?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+MINYAK+BUAH+MERAH%0D%0A(Pandanus+conoideus)+TERHADAP+AKTIVITAS+ALT%0D%0ADAN+AST+PADA+MENCIT+YANG+DIINFEKSI%0D%0APlasmodium+berghei&rft.creator=Dianti+Sevina+Elmasari%2C+1518011048&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+Belakang%3A+Malaria+masih+menjadi+permasalahan+kesehatan+baik+di%0D%0AIndonesia+maupun+dunia.+Siklus+hidup+plasmodium+yang+melibatkan+hepar%0D%0Amemicu+keterlibatan+fagosit+seperti+neutrofil+dan+makrofag+hingga+menyebabkan%0D%0Apeningkatan+ROS+dan+RNS.+Apabila+hal+ini+berlebih+akan+mengakibatkan%0D%0Aketidakseimbangan+antara+aktivitas+pengoksidasi+dan+antioksidan+di+dalam+tubuh%0D%0Adan+memicu+radikal+bebas.+Minyak+buah+merah+memiliki+kandungan+betakaroten%0D%0Ayang+mampu+mencegah+pembentukan+radikal+bebas+hingga+diharapkan+mampu%0D%0Amengurangi+kerusakan+hepar.%0D%0AMetode%3A+Penelitian+ini+menggunakan+Post+Test+Only+Control+Group+Design+dan%0D%0Ametode+4+days+supressive+test.+Sampel+mencit+sebanyak+32+ekor.+Tekhnik+yang%0D%0Adigunakan+pada+pengambilan+sampel+yakni+simple+random+sampling+dengan%0D%0Asubjek+yang+telah+memenuhi+kriteria+inklusi+dan+eksklusi.%0D%0AHasil+%3A+Ditemukan+adanya+peningkatan+aktivitas+ALT+dan+AST+pada+setiap%0D%0Akelompok+perlakuan.+Hasil+uji+One-Way+ANOVA+aktivitas+rerata+ALT%0D%0Amenghasilkan+p+value+0%2C074+dan+aktivitas+rerata+AST+menghasilkan+p+value+0%2C006.%0D%0AKesimpulan%3A+Ditemukan+adanya+peningkatan+aktivitas+ALT+dan+AST%2C+terdapat%0D%0Aperbedaan+rerata+aktivitas+AST%2C+namun+tidak+terdapat+perbedaan+rerata+aktivitas%0D%0AALT+pada+setiap+kelompok+perlakuan+mencit+yang+diinfeksi+Plasmodium+berghei%0D%0Adan+diberikan+kombinasi+klorokuin+serta+minyak+buah+merah.%0D%0AKata+kunci+%3A+ALT%2C+AST%2C+Minyak+Buah+Merah%0D%0A%0D%0ABackground%3A+Malaria+still+becomes+health+problem+in+the+world+and+Indonesia.%0D%0AThe+plasmodium%E2%80%99s+life+cycle+that+involve+the+liver+trigger+involvement+of%0D%0Aphagocytes+such+neutrophils+and+macrophages+will+cause+an+increase+of+ROS+and%0D%0ARNS.+If+they+were+excessive%2C+it+causes+imbalance+between+oxidizing+and%0D%0Aantioxidant+activities+in+the+body+which+ultimately+triggers+the+formation+of+free%0D%0Aradicals.+Red+fruit+oil+contain+beta-carotene+that+can+prevent+the+formation+of+free%0D%0Aradicals+and+expected+to+reduce+liver+damage.%0D%0AMethod%3A+This+study+used+Post+Test+Only+Control+Group+Design+and+using+4+days%0D%0Asupressive+test+The+sample+of+this+study+used+32+and+simple+random+sampling%0D%0Atechnique+that+matched+the+inclusion+and+exclusion+criteria..%0D%0AResults%3A+There+was+an+increase+on+ALT+and+AST+activity+in+each+treatment+group.%0D%0AThe+result+of+One-Way+ANOVA+test+were+0.074+(ALT%E2%80%99s+p+value+)+and+0.006%0D%0A(AST%E2%80%99s+p+value).%0D%0AConclusion%3A+There+was+an+increase+on+ALT+and+AST+%2C+There+was+mean+difference%0D%0Aon+AST%2C+%2C+but+there+was+no+mean+difference+on+ALT+activity.+in+each+treatment%0D%0Agroup+of+mice+infected+by+Plasmodium+berghei+and+given+a+combination+of%0D%0Achloroquine+and+red+fruit+oil.%0D%0AKeywords%3A+ALT%2C+AST%2C+Red+Fruit+Oil&rft.publisher=Fakultas+Kedokteran+&rft.date=2019-01-14&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58868%2F1%2FABSTRAK%2520%2528ABSTRACT%2529.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58868%2F2%2FSKIRPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58868%2F3%2FSKRIPSI%2520TANPA%2520PEMBAHASAN.pdf&rft.identifier=++Dianti+Sevina+Elmasari%2C+1518011048++(2019)+PENGARUH+PEMBERIAN+MINYAK+BUAH+MERAH+(Pandanus+conoideus)+TERHADAP+AKTIVITAS+ALT+DAN+AST+PADA+MENCIT+YANG+DIINFEKSI+Plasmodium+berghei.++Fakultas+Kedokteran+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F58868%2F