?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+EKSTRAK+ETANOL+BELIMBING+WULUH%0D%0A(Averrhoa+bilimbi+Linn.)+SEBAGAI+ANTIOKSIDAN+TERHADAP+KADAR%0D%0ASGPT+(Serum+Glutamic+Pyruvate+Transaminase)+SERTA%0D%0ASGOT+(Serum+Glutamic+Oxaloacetic+Transaminase)%0D%0ATIKUS+GALUR+Sprague+dawley+YANG+DIINDUKSI+PARASETAMOL&rft.creator=Danang+Hafizfadillah%2C+1518011144&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+Belakang.+Parasetamol+merupakan+obat+antipiretik+yang+bila+digunakan%0D%0Adengan+dosis+lebih+dari+4+g%2Fhari+dapat+menyebabkan+hepatotoksisitas.+SGPT%0D%0A(Serum+Glutamic+Pyruvate+Transaminase)+dan+SGOT+(Serum+Glutamic%0D%0AOxaloacetic+Transaminase)+adalah+enzim+hepar+pada+darah+yang+dapat+dijadikan%0D%0Aacuan+kerusakan+sel-sel+hepar.+Buah+belimbing+wuluh+(Averrhoa+Bilimbi+L.)%0D%0Amemiliki+senyawa+antioksidan+yang+bersifat+hepatoprotektif+terhadap+kerusakan%0D%0Asel+hepar.+Penelitian+ini+bertujuan+untuk+mengetahui+pengaruh+pemberian+ekstrak%0D%0Aetanol+belimbing+wuluh+terhadap+kadar+SGPT+serta+SGOT+darah+tikus+yang%0D%0Adiinduksi+parasetamol%2C+serta+pengaruh+peningkatan+dosis+ekstrak+etanol+belimbing%0D%0Awuluh+terhadap+kadar+SGOT+dan+SGPT+darah+tikus+yang+diinduksi+parasetamol.%0D%0AMetode+Penelitian.+Jenis+penelitian+ini+adalah+eksperimental+laboratorik+dengan%0D%0Adesain+posttest+only+control+group+design%2C+menggunakan+30+ekor+tikus+galur%0D%0ASprague+dawley+yang+terbagi+menjadi+5+kelompok%2C+2+kelompok+kontrol+dan+3%0D%0Akelompok+perlakuan%2C+kelompok+tersebut+diberi+perlakuan+selama+14+hari%0D%0Apemberian+ekstrak+belimbing+wuluh+berbeda+dosis%2C+dan+7+hari+pemberian%0D%0Aparasetamol+dosis+toksik+1%2C8gr+dimulai+dari+hari+ke-8.%0D%0AHasil+penelitian.+Ekstrak+belimbing+wuluh+dosis+0%2C8+g%2FkgBB+dan+1%2C6+g%2FkgBB%0D%0Adapat+menurunkan+kadar+SGOT+dengan+rerata+skor+271%2C2+dan+206%2C2.+Ekstrak%0D%0Abelimbing+wuluh+dengan+dosis+1%2C6g%2FkgBB+juga+dapat+menurunkan+kadar+SGPT%0D%0Adengan+rerata+skor+62%2C8.%0D%0ASimpulan.+Terdapat+pengaruh+pemberian+ekstrak+etanol+belimbing+wuluh%0D%0Aterhadap+kadar+SGOT+dan+SGPT+darah+tikus+yang+diinduksi+parasetamol%2C+dan%0D%0Aterdapat+pengaruh+perbedaan+dosis+dari+ekstrak+belimbing+wuluh+hanya+kepada%0D%0Akadar+SGOT+dan+tidak+pada+kadar+SGPT+tikus+yang+diinduksi+parasetamol.%0D%0AKata+Kunci%3A+Belimbing+Wuluh%2C+parasetamol%2C+SGOT%2C+SGPT.%0D%0A%0D%0ABackground.+Paracetamol+is+an+antipyretic+drug+and+with+a+dose+of+more+than+4%0D%0Agrams+per+day+can+cause+hepatotoxicity.+SGPT+(Serum+Glutamic+Pyruvate%0D%0ATransaminase)+and+SGOT+(Serum+Glutamic+Oxyloacetic+Transaminase)+is+an%0D%0Aenzyme+of+liver+that+can+be+reffered+to+the+damaged+of+the+liver+cells.+Averrhoa%0D%0ABilimbi+L+has+antioxidant+compounds+that+act+as+hepatoprotector+from+liver+cell%0D%0Adamage.+The+purpose+of+this+research+is+to+determine+the+effect+of+ethanol+extract%0D%0Aof+Averrhoa+Bilimbi+L+application+as+an+antioxidant+on+the+levels+of+SGPT+and%0D%0ASGOT+of+blood+in+rats+induced+by+paracetamol%2C+and+to+determine+the+effect+of%0D%0Aincreasing+dose+of+Averrhoa+Bilimbi+L+ethanol+extract+to+the+levels+of+SGPT+and%0D%0ASGOT+of+blood+in+rats+induced+by+parasetamol.%0D%0AMethods.+This+study+was+a+laboratory+experimental+study+with+a+posttest+only%0D%0Acontrol+group+design+using+30+Sprague+dawley+white+rats+divided+into+5+groups%2C+2%0D%0Acontrol+groups+and+3+treatment+groups%2C+and+treated+for+14+days+giving+Averrhoa%0D%0ABilimbi+L+extract+in+different+dose%2C+and+7+days+of+toxic+dose+of+1.8+gr+paracetamol%0D%0Aadministration+starting+from+the+8th+day.%0D%0AResults.+The+extracts+of+Averrhoa+Bilimbi+L+doses+of+0.8+g%2FkgBB+and+1.6+g%2FkgBB%0D%0Acould+reduce+SGOT+levels+with+a+mean+score+of+271.2+and+206.2.+The+Averrhoa%0D%0ABilimbi+L+extract+at+a+dose+of+1.6+g%2FkgBB+can+also+reduce+SGPT+levels+with+a%0D%0Amean+score+of+62.8.%0D%0AConclusion.+There+was+an+effect+of+giving+ethanol+extract+of+Averrhoa+Bilimbi+L%0D%0Ato+SGOT+and+SGPT+levels+of+blood+of+Sprague+dawley+rats+which+were+induced%0D%0Aby+paracetamol%2C+and+there+was+an+effect+of+different+dose+of+ethanol+extract+of%0D%0AAverrhoa+Bilimbi+L+application+to+just+the+SGOT+levels%2C+not+the+SGPT+levels+of%0D%0Ablood+of+Sprague+dawley+induced+by+parasetamol.%0D%0AKeywords%3A+Averrhoa+Bilimbi+L%2C+paracetamol%2C+SGOT%2C+SGPT&rft.publisher=Fakultas+Kedokteran+&rft.date=2019-01-24&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58829%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58829%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58829%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Danang+Hafizfadillah%2C+1518011144++(2019)+PENGARUH+EKSTRAK+ETANOL+BELIMBING+WULUH+(Averrhoa+bilimbi+Linn.)+SEBAGAI+ANTIOKSIDAN+TERHADAP+KADAR+SGPT+(Serum+Glutamic+Pyruvate+Transaminase)+SERTA+SGOT+(Serum+Glutamic+Oxaloacetic+Transaminase)+TIKUS+GALUR+Sprague+dawley+YANG+DIINDUKSI+PARASETAMOL.++Fakultas+Kedokteran+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F58829%2F