?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+EKSTRAK+ETANOL+KULIT+BATANG+BAKAU%0D%0AMINYAK+(Rhizophora+apiculata)+TERHADAP+HISTOPATOLOGI+GINJAL%0D%0A%0D%0ATIKUS+PUTIH+JANTAN+(Rattus+norvergicus)+GALUR+SPRAGUE-%0D%0ADAWLEY+YANG+DIPAPARKAN+ASAP+ROKOK&rft.creator=Sarasmita+Nirmala+Dewi%2C+1518011024&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Background.+Rhizophora+apiculata+bark+contains+high+antioxidants+including%0D%0Atriterpenoids%2C+steroids%2C+saponins+and+tannins.+High+antioxidant+can+prevent+oxidative%0D%0Astress%2C+one+of+which+is+caused+by+free+radicals+from+cigarette+smoke.+The+purpose+of%0D%0Athis+study+was+to+determine+the+potential+of+Rhizophora+apiculata+in+protecting%0D%0Akidney+damage+from+exposed+to+cigarette+smoke+of+male+white+rats+(Rattus%0D%0Anovergicus)+Spargue-Dawley+strain.%0D%0AMethods.+This+study+used+25+rats+divided+into+10+groups+for+30+days%2C+namely+group%0D%0AK+(-)+which+was+not+exposed+to+cigarette+smoke+and+extracts+of+mangrove+bark%2C+group%0D%0AK+(%2B)+which+was+only+given+exposure+to+cigarette+smoke%2C+group+P1+given+extract%0D%0Amangrove+bark+with+a+dose+of+28.27+mg%2FkgBB+and+given+exposure+to+cigarette+smoke%0D%0A24+cigarettes+per+day%2C+P2+group+given+the+extract+of+mangrove+bark+with+a+dose+of%0D%0A56.55+mg%2FkgBB+and+given+exposure+to+cigarette+smoke+24+cigarettes+per+day%2C+and+the%0D%0AP3+group+given+mangrove+bark+extract+with+a+dose+of+113.1+mg%2FkgBB+and+given%0D%0Acigarette+smoke+exposure+24+cigarettes+per+day.+Kidney+histopathology+was+assessed%0D%0Ausing+a+microscope+with+a+400x+magnification+in+5+fields.+Data+were+analyzed+using%0D%0Athe+Kruskall-Wallis+test.%0D%0AResults.+The+mean+score+of+kidney+damage+in+group+K+(-)+was+0.4%2C+group+K+(%2B)+was%0D%0A3.6%2C+group+P1+was+2.4%2C+group+P2+was+2.4+and+group+P3+was+2.2.+The+Kruskal-Wallis%0D%0Atest+results+obtained+a+p+value+of+0.001%2C+which+means+that+there+were+significant%0D%0Adifferences+in+at+least+2+treatment+groups.%0D%0AConclusion.+There+is+an+effect+of+the+administration+of+mangrove+bark+extract%0D%0A(Rhizophora+apiculata)+on+the+histopathology+of+kidney+male+white+rats+exposed+to%0D%0Acigarette+smoke%2C+with+a+statistically+effective+dose+is+the+dose+of+28.27+mg%2Fml.%0D%0A%0D%0AKeyword%3A+cigarette%2C+histopathology%2C+kidney%2C+Rhizophora+apiculata%2C+Spargue-%0D%0ADawley.%0D%0A%0D%0ALatar+belakang.+Kulit+batang+bakau+minyak+(Rhizophora+apiculata)+mengandung%0D%0Aantioksidan+yang+tinggi+diantaranya+triterpenoid%2C+steroid%2C+saponin+dan+tanin.%0D%0AKandungan+antioksidan+yang+tinggi+dapat+mencegah+terjadinya+stress+oksidatif%2C+salah%0D%0Asatunya+disebabkan+oleh+radikal+bebas+dari+asap+rokok.+Tujuan+penelitian+ini%0D%0Amengetahui+potensi+kulit+batang+bakau+minyak+(Rhizophora+apiculata)+dalam%0D%0Amelindungi+kerusakan+organ+ginjal+tikus+putih+jantan+(Rattus+novergicus)+galur%0D%0ASpargue-Dawley+yang+terpapar+asap+rokok.%0D%0AMetode+penelitian.+Penelitian+ini+menggunakan+25+ekor+tikus+yang+terbagi+dalam+10%0D%0Akelompok+selama+30+hari%2C+yaitu+kelompok+K(-)+yang+tidak+diberikan+paparan+asap%0D%0Arokok+dan+ekstrak+kulit+batang+bakau%2C+kelompok+K(%2B)+yang+hanya+diberikan+paparan%0D%0Aasap+rokok%2C+kelompok+P1+yang+diberikan+ekstrak+kulit+batang+bakau+minyak+dengan%0D%0Adosis+28%2C27+mg%2FkgBB+serta+diberikan+paparan+asap+rokok+24+batang+perhari%2C%0D%0Akelompok+P2+yang+diberikan+ekstrak+kulit+batang+bakau+minyak+dengan+dosis+56%2C55%0D%0Amg%2FkgBB+serta+diberikan+paparan+asap+rokok+24+batang+perhari%2C+dan+kelompok+P3%0D%0Ayang+diberikan+ekstrak+kulit+batang+bakau+minyak+dengan+dosis+113%2C1+mg%2FkgBB+serta%0D%0Adiberikan+paparan+asap+rokok+24+batang+perhari.+Histopatologi+ginjal+dinilai%0D%0Amenggunakan+mikroskop+dengan+perbesaran+400x+dalam+5+lapang+padang.+Data%0D%0Adianalisis+menggunakan+uji+Kruskall-Wallis.%0D%0AHasil+penelitian.+Median+skor+kerusakan+ginjal+pada+kelompok+K(-)+ialah+0%2C4%2C%0D%0Akelompok+K(%2B)+sebesar+3%2C6%2C+kelompok+P1+sebesar+2%2C4%2C+kelompok+P2+sebesar+2%2C4+dan%0D%0Akelompok+P3+sebesar+2%2C2.+Hasil+uji+Kruskal-Wallis+di+dapatkan+nilai+p+sebesar+0%2C001%2C%0D%0Ayang+berarti+bahwa+terdapat+perbedaan+yang+bermakna+setidaknya+pada+2+kelompok%0D%0Aperlakuan.%0D%0ASimpulan.+Terdapat+pengaruh+dari+pemberian+ekstrak+kulit+batang+bakau%0D%0A(Rhizophora+apiculata)+terhadap+histopatologi+ginjal+tikus+putih+jantan+yang+terpapar%0D%0Aasap+rokok%2C+dengan+secara+statistik+dosis+yang+efektif+ialah+dosis+28%2C27+mg%2Fml%0D%0AKata+kunci%3A+Ginjal%2C+Histopatologi%2C+Rhizophora+apiculata%2C+Rokok%2C+Spargue-Dawley.&rft.publisher=Fakultas+Kedokteran&rft.date=2019-01-18&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58510%2F2%2FABSTRAK%2520-%2520Sarasmita%2520Nirmala%2520Dewi.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58510%2F1%2FSKRIPSI%2520FULL%2520-%2520Sarasmita%2520Nirmala%2520Dewi.pdf&rft.format=text&rft.iden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