?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+EKSTRAK+ETANOL+96%25+KULIT+BATANG%0D%0ABAKAU+MINYAK+(Rhizophora+apiculata)+TERHADAP+GAMBARAN%0D%0AHISTOPATOLOGI+TESTIS+PADA+TIKUS+PUTIH+JANTAN+(Rattus%0D%0Anorvegicus)+GALUR+Sprague+dawley+YANG+DIPAPARKAN+ASAP+ROKOK&rft.creator=Fauziah+Hanif%2C+1518011061&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+belakang+%3A+World+Health+Organization+(WHO)+menyebutkan+bahwa+Indonesia%0D%0Amerupakan+peringkat+pertama+diantara+Negara+ASEAN+dengan+jumlah+persentase%0D%0Aperokok+sebesar+46%2C16%25.+Paparan+terhadap+asap+rokok+dapat+menimbulkan%0D%0Apeningkatan+berbagai+masalah+kesehatan.+Laki-laki+yang+merokok+juga+lebih%0D%0Aberesiko+mengalami+kasus+infertilitas+sampai+dengan+50%25.+Aktivitas+antioksidan+dari%0D%0Aekstrak+kulit+batang+bakau+minyak+(Rhizophora+apiculata)+diketahui+memiliki%0D%0Akemampuan+dalam+menghambat+pembentukan+radikal+bebas.%0D%0AMetode+%3A+Desain+penelitian+dengan+menggunakan+metode+acak+terkontrol+dengan%0D%0Apola+post-test+control+group+design.+Sampel+terdiri+dari+25+ekor+tikus+jantan+yang%0D%0Adibagi+dalam+5+kelompok%2C+yaitu+K(-)+tidak+diberikan+perlakuan%2C+K(%2B)+yang%0D%0Adipaparkan+asap+rokok+tanpa+pemberian+ekstrak+kulit+batang+bakau+minyak%2C+kelompok%0D%0AP1+yang+dipaparkan+asap+rokok+dan+ekstrak+kulit+batang+bakau+minyak+dosis+28%2C275%0D%0Amg%2FKgBB%2C+kelompok+P2+dosis+ekstrak+56%2C55+mg%2FkgBB%2C+dan+kelompok+P3+dosis%0D%0Aekstrak+113%2C10+mg%2FkgBB.%0D%0AHasil+%3A+Analisis+menggunakan+One+Way+ANOVA+menunjukkan+terdapat+pengaruh%0D%0Apemberian+ekstrak+terhadap+rerata+jumlah+spermatosit+primer%2C+tetapi+tidak%0D%0Aberpengaruh+pada+ketebalan+tubulus+seminiferus.+Dosis+efektif+pemberian+ekstrak%0D%0Asebesar+113%2C10+mg%2FkgBB+dapat+mencegah+penurunan+jumlah+sel+spermatosit+primer%0D%0Atikus+yang+dipaparkan+asap+rokok.%0D%0AKesimpulan+%3A+Pemberian+esktrak+kulit+batang+bakau+minyak+terbukti+memiliki+efek%0D%0Aprotektif+yang+dapat+mencegah+penurunan+jumlah+sel+spermatosit+primer+tikus+putih%0D%0Ajantan+yang+dipaparkan+asap+rokok.%0D%0AKata+Kunci%3A+antioksidan%2C+rokok%2C+radikal+bebas%2C+Rhizophora+apiculata%2C+testis.%0D%0A%0D%0ABackground+%3A+The+World+Health+Organization+(WHO)+states+that+Indonesia+is+the%0D%0Afirst+rank+among+ASEAN+countries+with+a+percentage+of+smokers+of+46.16%25.%0D%0AExposure+to+cigarette+smoke+can+cause+an+increase+in+various+health+problems.+Men%0D%0Awho+smoke+are+also+more+at+risk+of+experiencing+cases+of+infertility+by+up+to+50%25.%0D%0AThe+antioxidant+activity+of+mangrove+bark+oil+extract+(Rhizophora+apiculata)+is%0D%0Aknown+to+have+the+ability+to+inhibit+the+formation+of+free+radicals.%0D%0AMethods+%3A+The+study+design+used+a+randomized+controlled+method+with+a+post-test%0D%0Acontrol+group+design+pattern.+The+sample+consisted+of+25+male+rats+divided+into+5%0D%0Agroups%2C+namely+K+(-)+not+given+treatment%2C+K+(%2B)+which+was+exposed+to+cigarette%0D%0Asmoke+without+the+administration+of+mangrove+bark+oil+extract%2C+group+P1+which+was%0D%0Aexposed+to+cigarette+smoke+and+extracts+of+oil+mangrove+bark+dosage+28%2C275+mg%2F%0D%0AkgBB%2C+P2+extract+dose+group+56%2C55+mg%2FkgBB%2C+and+P3+group+extract+dose+113%2C10+mg%0D%0A%2FkgBB.%0D%0AResults+%3A+Analysis+using+One+Way+ANOVA+showed+that+there+was+an+effect+of%0D%0Agiving+extracts+to+the+average+number+of+primary+spermatocytes%2C+but+no+effect+on+the%0D%0Athickness+of+the+seminiferous+tubules.+The+effective+dose+of+administration+of%0D%0Amangrove+bark+extract+of+113.10+mg%2FkgBB+can+prevent+a+decrease+in+the+number+of%0D%0Aprimary+spermatocyte+cells+of+rat+exposed+to+cigarette+smoke.%0D%0AConclusion+%3A+Provision+of+mangrove+bark+oil+extract+has+proven+to+have+a+protective%0D%0Aeffect+that+can+prevent+a+decrease+in+the+number+of+primary+spermatocyte+cells+of%0D%0Amale+white+rats+exposed+to+cigarette+smoke.%0D%0AKeywords%3A+antioxidants%2C+cigarette%2C+free+radicals%2C+Rhizophora+apiculata%2C+testes.+&rft.publisher=Fakultas+Kedokteran+&rft.date=2019-01-23&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58903%2F1%2FABSTRAK-ABSTRACT.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58903%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58903%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Fauziah+Hanif%2C+1518011061++(2019)+PENGARUH+PEMBERIAN+EKSTRAK+ETANOL+96%25+KULIT+BATANG+BAKAU+MINYAK+(Rhizophora+apiculata)+TERHADAP+GAMBARAN+HISTOPATOLOGI+TESTIS+PADA+TIKUS+PUTIH+JANTAN+(Rattus+norvegicus)+GALUR+Sprague+dawley+YANG+DIPAPARKAN+ASAP+ROKOK.++Fakultas+Kedokteran+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F58903%2F