?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=SINTESIS%2C+KARAKTERISASI%2C+DAN+UJI+BIOAKTIVITAS+%0D%0AANTIMALARIA+SENYAWA+TRIFENILTIMAH(IV)+3-AMINOBENZOAT+%0D%0ADAN+TRIFENILTIMAH(IV)+4-AMINOBENZOAT+TERHADAP+PARASIT+%0D%0APlasmodium+falciparum+SECARA+IN+VITRO&rft.creator=MONA+DWI+FENSKA+%2C+1517011087&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=Penyakit+malaria+hingga+saat+ini+belum+dapat+diatasi+dan+masih+menjadi+ancaman+serius+%0D%0Adikarenakan+munculnya+resistensi+Plasmodium+terhadap+obat-obatan+antibiotik.+%0D%0ABerbagai+upaya+terus+dilakukan+termasuk+salah+satunya+dengan+melakukan+penelitian+%0D%0Aterhadap+obat-obatan+potensial+berbasis+logam+sebagai+agen+antimalaria+seperti%0D%0Asenyawa+kompleks+organotimah(IV)+aminobenzoat.+Penelitian+ini+bertujuan+untuk+%0D%0Amendapatkan+senyawa+kompleks+trifeniltimah(IV)+3-aminobenzoat+dan+%0D%0Atrifeniltimah(IV)+4-aminobenzoat+serta+menguji+efektivitas+antimalaria+kedua+senyawa+%0D%0Atersebut+terhadap+parasit+Plasmodium+falciparum+secara+in-vitro.+Penelitian+ini+%0D%0Adilakukan+dengan+cara+mereaksikan+senyawa+trifeniltimah(IV)+hidroksida+sebagai+%0D%0Asenyawa+awal+dengan+ligan+asam+aminobenzoat.+Senyawa+hasil+sintesis+dikarakterisasi+%0D%0Amenggunakan+spektrofotometer+IR%2C+UV-Vis%2C+%0D%0A1H+dan+13C+NMR+serta+microelemental+%0D%0Aanalyzer.+Produk+hasil+sintesis+berupa+serbuk+berwarna+putih+dengan+nilai+persen+%0D%0Arendemen+berturut-turut+sebesar+88%2C81+dan+89%2C37%25.+Senyawa+hasil+sintesis+selanjutnya+%0D%0Adigunakan+untuk+pengujian+efektivitas+antimalaria+dan+menghasilkan+nilai+IC50+secara+%0D%0Aberurutan+yaitu+0%2C27+dan+0%2C64+%CE%BCg%2FmL.+Hasil+ini+menunjukkan+bahwa+kedua+senyawa+%0D%0Ayang+disintesis+bersifat+aktif+sebagai+antimalaria+karena+nilai+IC50+yang+dihasilkan+%0D%0Akurang+dari+5+%CE%BCg%2FmL.+Akan+tetapi+jika+dibandingkan+terhadap+klorokuin+sebagai+kontrol+%0D%0Apositif+dengan+nilai+IC50+sebesar+0%2C002+%CE%BCg%2FmL%2C+maka+aktivitas+antimalaria+kedua+%0D%0Asenyawa+tersebut+belum+efektif.+%0D%0AKata+kunci%3A+antimalaria%2C+Plasmodium+falciparum%2C+trifeniltimah(IV)+hidroksida%2C+%0D%0Atrifeniltimah(IV)+3-aminobenzoat%2C+trifeniltimah(IV)+4-aminobenzoat%0D%0A%0D%0ATo+date%2C+malarial+diseases+have+not+been+overcome+and+still+become+a+serious+problem+%0D%0Adue+to+the+resistence+of+Plasmodium+toward+the+antibiotics+medicine.+Various+attempts+%0D%0Aare+continued+to+be+done%2C+including+by+doing+the+research+and+development+associated+%0D%0Awith+metal-based+medicine+as+an+antimalarial+agent%2C+for+instance+organotin(IV)+%0D%0Aaminobenzoate+complex.+Furthermore%2C+the+goals+of+this+research+were+to+get+the+%0D%0Atriphenyltin(IV)+3-aminobenzoate+and+triphenyltin(IV)+4-aminobenzoate+and+to+%0D%0Aexamine+the+effectivity+of+both+compounds+toward+the+Plasmodium+falciparum%0D%0Aparasites+through+in+vitro+method.+In+this+research%2C+the+synthesis+of+triphenyltin(IV)+3-%0D%0Aaminobenzoate+and+triphenyltin(IV)+4-aminobenzoate+compounds+by+reacting+the+%0D%0Atriphenyltin(IV)+hydroxide+as+a+precursor+with+aminobenzoate+acid+ligands+has+been+%0D%0Adone+successfully.+Afterwards%2C+the+synthesized+compounds+were+characterized+using+%0D%0AIR%2C+UV-Vis%2C+1H+and+13C+NMR+spectrophotometer+as+well+as+microelemental+analyzers.+%0D%0AThe+synthesized+compounds+produced+white-coloured+powders+with+a+consecutive+%0D%0Ayield+percent+value+of+88.81+and+89.37%25+respectively.+The+subsequent+synthesis+of+the+%0D%0Acompounds+was+conducted+antimalarial+test+and+produced+the+IC50+equal+to+0.27+and+%0D%0A0.64+%CE%BCg%2FmL+respectively.+It+can+be+concluded+that+both+compounds+were+active+as+an%0D%0Aantimalarial+agent+because+the+value+of+IC50+produced+were+less+than+5+%CE%BCg%2FmL.+%0D%0AHowever%2C+compared+to+chloroquine+as+a+positive+control+with+a+value+of+IC50+was+0.002+%0D%0A%CE%BCg%2FmL%2C+the+antimalarial+activity+of+both+compounds+was+less+effective.%0D%0AKeywords%3A+antimalarial%2C+plasmodium+falciparum%2C+triphenyltin(IV)+hidroxide%2C+%0D%0Atriphenyltin(IV)+3-aminobenzoate%2C+triphenyltin(IV)+4-aminobenzoate.%0D%0A&rft.publisher=Fakultas+Matematika+dan+Ilmu+Pengetahuan+Alam&rft.date=2019&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F57098%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F57098%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F57098%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++MONA+DWI+FENSKA+%2C+1517011087++(2019)+SINTESIS%2C+KARAKTERISASI%2C+DAN+UJI+BIOAKTIVITAS+ANTIMALARIA+SENYAWA+TRIFENILTIMAH(IV)+3-AMINOBENZOAT+DAN+TRIFENILTIMAH(IV)+4-AMINOBENZOAT+TERHADAP+PARASIT+Plasmodium+falciparum+SECARA+IN+VITRO.++Fakultas+Matematika+dan+Ilmu+Pengetahuan+Alam%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F57098%2F