan+rendemen+89%2C24%25+sedangkan+untuk+%0D%0Akompleks+Cu+menghasilkan+padatan+berwarna+biru+sebanyak+0%2C3095+gram+dengan+%0D%0Arendemen+95%2C90%25.+Padatan+yang+diperoleh+dikarakterisasi+menggunakan+%0D%0Aspektofotometer+IR+dan+spektrofotometer+Uv-Vis.+Hasil+pengukuran+dengan+%0D%0Aspektofotometer+IR+menghasilkan+serapan+Cr-N+dan+Cr-O+pada+bilangan+%0D%0Agelombang+548%2C48+cm-1%0D%0Adan+456%2C45+cm-1%0D%0Auntuk+kompleks+Cr+dan+untuk+kompleks+%0D%0ACu+serapan+Cu-N+dan+Cu-O+pada+bilangan+gelombang+591%2C20+cm-1%0D%0Adan+421%2C65+%0D%0Acm%0D%0A-1%0D%0A.+Hasil+pengukuran+dengan+spektrofotometer+Uv-Vis+menunjukkan+adanya+%0D%0Aserapan+pada+panjang+gelombang+408+dan+599+nm+untuk+kompleks+Cr+dan+820+%0D%0Auntuk+kompleks+Cu.+Uji+antidiabetes+menggunakan+mencit+jantan+dengan+9+%0D%0Aperlakuan+selama+21+hari.+Data+yang+diperoleh+dianalisis+secara+statistik+%0D%0Amenggunakan+ANOVA+(Analysis+of+Variance)+pada+taraf+kepercayaan+5%25+%0D%0Adilanjutkan+uji+BNT+(Beda+Nyata+Terkecil)+pada+taraf+kepercayaan+5%25+dan+%0D%0Aaktivitas+antidiabetes+dinyatakan+dalam+%25GL+(glucose+lowering).+Hasil+%0D%0Apenelitian+menunjukkan+%25GL+pada+penelitian+ini+mencapai+56%2C54%25+sampai+%0D%0A76%2C13%25.+Seluruh+sampel+perlakuan+menunjukkan+perbedaan+penurunan+kadar+%0D%0Agula+darah+yang+signifikan+(p%3C0.05)+dengan+kelompok+kontrol.%0D%0AKata+kunci%3A+Antidiabetes%2C+senyawa+kompleks.%0D%0A%0D%0AThe+purpose+of+this+research+is+to+synthesized+of+Cr(III)-aspartate+and+%0D%0ACu(II)-aspartate+complexes+was+synthesized.+The+complexes+carried+out+%0D%0Asynthesized+by+reacting+the+metal+CrCl3.6H2O+and+CuCl2.2H2O+with+aspartic+acid+%0D%0Aligands+and+than+determine+the+antidiabetic+activity+of+the+complexes+compounds+%0D%0Aobtained.+The+optimum+reaction+occurs+at+pH+4+at+4+hours+for+the+Cr+complexes%0D%0Aand+the+Cu+complexes+at+3+hours.+Cr+complexes+synthesis+results+obtained+light+%0D%0Apurple+solids+as+much+as+0.4001+grams+with+a+yield+of+89.24+%25+while+for+the+Cu+%0D%0Acomplexes+produces+blue+solids+as+much+as+0.3095+grams+with+a+yield+of+%0D%0A95.90+%25.+The+solids+obtained+were+characterized+using+an+IR+spectrophotometer+%0D%0Aand+a+Uv-Vis+spectrophotometer.+The+of+characterization+with+IR+%0D%0Aspectrophotometer+produce+Cr-N+and+Cr-O+uptake+at+wave+numbers+548.48+cm-1%0D%0Aand+456.45+cm-1%0D%0Afor+the+Cr+complexes+and+for+Cu+complexes+Cu-N+and+Cu-O+%0D%0Aabsorption+at+the+wave+number+591%2C+20+cm-1%0D%0Aand+421.65+cm-1%0D%0A.+Characterization%0D%0Awith+Uv-Vis+spectrophotometer+show+the+absorption+at+the+wavelengths+of+408+%0D%0Aand+599+nm+for+the+Cr+complexes+and+820+for+the+Cu+complexes.+Antidiabetic+%0D%0Atest+using+male+mice+with+9+treatments+for+21+days.+The+data+obtained+were+%0D%0Astatistically+analyzed+using+ANOVA+(Analysis+of+Variance)+at+5+%25+confidence+%0D%0Alevel+followed+by+LSD+(Least+Significant+Difference)+at+5+%25+confidence+level+and+%0D%0Aantidiabetic+activity+expressed+in+%25+GL+(glucose+lowering).+The+results+showed%0D%0A%25+GL+in+this+study+reached+56.54+%25+to+76.13+%25.+All+treatment+samples+showed+a+%0D%0Asignificant+decrease+in+blood+sugar+levels+(p+%3C0.05)+with+the+control+group.%0D%0AKey+words%3A+Antidiabetic%2C+complexes+compound%0D%0A%0D%0A&rft.publisher=Fakultas+Matematika+dan+Ilmu+Pengetahuan+Alam&rft.date=2019&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F56710%2F1%2Fabstrak.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F56710%2F2%2Fskripsi%2520full%2520text.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F56710%2F3%2Fskripsi%2520full%2520text%2520tanpa%2520Bab%2520pembahas.pdf&rft.identifier=++DINDA+SEFTA+FIRGUNA%2C+1517011060++(2019)+SINTESIS%2C+KARAKTERISASI+DAN+UJI+AKTIVITAS+ANTIDIABETES+SENYAWA+KOMPLEKS+Cr(III)-ASPARTAT+DAN+Cu(II)-ASPARTAT.++Fakultas+Matematika+dan+Ilmu+Pengetahuan+Alam%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F56710%2F