title: PENGARUH PEMBERIAN EKSTRAK BIJI KOPI ROBUSTA  (Coffeacanephora) LAMPUNG TERHADAP MEMORI SPASIAL TIKUS  PUTIH JANTAN (Rattus norvegicus) GALUR Sprague dawley  YANG DIINDUKSIMONOSODIUM GLUTAMAT
creator: Anis Syafa'atul Husna, 1518011063
subject: 610 Ilmu kedokteran, ilmu pengobatan dan ilmu kesehatan
description: Latar Belakang: Monosodium glutamat (MSG) sebagaipenyedap  rasaapabiladiberikansecaraberlebihanakanmengaktivasireseptorglutamatberlebihsehingga  dapatmenyebabkankerusakanotak.Kopi mengandungasamklorogenatyang  bersifatneuroprotektif.Tujuanpenelitianiniuntukmengetahui pengaruhpemberianekstrak  kopi robusta (Coffeacanephora) Lampung terhadapmemorispasialtikusputihjantan  (Rattusnorvegicus) yang diinduksiMSG.  Metode:Penelitianinidilakukandenganmetodeeksperimentaldenganrancanganacaklengkap  . Jumlahsampelyang digunakansebanyak 25 ekordandibagi 5 kelompok, masingmasingterdiridari 5 ekortikus.PadapenelitianinitikusdiinduksiMSGperoraldengandosis 2  gr/kgBB/hariuntukkelompokkontrolpositifdansecaraberurutankelompokperlakuan 1, 2,  dan3 disertaiinduksiekstrak kopirobusta Lampung dengandosis0,5 mg/mL/hari, 1  mg/mL/hari, dan 2 mg/mL/hari.  SelanjutnyapenilaianmemorispasialdilakukandenganmetodeMorris Water Maze(MWM).  Hasil:Hasilreratamemorispasialsecaraberurutankelompok K(-), K(+), P1, P2, P3  adalah22.75±4.50detik, 15.80± 9.91detik, 16.80± 5.71detik, 25.00± 15.13detik, 25.60±  10.47detik.Hasil analisis statistikOne Way Anova, nilai p=0,294 sehingga dapat  dinyatakan bahwa tidak terdapat perbedaan rerata pada semuakelompok.  Simpulan: Tidak terdapat pengaruh pemberian ekstrak kopi robusta (coffeacanephora)  lampung terhadap memori spasial tikus putih jantan(rattus novergicus)  galurspraguedawleyyang diinduksiMSG.  Kata Kunci: kopi robusta, memori spasial, monosodium glutamat    Background:Monosodium glutamate (MSG) as a flavor when given in excess will  activate excess glutamate receptors so that it can cause brain damage. Coffee contains  neuroprotectivechlorogenic acid. The purpose of this study was to determine the effect of  Lampung Robusta coffee (Coffeacanephora) extract on the spatial memory of MSGinduced male white rats (Rattusnorvegicus).  Method:This research was carried out using an experimental method with a completely  randomized design. The number of samples used was 25 and divided into 5 groups, each  consisting of 5 rats. In this study rats were induced by oral MSG at a dose of 2 gr / kgBW  / day for the positive control group and sequentially treatment groups 1, 2, and 3 were  accompanied by induction of Lampung robusta coffee extract at a dose of 0.5 mg / mL /  day, 1 mg / mL / day, and 2 mg / mL / day. Furthermore, the assessment of spatial  memory was carried out by the Morris Water Maze (MWM) method.  Results:The average results of spatial memory sequentially groups K (-), K (+), P1, P2,  P3 are 22.75 ± 4.50 second, 15.80 ± 9.91 second, 16.80 ± 5.71 second, 25.00 ± 15.13  second, 25.60 ± 10.47 secondThe results of One Way Anova analysis have a result of  0.294, p> 0.05. So that it can be stated that there is no difference in mean in all group.  Conclusion:There is no effect on the administration of Robusta coffee extract  (Coffeacanephora) Lampung to the spatial memory of male white rats (rattusnovergicus)  spraguedawley lines induced by monosodium glutamate.  Keywords: monosodium glutamate, robusta coffee, spatial memory
publisher: Fakultas Kedokteran 
date: 2019-04-09
type: Skripsi
type: NonPeerReviewed
format: text
identifier: http://digilib.unila.ac.id/58360/1/ABSTRAK.pdf
format: text
identifier: http://digilib.unila.ac.id/58360/2/SKRIPSI%20FULL.pdf
format: text
identifier: http://digilib.unila.ac.id/58360/3/SKRIPSI%20TANPA%20BAB%20PEMBAHASAN.pdf
identifier:   Anis Syafa'atul Husna, 1518011063  (2019) PENGARUH PEMBERIAN EKSTRAK BIJI KOPI ROBUSTA (Coffeacanephora) LAMPUNG TERHADAP MEMORI SPASIAL TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR Sprague dawley YANG DIINDUKSIMONOSODIUM GLUTAMAT.  Fakultas Kedokteran , UNIVERSITAS LAMPUNG.     
relation: http://digilib.unila.ac.id/58360/