?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+EKSTRAK+BIJI+KOPI+ROBUSTA%0D%0A(Coffeacanephora)+LAMPUNG+TERHADAP+MEMORI+SPASIAL+TIKUS%0D%0APUTIH+JANTAN+(Rattus+norvegicus)+GALUR+Sprague+dawley%0D%0AYANG+DIINDUKSIMONOSODIUM+GLUTAMAT&rft.creator=Anis+Syafa'atul+Husna%2C+1518011063&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+Belakang%3A+Monosodium+glutamat+(MSG)+sebagaipenyedap%0D%0Arasaapabiladiberikansecaraberlebihanakanmengaktivasireseptorglutamatberlebihsehingga%0D%0Adapatmenyebabkankerusakanotak.Kopi+mengandungasamklorogenatyang%0D%0Abersifatneuroprotektif.Tujuanpenelitianiniuntukmengetahui+pengaruhpemberianekstrak%0D%0Akopi+robusta+(Coffeacanephora)+Lampung+terhadapmemorispasialtikusputihjantan%0D%0A(Rattusnorvegicus)+yang+diinduksiMSG.%0D%0AMetode%3APenelitianinidilakukandenganmetodeeksperimentaldenganrancanganacaklengkap%0D%0A.+Jumlahsampelyang+digunakansebanyak+25+ekordandibagi+5+kelompok%2C+masingmasingterdiridari+5+ekortikus.PadapenelitianinitikusdiinduksiMSGperoraldengandosis+2%0D%0Agr%2FkgBB%2Fhariuntukkelompokkontrolpositifdansecaraberurutankelompokperlakuan+1%2C+2%2C%0D%0Adan3+disertaiinduksiekstrak+kopirobusta+Lampung+dengandosis0%2C5+mg%2FmL%2Fhari%2C+1%0D%0Amg%2FmL%2Fhari%2C+dan+2+mg%2FmL%2Fhari.%0D%0ASelanjutnyapenilaianmemorispasialdilakukandenganmetodeMorris+Water+Maze(MWM).%0D%0AHasil%3AHasilreratamemorispasialsecaraberurutankelompok+K(-)%2C+K(%2B)%2C+P1%2C+P2%2C+P3%0D%0Aadalah22.75%C2%B14.50detik%2C+15.80%C2%B1+9.91detik%2C+16.80%C2%B1+5.71detik%2C+25.00%C2%B1+15.13detik%2C+25.60%C2%B1%0D%0A10.47detik.Hasil+analisis+statistikOne+Way+Anova%2C+nilai+p%3D0%2C294+sehingga+dapat%0D%0Adinyatakan+bahwa+tidak+terdapat+perbedaan+rerata+pada+semuakelompok.%0D%0ASimpulan%3A+Tidak+terdapat+pengaruh+pemberian+ekstrak+kopi+robusta+(coffeacanephora)%0D%0Alampung+terhadap+memori+spasial+tikus+putih+jantan(rattus+novergicus)%0D%0Agalurspraguedawleyyang+diinduksiMSG.%0D%0AKata+Kunci%3A+kopi+robusta%2C+memori+spasial%2C+monosodium+glutamat%0D%0A%0D%0ABackground%3AMonosodium+glutamate+(MSG)+as+a+flavor+when+given+in+excess+will%0D%0Aactivate+excess+glutamate+receptors+so+that+it+can+cause+brain+damage.+Coffee+contains%0D%0Aneuroprotectivechlorogenic+acid.+The+purpose+of+this+study+was+to+determine+the+effect+of%0D%0ALampung+Robusta+coffee+(Coffeacanephora)+extract+on+the+spatial+memory+of+MSGinduced+male+white+rats+(Rattusnorvegicus).%0D%0AMethod%3AThis+research+was+carried+out+using+an+experimental+method+with+a+completely%0D%0Arandomized+design.+The+number+of+samples+used+was+25+and+divided+into+5+groups%2C+each%0D%0Aconsisting+of+5+rats.+In+this+study+rats+were+induced+by+oral+MSG+at+a+dose+of+2+gr+%2F+kgBW%0D%0A%2F+day+for+the+positive+control+group+and+sequentially+treatment+groups+1%2C+2%2C+and+3+were%0D%0Aaccompanied+by+induction+of+Lampung+robusta+coffee+extract+at+a+dose+of+0.5+mg+%2F+mL+%2F%0D%0Aday%2C+1+mg+%2F+mL+%2F+day%2C+and+2+mg+%2F+mL+%2F+day.+Furthermore%2C+the+assessment+of+spatial%0D%0Amemory+was+carried+out+by+the+Morris+Water+Maze+(MWM)+method.%0D%0AResults%3AThe+average+results+of+spatial+memory+sequentially+groups+K+(-)%2C+K+(%2B)%2C+P1%2C+P2%2C%0D%0AP3+are+22.75+%C2%B1+4.50+second%2C+15.80+%C2%B1+9.91+second%2C+16.80+%C2%B1+5.71+second%2C+25.00+%C2%B1+15.13%0D%0Asecond%2C+25.60+%C2%B1+10.47+secondThe+results+of+One+Way+Anova+analysis+have+a+result+of%0D%0A0.294%2C+p%3E+0.05.+So+that+it+can+be+stated+that+there+is+no+difference+in+mean+in+all+group.%0D%0AConclusion%3AThere+is+no+effect+on+the+administration+of+Robusta+coffee+extract%0D%0A(Coffeacanephora)+Lampung+to+the+spatial+memory+of+male+white+rats+(rattusnovergicus)%0D%0Aspraguedawley+lines+induced+by+monosodium+glutamate.%0D%0AKeywords%3A+monosodium+glutamate%2C+robusta+coffee%2C+spatial+memory&rft.publisher=Fakultas+Kedokteran+&rft.date=2019-04-09&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58360%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58360%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58360%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Anis+Syafa'atul+Husna%2C+1518011063++(2019)+PENGARUH+PEMBERIAN+EKSTRAK+BIJI+KOPI+ROBUSTA+(Coffeacanephora)+LAMPUNG+TERHADAP+MEMORI+SPASIAL+TIKUS+PUTIH+JANTAN+(Rattus+norvegicus)+GALUR+Sprague+dawley+YANG+DIINDUKSIMONOSODIUM+GLUTAMAT.++Fakultas+Kedokteran+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F58360%2F