?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=SINTESIS+SENYAWA+KOMPLEKS+Cr(III)+DAN+Cu(II)+DENGAN+%0D%0AFENILALANIN+SERTA+UJI+BIOAKTIVITASNYA+SEBAGAI+SENYAWA+%0D%0AANTIDIABETES&rft.creator=RENI+WULANDARI%2C+1517011029&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=Diabetes+mellitus+merupakan+penyakit+yang+banyak+terjadi+di+Indonesia.+Penyakit+%0D%0Aini+ditandai+dengan+peningkatan+kadar+glukosa+dalam+darah+akibat+gangguan+%0D%0Asekresi+insulin.+Berbagai+upaya+mengatasi+penyakit+ini+terus+dilakukan+dengan+%0D%0Amengembangkan+obat-obatan+berbasis+logam+sebagai+antidiabetes%2C+seperti+%0D%0Asenyawa+kompleks+%5BCr(phe)3%5D+dan+%5BCu(phe)2%5D.+Penelitian+ini+bertujuan+untuk+%0D%0Amendapatkan+senyawa+kompleks+%5BCr(phe)3%5D+dan+%5BCu(phe)2%5D%2C+serta+menguji+%0D%0Abioaktivitasnya+terhadap+kadar+glukosa+dalam+darah.+Metode+ini+dilakukan+%0D%0Adengan+mensintesis+logam+kromium+dan+tembaga+dengan+ligan+fenilalanin%0D%0Amenggunakan+metode+refluks+dan+freezdryer.+Hasil+sintesis+dikarakterisasi+%0D%0Amenggunakan+spektrofotometer+UV-Vis+dan+spektrofotometer+IR.+Hasil+sintesis+%0D%0Akedua+senyawa+tersebut+merupakan+padatan+berwarna+ungu+dan+biru+dengan+nilai+%0D%0Apersen+rendemen+berturut-turut+71%2C69%25+dan+73%2C97%25.+Senyawa+hasil+sintesis+%0D%0Adilanjutkan+dengan+pengujian+aktivitas+antidiabetes+secara+in-vivo.+Data+yang+%0D%0Adiperoleh+diuji+menggunakan+One-Way+ANOVA+dan+dilanjutkan+dengan+BNT+%0D%0Apada+taraf+nyata+5%25%2C+dan+diperoleh+hasil+signifikan+yaitu+p%3C0%2C05.+Pemberian+dosis+%0D%0Asenyawa+kompleks+%5BCr(phe)3%5D+yang+paling+baik+pada+dosis+150+%CE%BCg%2FKgBB+yang%0D%0Adapat+menurunkan+kadar+glukosa+darah+mencit+sebesar+76%2C32%25+(92%2C00+%C2%B1+8%2C18ab)%2C+%0D%0Asedangkan+pemberian+dosis+senyawa+kompleks+%5BCu(phe)2%5D+yang+paling+baik+pada+%0D%0Adosis+50+%CE%BCg%2FKgBB+yang+dapat+menurunkan+kadar+glukosa+darah+mencit+sebesar+%0D%0A71%2C17%25+(98%2C00+%C2%B1+16%2C81ab).+Kompleks+%5BCr(phe)3%5D+dan+%5BCu(phe)2%5D+terbukti+dapat+%0D%0Amenurunkan+kadar+glukosa+darah+sehingga+dapat+digunakan+sebagai+senyawa+%0D%0Aantidiabetes.%0D%0AKata+kunci+%3A+Diabetes+mellitus%2C+kromium%2C+tembaga%2C+fenilalanin%2C+kadar+glukosa+darah.%0D%0A%0D%0ADiabetes+mellitus+is+a+disease+that+often+occurs+in+Indonesia.+This+disease+was%0D%0Acharacterized+by+an+increase+in+blood+glucose+levels+due+to+impaired+insulin+%0D%0Asecretion.+Various+attempts+to+evercome+this+disease+continue+to+be+done+by+%0D%0Adeveloping+metal-based+drugs+as+an+antidiabetic%2C+for+instance+%5BCr(phe)3%5D+and+%0D%0A%5BCu(phe)2%5D+complex+compounds.+The+purpose+of+this+research%2C+the+synthesis+of+%0D%0A%5BCr(phe)3%5D+and+%5BCu(phe)2%5D+complex+compounds%2C+and+test+their+bioactivity+for+%0D%0Aglucose+levels+in+the+blood.+This+method+is+carried+out+by+synthesizing+chromium+%0D%0Aand+copper+metals+with+phenylalanine+ligands+using+the+reflux+and+freezdryer+%0D%0Amethods.+The+synthesis+results+were+characterized+using+UV-Vis+%0D%0Aspectrophotometer+and+IR+spectrophotometer.+The+synthesis+results+of+two+%0D%0Acompounds+are+purple+and+blue+solids+with+a+yield+value+of+71.69%25+and+73.97%25.+%0D%0AThe+synthesized+compound+is+continued+with+in-vivo+antidiabetic+activity+testing.+%0D%0AThe+data+obtained+were+tested+using+One-Way+ANOVA+and+continued+with+BNT+%0D%0Aat+5%25+significance+results+(p%3C0.05).+The+best+dose+of+complex+compound+%0D%0A%5BCr(phe)3%5D+at+a+dose+of+150+%C2%B5g%2FkgBB+which+can+reduce+blood+glucose+levels+in+%0D%0Amice+by+76.32%25+(92.00+%C2%B18.18ab)%2C+while+the+best+dose+of+complex+compound+%0D%0A%5BCu(phe)2%5D+at+a+dose+of+50+%C2%B5g%2FkgBB+which+can+reduce+blood+glucose+levels+in+%0D%0Amice+by+71.17%25+(98.00+%C2%B1+16.81ab).+Complexes+%5BCr(phe)3%5D+and+%5BCu(phe)2%5D+are+%0D%0Aproven+to+reduce+blood+glucose+levels+so+that+they+can+be+used+as+antidiabetic+%0D%0Acompounds.%0D%0AKeywords+%3A+Diabetes+mellitus%2C+chromium%2C+copper%2C+phenylalanine%2C+blood+glucose+%0D%0A+level.%0D%0A%0D%0A&rft.publisher=Fakultas+Matematika+dan+Ilmu+Pengetahuan+Alam&rft.date=2019&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F57116%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F57116%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F57116%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++RENI+WULANDARI%2C+1517011029++(2019)+SINTESIS+SENYAWA+KOMPLEKS+Cr(III)+DAN+Cu(II)+DENGAN+FENILALANIN+SERTA+UJI+BIOAKTIVITASNYA+SEBAGAI+SENYAWA+ANTIDIABETES.++Fakultas+Matematika+dan+Ilmu+Pengetahuan+Alam%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F57116%2F