?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+EKSTRAK+KULIT+MANGGIS+(Garcinia+mangostana+L)%0D%0ATERHADAP+JUMLAH+RERATA+SPERMATOSIT+PRIMER+TIKUS%0D%0APUTIH+JANTAN+(Rattus+novergicus)+GALUR+Sprague+dawley%0D%0AYANG+DIINDUKSI+PLUMBUM+ASETAT&rft.creator=I+Gede+Sugiana+Karaeng%2C+1418011101&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+Belakang%3A+Kandungan+logam+Pb+dalam+gas+buang+kendaraan+bermotor%0D%0Adapat+membahayakan+kesehatan+dan+merusak+kesehatan+dan+merusak+lingkungan.%0D%0ALogam+Pb+sebagai+radikal+bebas+dapat+memicu+stress+oksidatif.+Stress+oksidatif%0D%0Amenyebabkan+peningkatan+reactive+oxygen+species+(ROS)+dan+kerusakan%0D%0Amembran+spermatozoa.+Antioksidan+merupakan+salah+satu+senyawa+yang+dapat%0D%0Adigunakan+untuk+menanggulangi+permasalahan+ini%2C+diantaranya+yaitu+ekstrak+kulit%0D%0Amanggis+yang+memiliki+kandangan+antioksidan+sebagai+penangkal+radikal+bebas.%0D%0AMetode%3A+Penelitian+eksperimental+ini+dilakukan+selama+14+hari.+Sebanyak+25+ekor%0D%0Atikus+jantan+(Spragua+dawley)+dibagi+kedalam+5+kelompok+perlakuan%3A+K%2B+(tanpa%0D%0Aperlakuan)%2C+K-%2C+P1%2C+P2%2C+P3+(dipapar+plumbum+asetat+dosis+0%2C35gram%2FKgBB+dan%0D%0Adiberikan+secara+berturut+turut+ekstrak+kulit+manggis+dengan+dosis+0%2C+50%2C+100%2C+200%0D%0Amg%2FKgBB.+Rerata+sprematosit+primer+dihitung+menggunakan+mikroskop+dengan%0D%0Aperbesaran+400x.+Data+dianalisis+dengan+uji+One+Way+ANOVA.%0D%0AHasil%3A+Hasil+analisis+dari+perlakuan+(P1%2C+P2%2C+dan+P3)+menunjukkan+ekstrak+kulit%0D%0Amanggis+belum+mampu+meningkatkan+rerata+spematosit+primer+dari+tikus+putih%0D%0Ajantan.+Rerata+spermatosit+primer+yang+diperoleh+adalah+133%2C2+%C2%B1+24+(K%2B)%2C+71%2C85+%C2%B1%0D%0A16%2C9+(K-)%2C+72%2C0+%C2%B1+17%2C3+(P1)%2C+29%2C2+%C2%B1+9%2C3+(P2)%2C+43%2C3+%C2%B1+6%2C82+(P3).+Uji+post+hoc+LSD%0D%0Amenunjukan+perbedaan+bermakna+dari+tiap+kelompok+perlakuan.%0D%0AKesimpulan%3A+Ekstrak+kulit+menggis+belum+mampu+meningkatkan+jumlah+rerata%0D%0Aspermatosit+primer+tikus+putih+jantan+yang+terpapar+plumbum+asetat.%0D%0AKata+Kunci%3A+plumbum+asetat%2C+spermatosit+primer%2C+ekstrak+kulit+manggis%2C+ROS.%0D%0A%0D%0ABackground%3A+The+Pb+metal+content+in+motor+vehicle+exhaust+gases+can+danger%0D%0Ahealth+and+damage+the+environment.+Pb+metal+as+a+free+radical+can+trigger%0D%0Aoxidative+stress.+Oxidative+stress+causes+an+increase+in+reactive+oxygen+species%0D%0A(ROS)+and+damage+to+the+spermatozoa+membrane.+Antioxidants+are+one+of+the%0D%0Acompounds+that+can+be+used+to+overcome+this+problem%2C+including+the+mangosteen%0D%0Apeel+extract+which+has+a+view+of+antioxidants+as+an+antidote+to+free+radicals.%0D%0AMethod%3A+This+experimental+was+conducted+for+14+days.+25+male+rats+(Spragua%0D%0Adawley)+were+divided+into+5+treatment+groups%3A+K+%2B+(without+treatment)%2C+K-%2C+P1%2C%0D%0AP2%2C+P3+(exposed+to+plumbum+acetate+dose+of+0.35gram+%2F+KgBB+and+given%0D%0Aconsecutively+mangosteen+peel+extract+at+a+dose+of+0+%2C+50%2C+100%2C+200+mg+%2F+KgBB%2C%0D%0Amean+primary+sprematocytes+were+calculated+using+a+microscope+with+400x%0D%0Amagnification+Data+were+analyzed+by+the+One+Way+ANOVA.%0D%0AResults%3A+The+results+of+the+treatment+analysis+(P1%2C+P2%2C+and+P3)+showed+that+the%0D%0Amangosteen+peel+extract+had+not+been+able+to+increase+mean+primary%0D%0Aspematocytes+from+male+white+rats%2C+mean+that+of+primary+spermatocytes+obtained%0D%0Awas+133.2+%C2%B1+24+(K%2B)%2C+71.85+%C2%B1+16.9+(K-)%2C+72.0+%C2%B1+17.3+(P1)%2C+29.2+%C2%B1+9.3+(P2)%2C+43.3+%C2%B1%0D%0A6.82+(P3)test+post+hoc+LSD+showed+significant+differences+from+each+treatment%0D%0Agroup.%0D%0AConclusion%3A+The+extract+of+the+Mangosteen+skin+was+not+yet+able+to+increase%0D%0AAverage+of+primary+spermatocytes+of+male+white+rats+exposed+to+plumbum%0D%0Aacetate.%0D%0AKeywords%3A+plumbum+acetate%2C+primary+spermatocytes%2C+mangosteen+peel+extract%2C%0D%0AROS.&rft.publisher=Fakultas+Kedokteran+&rft.date=2019-07-16&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58982%2F1%2F1.%2520ABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58982%2F2%2F2.%2520SKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58982%2F3%2F3.%2520SKRIPSI%2520FULL%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++I+Gede+Sugiana+Karaeng%2C+1418011101++(2019)+PENGARUH+EKSTRAK+KULIT+MANGGIS+(Garcinia+mangostana+L)+TERHADAP+JUMLAH+RERATA+SPERMATOSIT+PRIMER+TIKUS+PUTIH+JANTAN+(Rattus+novergicus)+GALUR+Sprague+dawley+YANG+DIINDUKSI+PLUMBUM+ASETAT.++Fakultas+Kedokteran+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F58982%2F