?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=POTENSI+EKSTRAK+METANOL+DAUN+JERUJU+(Acanthus+ilicifolius+L.)%0D%0ADAN+LAMUN+(Enhalus+acoroides)+SEBAGAI+AGEN+KEMOPREVENTIF%0D%0ATERHADAP+ONKOGENESIS+PADA+PARU-PARU+MENCIT%0D%0A(Mus+musculus+L.)+YANG+DIINDUKSI+SENYAWA+POLISIKLIK%0D%0AAROMATIK+HIDROKARBON+(PAH)%0D%0A&rft.creator=Yonathan+Christyanto%2C+1517021151&rft.subject=570+Biologi&rft.description=Polycyclic+aromatic+hydrocarbons+(PAH)+are+carcinogenic+compounds+that+can%0D%0Ainitiate+oncogenesis%2C+one+of+which+is+Benzo(a)pyrene+or+BaP.+Some+coastal+plants%0D%0Asuch+as+jeruju+and+lamun+are+thought+to+have+secondary+metabolites+which+have%0D%0Athe+potential+to+prevent+oncogenesis+occur+before+the+clinical+symptoms%2C+cancer.%0D%0AIn+this+study%2C+it+is+expected+that+secondary+metabolites+present+in+these+two+plants%0D%0Acan+have+the+potential+to+be+chemopreventive+agents+for+oncogenesis+in+the+lungs%0D%0Aof+mice+and+have+the+same+effectiveness+as+taurine+which+has+the+ability+as+an%0D%0Aanticancer.+This+study+was+conducted+using+a+completely+randomized+design+with%0D%0Afive+treatment+groups%2C+each+of+five+replications.+Group+I+as+a+negative+control+that%0D%0Ais+not+given+treatment.+Group+II+as+a+positive+control%2C+induced+by+BaP+without%0D%0Abeing+given+test+material.+Group+III+was+given+taurine+at+a+dose+of+15.6+mg%2Fmice%0D%0Aafter+BaP+induction.+Group+IV+was+given+methanol+extract+of+jeruju+leaves+at+a%0D%0Adose+of+22.4+mg%2Fmice+after+BaP+induction.+Group+V+was+given+methanol+extract%0D%0Aof+lamun+at+a+dose+of+8.7+mg%2Fmice+after+BaP+induction.+BaP+induction+with+a+dose%0D%0Aof+0.3+mg%2Fmice+was+administered+for+10+days%2C+then+the+test+material+was%0D%0Aadministered+for+15+days.+Data+obtained+were+analyzed+by+ANOVA+and%0D%0Acontinued+with+LSD+test+at+5%25+level.+The+results+obtained+show+that+the%0D%0Aadministration+of+test+materials+can+maintain+the+number+of+erythrocytes+and%0D%0Aleukocytes+in+the+normal+range+and+significantly+reduce+the+lung+tissue+damage+of%0D%0Amice+due+to+BaP+induction%2C+with+the+order+from+the+most+effective+are+taurine%2C%0D%0Ajeruju+leaf+extract%2C+and+last%2C+seagrass+extract.%0D%0AKey+words+%3A+jeruju%2C+lamun%2C+lungs%2C+oncogenesis%2C+PAH%0D%0AOleh%0D%0AYonathan+Christyanto%0D%0APolisiklik+aromatik+hidrokarbon+(PAH)+merupakan+senyawa+karsinogenik+yang%0D%0Adapat+memulai+terjadinya+onkogenesis%2C+salah+satunya+yaitu+Benzo(a)piren+atau%0D%0ABaP.+Beberapa+tumbuhan+pesisir+seperti+jeruju+dan+lamun+diduga+memiliki%0D%0Akandungan+metabolit+sekunder+yang+berpotensi+untuk+mencegah+berlangsungnya%0D%0Aonkogenesis+sebelum+timbulnya+gejala+klinis%2C+yaitu+kanker.+Maka%2C+dalam%0D%0Apenelitian+ini+diharapkan+senyawa+metabolit+sekunder+yang+ada+pada+kedua%0D%0Atanaman+tersebut+dapat+berpotensi+sebagai+agen+kemopreventif+terhadap%0D%0Aonkogenesis+pada+paru-paru+mencit+dan+memiliki+efektivitas+sebaik+taurin+yang%0D%0Amemiliki+kemampuan+sebagai+antikanker.+Penelitian+ini+dilakukan+menggunakan%0D%0Arancangan+acak+lengkap+dengan+lima+kelompok+perlakuan%2C+masing-masing+lima%0D%0Aulangan.+Kelompok+I+sebagai+kontrol+negatif+yang+tidak+diberikan+perlakuan.%0D%0AKelompok+II+sebagai+kontrol+positif%2C+diinduksi+BaP+tanpa+diberikan+bahan+uji.%0D%0AKelompok+III+diberikan+taurin+dengan+dosis+15%2C6+mg%2Fekor+setelah+diinduksi+BaP.%0D%0AKelompok+IV+diberikan+ekstrak+metanol+daun+jeruju+dengan+dosis+22%2C4+mg%2Fekor%0D%0Asetelah+diinduksi+BaP.+Kelompok+V+diberikan+ekstrak+metanol+lamun+dengan%0D%0Adosis+8%2C7+mg%2Fekor+setelah+diinduksi+BaP.+Induksi+BaP+dengan+dosis+0%2C3+mg%2Fekor%0D%0Adilakukan+selama+10+hari%2C+kemudian+pemberian+bahan+uji+dilakukan+selama+15%0D%0Ahari.+Data+yang+diperoleh+dianalisis+dengan+ANOVA+dan+dilanjutkan+dengan+uji%0D%0ALSD+pada+taraf+nyata+5%25.+Hasil+yang+diperoleh+menunjukan+bahwa+pemberian%0D%0Abahan+uji+dapat+mempertahankan+jumlah+eritrosit+dan+leukosit+pada+kisaran%0D%0Anormal+dan+mengurangi+kerusakan+jaringan+paru-paru+mencit+secara+signifikan%0D%0Aakibat+induksi+BaP%2C+dengan+urutan+dari+yang+paling+efektif+adalah+taurin%2C+ekstrak%0D%0Adaun+jeruju%2C+dan+terakhir%2C+ekstrak+lamun.%0D%0AKata+kunci+%3A+Jeruju%2C+lamun%2C+onkogenesis%2C+paru-paru%2C+PAH&rft.publisher=FAKULTAS+MIPA&rft.date=2019&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58231%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58231%2F3%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58231%2F2%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Yonathan+Christyanto%2C+1517021151++(2019)+POTENSI+EKSTRAK+METANOL+DAUN+JERUJU+(Acanthus+ilicifolius+L.)+DAN+LAMUN+(Enhalus+acoroides)+SEBAGAI+AGEN+KEMOPREVENTIF+TERHADAP+ONKOGENESIS+PADA+PARU-PARU+MENCIT+(Mus+musculus+L.)+YANG+DIINDUKSI+SENYAWA+POLISIKLIK+AROMATIK+HIDROKARBON+(PAH).++FAKULTAS+MIPA%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F58231%2F