@misc{eprints57098,
           title = {SINTESIS, KARAKTERISASI, DAN UJI BIOAKTIVITAS 
ANTIMALARIA SENYAWA TRIFENILTIMAH(IV) 3-AMINOBENZOAT 
DAN TRIFENILTIMAH(IV) 4-AMINOBENZOAT TERHADAP PARASIT 
Plasmodium falciparum SECARA IN VITRO},
          author = {1517011087 MONA DWI FENSKA },
         address = {UNIVERSITAS LAMPUNG},
       publisher = {Fakultas Matematika dan Ilmu Pengetahuan Alam},
            year = {2019},
             url = {http://digilib.unila.ac.id/57098/},
        abstract = {Penyakit malaria hingga saat ini belum dapat diatasi dan masih menjadi ancaman serius 
dikarenakan munculnya resistensi Plasmodium terhadap obat-obatan antibiotik. 
Berbagai upaya terus dilakukan termasuk salah satunya dengan melakukan penelitian 
terhadap obat-obatan potensial berbasis logam sebagai agen antimalaria seperti
senyawa kompleks organotimah(IV) aminobenzoat. Penelitian ini bertujuan untuk 
mendapatkan senyawa kompleks trifeniltimah(IV) 3-aminobenzoat dan 
trifeniltimah(IV) 4-aminobenzoat serta menguji efektivitas antimalaria kedua senyawa 
tersebut terhadap parasit Plasmodium falciparum secara in-vitro. Penelitian ini 
dilakukan dengan cara mereaksikan senyawa trifeniltimah(IV) hidroksida sebagai 
senyawa awal dengan ligan asam aminobenzoat. Senyawa hasil sintesis dikarakterisasi 
menggunakan spektrofotometer IR, UV-Vis, 
1H dan 13C NMR serta microelemental 
analyzer. Produk hasil sintesis berupa serbuk berwarna putih dengan nilai persen 
rendemen berturut-turut sebesar 88,81 dan 89,37\%. Senyawa hasil sintesis selanjutnya 
digunakan untuk pengujian efektivitas antimalaria dan menghasilkan nilai IC50 secara 
berurutan yaitu 0,27 dan 0,64 {\ensuremath{\mu}}g/mL. Hasil ini menunjukkan bahwa kedua senyawa 
yang disintesis bersifat aktif sebagai antimalaria karena nilai IC50 yang dihasilkan 
kurang dari 5 {\ensuremath{\mu}}g/mL. Akan tetapi jika dibandingkan terhadap klorokuin sebagai kontrol 
positif dengan nilai IC50 sebesar 0,002 {\ensuremath{\mu}}g/mL, maka aktivitas antimalaria kedua 
senyawa tersebut belum efektif. 
Kata kunci: antimalaria, Plasmodium falciparum, trifeniltimah(IV) hidroksida, 
trifeniltimah(IV) 3-aminobenzoat, trifeniltimah(IV) 4-aminobenzoat

To date, malarial diseases have not been overcome and still become a serious problem 
due to the resistence of Plasmodium toward the antibiotics medicine. Various attempts 
are continued to be done, including by doing the research and development associated 
with metal-based medicine as an antimalarial agent, for instance organotin(IV) 
aminobenzoate complex. Furthermore, the goals of this research were to get the 
triphenyltin(IV) 3-aminobenzoate and triphenyltin(IV) 4-aminobenzoate and to 
examine the effectivity of both compounds toward the Plasmodium falciparum
parasites through in vitro method. In this research, the synthesis of triphenyltin(IV) 3-
aminobenzoate and triphenyltin(IV) 4-aminobenzoate compounds by reacting the 
triphenyltin(IV) hydroxide as a precursor with aminobenzoate acid ligands has been 
done successfully. Afterwards, the synthesized compounds were characterized using 
IR, UV-Vis, 1H and 13C NMR spectrophotometer as well as microelemental analyzers. 
The synthesized compounds produced white-coloured powders with a consecutive 
yield percent value of 88.81 and 89.37\% respectively. The subsequent synthesis of the 
compounds was conducted antimalarial test and produced the IC50 equal to 0.27 and 
0.64 {\ensuremath{\mu}}g/mL respectively. It can be concluded that both compounds were active as an
antimalarial agent because the value of IC50 produced were less than 5 {\ensuremath{\mu}}g/mL. 
However, compared to chloroquine as a positive control with a value of IC50 was 0.002 
{\ensuremath{\mu}}g/mL, the antimalarial activity of both compounds was less effective.
Keywords: antimalarial, plasmodium falciparum, triphenyltin(IV) hidroxide, 
triphenyltin(IV) 3-aminobenzoate, triphenyltin(IV) 4-aminobenzoate.
}
}