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<http://digilib.unila.ac.id/id/eprint/58829> <http://purl.org/dc/terms/title> "PENGARUH EKSTRAK ETANOL BELIMBING WULUH\r\n(Averrhoa bilimbi Linn.) SEBAGAI ANTIOKSIDAN TERHADAP KADAR\r\nSGPT (Serum Glutamic Pyruvate Transaminase) SERTA\r\nSGOT (Serum Glutamic Oxaloacetic Transaminase)\r\nTIKUS GALUR Sprague dawley YANG DIINDUKSI PARASETAMOL"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://digilib.unila.ac.id/id/eprint/58829> <http://purl.org/ontology/bibo/abstract> "Latar Belakang. Parasetamol merupakan obat antipiretik yang bila digunakan\r\ndengan dosis lebih dari 4 g/hari dapat menyebabkan hepatotoksisitas. SGPT\r\n(Serum Glutamic Pyruvate Transaminase) dan SGOT (Serum Glutamic\r\nOxaloacetic Transaminase) adalah enzim hepar pada darah yang dapat dijadikan\r\nacuan kerusakan sel-sel hepar. Buah belimbing wuluh (Averrhoa Bilimbi L.)\r\nmemiliki senyawa antioksidan yang bersifat hepatoprotektif terhadap kerusakan\r\nsel hepar. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak\r\netanol belimbing wuluh terhadap kadar SGPT serta SGOT darah tikus yang\r\ndiinduksi parasetamol, serta pengaruh peningkatan dosis ekstrak etanol belimbing\r\nwuluh terhadap kadar SGOT dan SGPT darah tikus yang diinduksi parasetamol.\r\nMetode Penelitian. Jenis penelitian ini adalah eksperimental laboratorik dengan\r\ndesain posttest only control group design, menggunakan 30 ekor tikus galur\r\nSprague dawley yang terbagi menjadi 5 kelompok, 2 kelompok kontrol dan 3\r\nkelompok perlakuan, kelompok tersebut diberi perlakuan selama 14 hari\r\npemberian ekstrak belimbing wuluh berbeda dosis, dan 7 hari pemberian\r\nparasetamol dosis toksik 1,8gr dimulai dari hari ke-8.\r\nHasil penelitian. Ekstrak belimbing wuluh dosis 0,8 g/kgBB dan 1,6 g/kgBB\r\ndapat menurunkan kadar SGOT dengan rerata skor 271,2 dan 206,2. Ekstrak\r\nbelimbing wuluh dengan dosis 1,6g/kgBB juga dapat menurunkan kadar SGPT\r\ndengan rerata skor 62,8.\r\nSimpulan. Terdapat pengaruh pemberian ekstrak etanol belimbing wuluh\r\nterhadap kadar SGOT dan SGPT darah tikus yang diinduksi parasetamol, dan\r\nterdapat pengaruh perbedaan dosis dari ekstrak belimbing wuluh hanya kepada\r\nkadar SGOT dan tidak pada kadar SGPT tikus yang diinduksi parasetamol.\r\nKata Kunci: Belimbing Wuluh, parasetamol, SGOT, SGPT.\r\n\r\nBackground. Paracetamol is an antipyretic drug and with a dose of more than 4\r\ngrams per day can cause hepatotoxicity. SGPT (Serum Glutamic Pyruvate\r\nTransaminase) and SGOT (Serum Glutamic Oxyloacetic Transaminase) is an\r\nenzyme of liver that can be reffered to the damaged of the liver cells. Averrhoa\r\nBilimbi L has antioxidant compounds that act as hepatoprotector from liver cell\r\ndamage. The purpose of this research is to determine the effect of ethanol extract\r\nof Averrhoa Bilimbi L application as an antioxidant on the levels of SGPT and\r\nSGOT of blood in rats induced by paracetamol, and to determine the effect of\r\nincreasing dose of Averrhoa Bilimbi L ethanol extract to the levels of SGPT and\r\nSGOT of blood in rats induced by parasetamol.\r\nMethods. This study was a laboratory experimental study with a posttest only\r\ncontrol group design using 30 Sprague dawley white rats divided into 5 groups, 2\r\ncontrol groups and 3 treatment groups, and treated for 14 days giving Averrhoa\r\nBilimbi L extract in different dose, and 7 days of toxic dose of 1.8 gr paracetamol\r\nadministration starting from the 8th day.\r\nResults. The extracts of Averrhoa Bilimbi L doses of 0.8 g/kgBB and 1.6 g/kgBB\r\ncould reduce SGOT levels with a mean score of 271.2 and 206.2. The Averrhoa\r\nBilimbi L extract at a dose of 1.6 g/kgBB can also reduce SGPT levels with a\r\nmean score of 62.8.\r\nConclusion. There was an effect of giving ethanol extract of Averrhoa Bilimbi L\r\nto SGOT and SGPT levels of blood of Sprague dawley rats which were induced\r\nby paracetamol, and there was an effect of different dose of ethanol extract of\r\nAverrhoa Bilimbi L application to just the SGOT levels, not the SGPT levels of\r\nblood of Sprague dawley induced by parasetamol.\r\nKeywords: Averrhoa Bilimbi L, paracetamol, SGOT, SGPT"^^<http://www.w3.org/2001/XMLSchema#string> .
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