?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=UJI+ANTIDIABETES%0D%0ASENYAWA+KOMPLEKS+Cr(III)-alanin+DAN+Cu(II)-alanin+TERHADAP+%0D%0AMENCIT+(Mus+musculus+L.)&rft.creator=Lia+Septiani%2C+1517011076&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=Senyawa+kromium(III)+dan+tembaga(II)+telah+diketahui+mempunyai+manfaat+%0D%0Asebagai+suplemen+antidiabetes.+Pada+penelitian+ini+dilakukan+sintesis+senyawa+%0D%0Akompleks+Cr(III)+dan+Cu(II)+dengan+asam+amino+alanin+yang+bertujuan+untuk+%0D%0Amengetahui+aktivitas+antidiabetes+dari+senyawa+kompleks+yang+terbentuk.+Sintesis+%0D%0Adilakukan+dengan+mereaksikan+logam+Cr(III)+dan+Cu(II)+dengan+ligan+asam+amino+%0D%0Aalanin.+Karakterisasi+dilakukan+dengan+Spektrofotometer+IR%2C+Spektrofotometer+%0D%0AUv-Vis+dan+analisis+EDX.+Uji+antidiabetes+dilakukan+secara+in-vivo+menggunakan+%0D%0Amencit+jantan+yang+diinduksi+aloksan.+Hasil+pengukuran+dengan+Spektrofotometer%0D%0AUv-Vis+terdapat+serapan+pada+panjang+gelombang+426+nm+dan+617+nm+untuk+%0D%0A%5BCr(ala)3%5D+dan+811+nm+untuk+%5BCu(ala)2%5D.+Hasil+pengukuran+dengan+%0D%0ASpektrofotometer+IR+pada+%5BCr(ala)3%5D+menunjukkan+ikatan+Cr-O+dengan+serapan+%0D%0Apada+bilangan+gelombang+579%2C19+cm-1%0D%0Adan+ikatan+Cr-N+dengan+serapan+pada+%0D%0Abilangan+gelombang+489%2C63+cm-1%0D%0A.+Pada+%5BCu(ala)2%5D%2C+ikatan+Cr-O+dengan+serapan+%0D%0Apada+bilangan+gelombang+590%2C19+cm-1%0D%0Adan+ikatan+Cr-N+dengan+serapan+pada%0D%0Abilangan+gelombang+439%2C31+cm-1%0D%0A.+Hasil+pengukuran+dengan+EDX+diperoleh+rumus+%0D%0Aempiris+senyawa+kompleks+yaitu+C9H15N3O6Cr+dan+C6H10N2O4Cu.+Hasil+uji+%0D%0Aantidiabetes+dinyatakan+dalam+%25GL+(Glucose+Lowering)+untuk+%5BCr(ala)3%5D+dosis+50+%0D%0A%C2%B5g+sebesar+50%2C21%25%2C+dosis+100+%C2%B5g+sebesar+60%2C14%25+dan+dosis+200+%C2%B5g+sebesar+%0D%0A77%2C40%25+dan+%5BCu(ala)2%5D+dosis+50+%C2%B5g+sebesar+54%2C3%25%2C+dosis+100+%C2%B5g+sebesar+69%2C8%25+%0D%0Adan+dosis+200+%C2%B5g+sebesar+76%2C08%25.+Uji+statistik+ANOVA+diperoleh+nilai+(p%E2%89%A40%2C05)+%0D%0Ayang+menunjukkan+hasil+yang+signifikan+dalam+penurunan+kadar+gula+darah.+%0D%0ASenyawa+kompleks+%5BCr(ala)3%5D+pada+dosis+200+%C2%B5g+lebih+efektif+menurunkan+kadar+%0D%0Agula+darah+dibandingkan+dengan+%5BCu(ala)2%5D.%0D%0AKata+kunci+%3A+Antidiabetes%2C+%5BCr(ala)3%5D%2C+%5BCu(ala)2%5D.%0D%0A%0D%0AChromium(III)+and+copper(II)+compounds+have+advantage+as+antidiabetic%0D%0Asupplements.+The+purpose+of+this+research+is+to+synthesis+of+Cr(III)+and+Cu(II)+%0D%0Acomplexes+compound+with+the+alanine+amino+acid+and+than+determine+the+%0D%0Aantidiabetic+activity+of+the+complexes+compound+formed.+Synthesis+is+carried+out+%0D%0Aby+reacting+Cr(III)+and+Cu(II)+metals+with+alanine+amino+acid+ligand.+%0D%0ACharacterization+is+carried+out+by+IR+Spectrophotometer%2C+Uv-Vis+%0D%0ASpectrophotometer+and+EDX+analysis.+Antidiabetic+testing+is+carried+out+with+in+%0D%0Avivo+using+alloxan-induced+male+mice.+Characterization+with+Uv-Vis%0D%0Aspectrophotometer+have+absorption+at+wavelengths+of+426+nm+and+617+nm+for+%0D%0A%5BCr(ala)3%5D+and+811+nm+for+%5BCu(ala)2%5D.+Characterization+with+IR+spectrophotometer+%0D%0Aat+%5BCr(ala)3%5D+showed+Cr-O+bonds+with+absorption+at+wave+number+579%2C19+cm-1%0D%0Aand+%0D%0ACr-N+bonds+with+absorption+at+wave+numbers+489%2C63+cm-1%0D%0A.+In+%5BCu(ala)2%5D%2C+the+Cr-O+%0D%0Abond+with+absorption+at+wave+number+590%2C19+cm-1%0D%0Aand+Cr-N+bond+with+absorption+%0D%0Aat+wave+number+439%2C31+cm-1%0D%0A.+Characterization+with+EDX+analysis+obtained+the+%0D%0Aempirical+formula+of+complex+compounds+are+C9H15N3O6Cr+and+C6H10N2O4Cu.+%0D%0AAntidiabetic+test+results+are+stated+in+%25GL+(Glucose+Lowering)+for+%5BCr(ala)3%5D+50+%0D%0A%CE%BCg+dose+of+50%2C21%25%2C+100+%CE%BCg+dose+of+60%2C14%25+and+200+%CE%BCg+dose+of+77%2C40%25+and+%0D%0A%5BCu(ala)2%5D+50+%CE%BCg+dose+of+54%2C3%25%2C+100+%CE%BCg+dose+of+69%2C8%25+and+200+%CE%BCg+dose+of+%0D%0A76%2C08%25.+ANOVA+statistical+test+obtained+value+(p%E2%89%A40.05)+which+showed+%0D%0Asignificant+results+in+reduction+blood+sugar+levels.+Complexes+compound+%0D%0A%5BCr(ala)3%5D+at+200+%C2%B5g+dose+is+more+effective+in+reducing+blood+sugar+levels+%0D%0Acompared+with+%5BCu(ala)2%5D.%0D%0AKeywords+%3A+Antidiabetic%2C+%5BCr(ala)3%5D%2C+%5BCu(ala)2%5D&rft.publisher=Fakultas+Matematika+dan+Ilmu+Pengetahuan+Alam&rft.date=2019&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F57044%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F57044%2F2%2FSkripsi%2520Full.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F57044%2F3%2FSkripsi%2520Full%2520tanpa%2520Bab%2520Pembahasan.pdf&rft.identifier=++Lia+Septiani%2C+1517011076++(2019)+UJI+ANTIDIABETES+SENYAWA+KOMPLEKS+Cr(III)-alanin+DAN+Cu(II)-alanin+TERHADAP+MENCIT+(Mus+musculus+L.).++Fakultas+Matematika+dan+Ilmu+Pengetahuan+Alam%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F57044%2F