?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=ENKAPSULASI+ARTEMISININ+DENGAN+PENYALUT%0D%0AMIKROPARTIKEL+KITOSAN+%E2%80%93+TRIPOLIFOSFAT%0D%0ASEBAGAI+OBAT+ANTIMALARIA&rft.creator=Siska+Sari+Marvita%2C+1517011048&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=Artemisinin+merupakan+obat+antimalaria+yang+berasal+dari+tanaman+Artemisia%0D%0Aannua+L.+Artemisinin+memiliki+kelarutan+yang+rendah+dan+efek+initial+burst%0D%0A(pelepasan+obat+yang+kurang+baik).+Pada+penelitian+ini+dilakukan+enkapsulasi%0D%0Aartemisinin+dengan+mikropartikel+kitosan-TPP+perbandingan+1%3A1%2C+2%3A1%2C+dan+1%3A2.%0D%0AEnkapsulasi+artemisinin+dilakukan+dengan+menggunakan+homogenizer+kecepatan%0D%0A10.000+rpm%2C+karena+memberikan+ukuran+partikel+lebih+kecil+daripada%0D%0Amenggunakan+magnetik+stirrer+kecepatan+100+rpm%2C+dan+dilakukan+penambahan%0D%0A3%25+tween+80+untuk+meningkatkan+penjerapan+obat.+Ukuran+partikel%0D%0Amikroenkapsulasi+artemisinin+yang+diperoleh+sekitar+30%2C46%E2%80%9360%2C04+%CE%BCm.+Uji%0D%0Aefesiensi+mikroenkapsulasi+tertinggi+sebesar+96%2C73%25.+Berdasarkan+uji+kelarutan%2C%0D%0Akonsentrasi+artemisinin+yang+terlarut+setelah+dienkapsulasi+mengalami%0D%0Apeningkatan+mencapai+sekitar+2%2C23mg%2FL.+Berdasarkan+uji+disolusi%2C+pelepasan+obat%0D%0Aselama+3+jam+dari+artemisinin+murni+sebesar+19%2C80%25%2C+dan+mikroenkapsulasi+yang%0D%0Amemiliki+pelepasan+obat+terbaik+selama+3+jam+ditunjukkan+oleh+perbandingan%0D%0Akitosan-TPP+1%3A1+yaitu+sebesar+81%2C82%25.+Keberadaan+artemisinin+dalam%0D%0Amikroenkapsulasi+ditunjukkan+dengan+spektrum+Infrared+(IR).+Berdasarkan+hasil%0D%0Aanalisis+Scanning+Electron+Microscopy+(SEM)%2C+bentuk+morfologi%0D%0Amikroenkapsulasi+berupa+gumpalan+bulat+tidak+sempurna+dan+tidak+teratur%2C+ini%0D%0Amenunjukkan+bahwa+obat+telah+terenkapsulasi.%0D%0AKata+Kunci+%3A+Artemisinin%2C+mikropartikel+Kitosan-TPP%2C+Enkapsulasi%2C%0D%0AKelarutan%2C+Disolusi.%0D%0A%0D%0AArtemisinin+is+an+antimalarial+drug+derived+from+the+Artemisia+annua+L+plant.+Artemisinin+has+a+low+solubility+and+an+initial+burst+effect+(lack+of+drug+release).%0D%0AIn+this+study%2C+artemisinin+was+encapsulated+with+chitosan-TPP+microparticles+in+a%0D%0Aratio+of+1%3A1%2C+2%3A1%2C+and+1%3A2+respectively.+Artemisinin+encapsulation+was+carried+out%0D%0Ausing+a+homogenizer+at+10%2C000+rpm%2C+because+it+give+smaller+particle+size+than%0D%0Amagnetic+stirrer+at+100+rpm%2C+and+the+addition+of+3%25+tween+80+to+increase+drug%0D%0Aabsorption.+The+artemisinin+microencapsulation+particle+size+obtained+was+around%0D%0A30.46-60.04+%CE%BCm.+The+highest+microencapsulation+efficiency+test+was+96.73%25.%0D%0ABased+on+the+solubility+test%2C+the+concentration+of+artemisinin+dissolved+after%0D%0Aencapsulation+has+increased+to+around+2.23+mg%2FL.+According+to+the+dissolution%0D%0Atest%2C+drug+release+from+pure+artemisinin+for+3+hours+was+19.80%25%2C+and%0D%0Amicroencapsulation+which+has+the+best+drug+release+for+3+hours+was+indicated+by%0D%0AChitosan-TPP+ratio+of+1%3A1+namely+81.82%25.+The+presence+of+artemisinin+in%0D%0Amicroencapsulation+was+indicated+by+the+Infrared+(IR)+spectrum.+Based+on+the%0D%0Aresults+of+the+Scanning+Electron+Microscopy+(SEM)+analysis%2C+the+morphological%0D%0Aform+of+microencapsulation+in+the+form+of+lumps+was+imperfect+and+irregular%2C+this%0D%0Ashowed+that+the+drug+has+been+encapsulated.%0D%0AKeywords%3A+Artemisinin%2C+Chitosan-TPP+microparticles%2C+Encapsulation%2C+Solubility%2C%0D%0ADissolution.%0D%0A%0D%0A&rft.publisher=Fakultas+Matematika+dan+Ilmu+Pengetahuan+Alam&rft.date=2019&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F57141%2F1%2FAbstrak.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F57141%2F2%2FSkripsi%2520full%2520teks.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F57141%2F3%2FSkripsi%2520full%2520teks%2520tanpa%2520Bab%2520Pembahasan.pdf&rft.identifier=++Siska+Sari+Marvita%2C+1517011048++(2019)+ENKAPSULASI+ARTEMISININ+DENGAN+PENYALUT+MIKROPARTIKEL+KITOSAN+%E2%80%93+TRIPOLIFOSFAT+SEBAGAI+OBAT+ANTIMALARIA.++Fakultas+Matematika+dan+Ilmu+Pengetahuan+Alam%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F57141%2F