?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+EKSTRAK+ETANOL+BIJI+LABU+(Cucurbita%0D%0Amoschata+Durch)+TERHADAP+LAMA+WAKTU+TIDUR+MENCIT+YANG%0D%0ADIINDUKSI+FENOBARBITAL&rft.creator=Jihan+Nur+Pratiwi%2C+1618011003&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+Belakang+%3A+Gangguan+tidur+merupakan+gabungan+kondisi+pada+kualitas%2C%0D%0Akuantitas%2C+dan+waktu+tidur%2C+yang+dapat+memberikan+dampak+buruk+bagi+kesehatan%0D%0Afisik+dan+psikologi+manusia.+Tidur+diatur+oleh+sistem+aktifitas+retikular+yang%0D%0Adipengaruhi+oleh+neurotransmiter+triptofan.+Biji+labu+merupakan+bahan+alam%0D%0Adengan+kandungan+triptofan+yang+tinggi%2C+triptofan+dapat+meningkatkan+kualitas%0D%0Atidur+dengan+memproduksi+serotonin+dan+melatonin+sebagai+inisiasi+tidur.%0D%0AMetode+%3A+Penelitian+menggunakan+kuasi+eksperimental+dengan+metode+post+test%0D%0Aonly+controlled+group+design.+Sampel+menggunakan+25+mencit+yang+dibagi+dalam%0D%0Alima+kelompok+yaitu+kontrol+negatif+(K0)+diberikan+NaCl+0%2C9%25%2C+kontrol+positif%0D%0A(K1)+diberikan+fenobarbital+40+mg%2FkgBB%2C+perlakuan+satu+(P1)+diberikan+ekstrak%0D%0Aetanol+biji+labu+40mg%2FgBB+dan+fenobarbital+40+mg%2FkgBB%2C+perlakuan+dua+(P2)%0D%0Adiberikan+ekstrak+etanol+biji+labu+80+mg%2FkgBB+dan+fenobarbital+40+mg%2FkgBB%2C+perlakuan+tiga+(P3)+diberikan+ekstrak+etanol+biji+labu+160+mg%2FgBB+dan%0D%0Afenobarbital+40+mg%2Fkg.+Waktu+tidur+mencit+diukur+mulai+dari+mencit+kehilangan%0D%0Areflek+righting+dan+kembali+dapat+melakukan+reflek+righting.+Hasil+%3A+Penelitian+ini+menunjukan+adanya+peningkatan+lama+waktu+tidur+mencit%0D%0Ayang+diberikan+ekstrak+etanol+biji+labu+pada+dosis+40+mg%2FgBB%2C+80+mg%2FgBB%2C+dan%0D%0A120+mg%2FgBB+dengan+waktu+tidur+tertinggi+pada+dosis+120+mg%2FgBB+yaitu+sebesar%0D%0A95%2C9+menit.%0D%0ASimpulan+%3A+Pemberian+ekstrak+etanol+biji+labu+dapat+meningkatkan+lama+waktu%0D%0Atidur+mencit.%0D%0AKata+Kunci+%3A+Biji+labu%2C+fenobarbital%2C+tidur%2C+triptofan%0D%0A%0D%0ABackground+%3A+Sleep+disorders+are+a+combination+of+quality%2C+quantity%2C+and+sleep%0D%0Atime%2C+which+can+provide+adverse+effect+for+physical+health+and+human+psychology.%0D%0ASleep+is+regulated+by+the+reticular+system+which+depend+on+tryptophan%0D%0Aneurotransmitters.+Pumpkin+seeds+are+natural+source+contain+with+highest%0D%0Atryptophan%2C+tryptophan+can+improve+sleep+quality+by+producing+serotonin+and%0D%0Amelatonin+as+initiators+of+sleep.%0D%0AMethod+%3A+This+study+used+a+quasi-experimental+research+method+with+post+test%0D%0Aonly+controlled+group+design.+The+sample+were+25+mice+divided+into+five+groups%2C%0D%0Anegative+control+(K0)+given+NaCl+0.9%25%2C+positive+control+(K1)+given+phenobarbital%0D%0A40+mg%2FkgBB%2C+first+treatment+(P1)+was+given+ethanol+extract+of+40+mg%2FgBB%0D%0Apumpkin+seeds+and+phenobarbital+40+mg%2FkgBB%2C+second+treatment+(P2)+was+given%0D%0Aethanol+extract+of+pumpkin+seeds+80+mg%2FgBB+and+phenobarbital+40+mg%2FkgBB%2C+third+treatment+(P3)+were+given+ethanol+extract+of+160+mg%2FgBB+pumpkin+seeds%0D%0Aand+phenobarbital+40+mg%2FkgBB.+Bedtime+of+mice+was+measure+starting+from+the%0D%0Amice+lose+the+righting+reflex+and+re-doing+the+righting+reflex.+Results+%3A+This+study+showed+an+increase+in+sleep+duration+of+mice+given+pumpkin%0D%0Aseed+ethanol+extract+at+dose+of+40+mg%2FgBB%2C+80+mg%2FgBB%2C+and+120+mg%2FgBB+with+the%0D%0Ahighest+sleep+duration+at+dose+of+120+mg%2FgBB+for+about+95.9+minutes.%0D%0AConclusion+%3A+Pumpkin+seed+ethanol+extract+extends+mice+sleep+time%0D%0AKeywords+%3A+Pumpkin+seed%2C+phenobarbital%2C+sleep%2C+tryptophan&rft.publisher=Fakultas+Kedokteran+&rft.date=2019-12-31&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58990%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58990%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Jihan+Nur+Pratiwi%2C+1618011003++(2019)+PENGARUH+PEMBERIAN+EKSTRAK+ETANOL+BIJI+LABU+(Cucurbita+moschata+Durch)+TERHADAP+LAMA+WAKTU+TIDUR+MENCIT+YANG+DIINDUKSI+FENOBARBITAL.++Fakultas+Kedokteran+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F58990%2F