?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=IDENTIFIKASI+SINGLE+NUCLEOTIDE+POLYMORPHISM+KODON+1042%0D%0AGEN+Pfmdr1+PADA+PENDERITA+Malaria+falciparum+DI+KABUPATEN%0D%0APESAWARAN%0D%0A&rft.creator=Fitria+Putridewi+Abidin%2C+1518011083&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+Belakang%3A+Plasmodium+falciparum+merupakan+penyebab+penyakit+malaria%0D%0Afalciparum+yang+resisten+terhadap+obat+antimalaria+klorokuin+disebabkan+adanya%0D%0Amutasi+genetik.+Adanya+Single+Nucleotide+Polymorphism+kodon+1042+gen%0D%0APlasmodium+falciparum+Multidrug+Resistance+1+(Pfmdr1)+dapat+menjadi+penanda%0D%0Agenetik+resistensi+obat.+Teknologi+Polymerase+Chain+Reaction+(PCR)+dan%0D%0Asekuensing+digunakan+untuk+mendeteksi+polimorfisme+gen+secara+spesifik+dan%0D%0Aakurat.%0D%0AMetode%3A+Jenis+penelitian+ini+menggunakan+rancangan+penelitian+survey+dan%0D%0Abersifat+deskriptif.+Sampel+penelitian+diperoleh+dari+Bahan+Biologi+Tersimpan%0D%0A(BBT)+sebanyak+22+sampel.+Pemeriksaan+dilakukan+dengan+menggunakan+metode%0D%0APCR+yang+dilanjutkan+dengan+sekuensing+untuk+mendeteksi+polimorfisme.%0D%0AHasil%3A+Sebanyak+12+dari+22+sampel+telah+berhasil+dilakukan+Nested+PCR+dan%0D%0Asekuensing+dengan+hasil+kodon+1042+gen+Pfmdr1+pada+sampel+bersifat+wild-type.%0D%0AKesimpulan%3A+Tidak+terdapat+Single+Nucleotide+Polymorphism+kodon+1042+gen%0D%0APlasmodium+falciparum+Multidrug+Resistance+1+(Pfmdr1)%0D%0AKata+Kunci%3A+Kodon%2C+Plasmodium+falciparum+Multidrug+Resistance+1+(Pfmdr1)%2C%0D%0APolymerase+Chain+Reaction+(PCR).%0D%0A%0D%0ABackground%3A+Plasmodium+falciparum+caused+malaria+falciparum+which+is+resistant%0D%0Ato+chloroquine+antimalarial+drugs+due+to+genetic+mutations.+The+presence+of+Single%0D%0ANucleotide+Polymorphism+codon+1042+of+Plasmodium+falciparum+Multidrug%0D%0AResistance+1+(Pfmdr1)+gene+can+be+a+genetic+marker+of+drug+resistance.+Polymerase%0D%0AChain+Reaction+(PCR)+and+sequencing+are+used+to+detect+gene+polymorphism%0D%0Aspesifically+and+accurately.%0D%0AMethod%3A.+Research+used+a+survey+research+design+with+descriptive+method.+There%0D%0Aare+22+Archived+Biological+Materials+(ABM)+used+as+sample.+The+examination+was%0D%0Acarried+out+using+the+PCR+method%2C+followed+by+sequencing+to+detect+polymorphism.%0D%0AResult%3A+12+from+22+samples+had+been+successfully+Nested+PCR+and+sequenced.+The%0D%0Acharacteristic+of+codon+1042+Pfmdr1+gene+are+proved+wild-type+in+all+sample.%0D%0AConclusion%3A+There+are+no+Single+Nucleotide+Polymorphism+codon+1042%0D%0APlasmodium+falciparum+Multidrug+Resistance+1+(Pfmdr1).%0D%0AKeyword%3A+Codon%2C+Plasmodium+falciparum+Multidrug+Resistance+1+(Pfmdr1)%2C%0D%0APolymerase+Chain+Reaction+(PCR).&rft.publisher=Fakultas+Kedokteran+&rft.date=2019-01-22&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58917%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58917%2F2%2FSKRIPSI%2520FULL%2520TEKS.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58917%2F3%2FSKRIPSI%2520FULL%2520TEKS%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Fitria+Putridewi+Abidin%2C+1518011083++(2019)+IDENTIFIKASI+SINGLE+NUCLEOTIDE+POLYMORPHISM+KODON+1042+GEN+Pfmdr1+PADA+PENDERITA+Malaria+falciparum+DI+KABUPATEN+PESAWARAN.++Fakultas+Kedokteran+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F58917%2F