?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+MINUMAN+RINGAN+BERKABONASI%0D%0ATERHADAP+GAMBARAN+HISTOPATOLOGI+ESOFAGUS%0D%0ATIKUS+PUTIH+(Rattus+norvegicus)+JANTAN%0D%0AGALUR+Sprague+dawley&rft.creator=Fadila+Rahayu%2C+1518011034&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+Belakang%3A+Minuman+ringan+berkabonasi+atau+minuman+berkarbonasi%0D%0Amerupakan+minuman+yang+tampak+bergelembung+akibat+dari+injeksi+gas%0D%0Akarbondioksida+ke+dalam+minuman+tersebut.+Iritasi+secara+langsung+dari+keasaman%0D%0Adan+kandungan+gas+karbondioksida+yang+terdapat+dalam+minuman+ringan%0D%0Aberkabonasi+dapat+mengakibatkan+perubahan+epitel+pada+tikus+karena+epitel+pada%0D%0Aesofagus+bersifat+alkali+dan+tidak+tahan+asam.%0D%0ATujuan%3A+Untuk+mengetahui+pengaruh+pemberian+minuman+ringan+berkabonasi%0D%0Aterhadap+gambaran+histopatologi+esofagus+tikus+putih+(Rattus+norvegicus)+jantan%0D%0Agalur+Sprague+dawley.+Penelitian+ini+merupakan+penelitian+eksperimental+dengan%0D%0Adesain+post+test+only+control+group+menggunakan+24+ekor+tikus+dibagi+4+kelompok%0D%0Asecara+acak+diberi+perlakuan+selama+30+hari.+Kelompok+K+(Kontrol)%2C+P1+(diberi+3%0D%0Aml%2Fhari)%2C+P2+(diberi+6+ml%2Fhari)+dan+P3(diberi+12+ml%2Fhari).+Pada+akhir+penelitian%0D%0Atikus+dilakukan+terminasi+dan+diambil+esofagusnya+untuk+pembuatan+preparat%0D%0Ahistologi+dengan+pewarnaan+hematoksilin+eosin.%0D%0AHasil%3A+Hasil+rerata+kerusakan+histopatologi+esofagus+pada+kelompok+K%3A+0.1%2C+P1%3A%0D%0A0.67%2C+P2%3A+0.83+dan+P3%3A+1.03.+Dengan+hasil+p+pada+analisis+Kruskal-Wallis+adalah%0D%0A0%2C001+(p%3C0%2C05).+Pada+penelitian+menunjukkan+perbedaan+bermakna+(p%3C0%2C05)+pada%0D%0Akelompok+K-P1+(p%3D0%2C003)%2C+K-P2+(p%3D0%2C003)%2C+K-P3+(p%3D0%2C003)%2C+P1-P3+(p%3D0%2C007)%0D%0Adan+P2-P3+(p%3D0%2C051).%0D%0ASimpulan%3A+Terdapat+pengaruh+pemberian+minuman+ringan+berkabonasi+terhadap%0D%0Agambaran+histopatologi+esofagus+tikus+putih+(Rattus+norvegicus)+jantan+galur%0D%0ASparague+dawley.%0D%0AKata+kunci+%3A+minuman+ringan+berkabonasi%2C+esofagus%2C+histopatologi%2C+tikus+putih.%0D%0A%0D%0ABackground%3A+A+carbonated+soft+drink+is+a+drink+that+appears+bubbling+as+a+result%0D%0Aof+injection+of+carbon+dioxide+into+the+drink.+Direct+irritation+of+acidity+and+carbon%0D%0Adioxide+gas+content+in+a+carbonated+soft+drink+can+cause+epithelial+changes+in+rats%0D%0Abecause+the+epithelium+in+the+esophagus+is+alkaline+and+does+not+resist+acid.%0D%0AObjective%3A+The+aim+this+research+is+to+determine+the+effect+of+carbonated+soft%0D%0Adrinks+consumption+on+esophagus+histopathology+changes+of+male+Sprague%0D%0Adawley+white+rats+(Rattus+norvegicus).%0D%0AMethods%3A+This+research+is+an+experimental+research+with+post+test+only+control%0D%0Agroup+design+using+24+rats+were+divided+randomly+into+4+groups+and+treated+for+30%0D%0Adays.+K+as+control+group%2C+P1+(given+3+ml%2Fday)%2C+P2+(given+6+ml%2Fday)+and+P3+(given%0D%0A12+ml%2Fday).+At+the+end+of+the+study+rats+were+terminated+and+their+esophagus+was%0D%0Ataken+for+histological+preparations+with+hematoxylin+eosin+straining.%0D%0AResult%3A+The+mean+results+of+esophageal+histopathology+damage+in+group+K%3A+0.1%2C%0D%0AP1%3A+0.67%2C+P2%3A+0.83+and+P3%3A+1.03.+p+result+in+Kruskal-Wallis+test+is+0%2C001+(p%3C0.05).%0D%0AThe+results+showed+significant+differences+(p%3C0.05)+in+groups+K-P1+(p%3D0%2C003)%2C+KP2+(p%3D0%2C003)%2C+K-P3+(p%3D0%2C003)%2C+P1-P3+(p%3D0%2C007)+and+P2-P3+(p%3D0%2C051).%0D%0AConclusion%3A+There+is+an+effect+of+carbonated+soft+drinks+consumption+on%0D%0Aesophagus+histopathology+changes+of+male+Sprague+dawley+white+rats+(Rattus%0D%0Anorvegicus)%0D%0AKeywords%3A+Carbonated+soft+drinks%2C+esophagus%2C+histopatholgy%2C+white+rats&rft.publisher=Fakultas+Kedokteran+&rft.date=2019-01-15&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58894%2F1%2FABSTRAK-ABSTRACT.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58894%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58894%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Fadila+Rahayu%2C+1518011034++(2019)+PENGARUH+PEMBERIAN+MINUMAN+RINGAN+BERKABONASI+TERHADAP+GAMBARAN+HISTOPATOLOGI+ESOFAGUS+TIKUS+PUTIH+(Rattus+norvegicus)+JANTAN+GALUR+Sprague+dawley.++Fakultas+Kedokteran+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F58894%2F