?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+VITAMIN+C+TERHADAP+KOORDINASI%0D%0AMOTORIK+TIKUS+PUTIH+(Rattus+novergicus)+JANTAN%0D%0AGALUR+Sprague+dawley+YANG+DI+INDUKSI%0D%0AMONOSODIUM+GLUTAMAT&rft.creator=Karin+indah+Kurniawati%2C+1618011069&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+Belakang%3A+Monosodium+glutamat+(MSG)+dapat+menyebabkan+stimulasi+yang%0D%0Aberlebihan+terhadap+reseptor+glutamat+sehingga+dapat+terjadi+peningkatan+konsentrasi%0D%0ACa2%2B+yang+diduga+menjadi+awal+penyebab+nekrosis+sel+dan+memicu+produksi+Reactive%0D%0AOxygen+Species+(ROS).+Konsumsi+MSG+yang+berlebihan+berkaitan+dengan+gangguan%0D%0Akoordinasi+motorik.+Vitamin+C+telah+terbukti+memainkan+peran+penting+dalam%0D%0Amempertahankan+kemampuan+motorik.+Tujuan+penelitian+ini+yaitu+mengetahui+pengaruh%0D%0Apemberian+vitamin+C+terhadap+koordinasi+motorik+tikus+putih+(Rattus+novergicus)+jantan%0D%0Agalur+Sprague+dawley+yang+di+induksi+MSG.%0D%0AMetode%3A+Penelitian+ini+adalah+studi+eksperimental+dengan+rancangan+post+test+only%0D%0Acontrol+group+design.+Sampel+yang+digunakan+sebanyak+30+ekor+dan+dibagi+ke+dalam+5%0D%0Akelompok+dengan+tiap+kelompok+terdiri+dari+6+ekor+tikus.+Setelah+diberikan+perlakuan%0D%0Aselama+21+hari%2C+koordinasi+motorik+dinilai+dengan+perangkat+balance+beam+test+yang%0D%0Adilewati+tikus.+Data+dianalisis+dengan+uji+one+way+ANOVA+dan+dilanjutkan+dengan+uji%0D%0Apost+hoc+LSD.%0D%0AHasil%3A+Hasil+rerata+balance+beam+test+secara+berurutan+setiap+kelompok+K(-)%2C+K(%2B)%2C+P1%2C%0D%0AP2%2C+P3+adalah+12%2C08%C2%B19%2C6+detik%3B+41%2C75%C2%B118%2C35+detik%3B+18%2C5%C2%B112%2C27+detik%3B+17%2C7%C2%B111%2C12+detik%3B%0D%0A38%2C33%C2%B119%2C10+detik.+Hasil+analisis+pada+perangkat+balance+beam+yaitu+data+tersebar+normal%0D%0Adan+homogen+dengan+p%3D0%2C005+(p%3C0%2C05).%0D%0ASimpulan%3A+Terdapat+pengaruh+pada+pemberian+vitamin+c+terhadap+koordinasi+motorik%0D%0Atikus+putih+jantan+(Rattus+novergicus)+galur+Sprague+dawley+yang+diinduksi+MSG%0D%0A(p%3D0%2C005).%0D%0AKata+Kunci%3A+balance+beam+test%2C+koordinasi+motorik%2C+MSG%2C+Rattus+novergicus%2C+vitamin+C%0D%0A%0D%0ABackground%3A+Monosodium+glutamate+(MSG)+can+causes+excessive+stimulation+of%0D%0Aglutamate+receptors+so+that+an+increase+in+Ca2%2B+concentration+is+thought+to+be+the+initial%0D%0Acause+of+cell+necrosis+and+triggers+the+production+of+Reactive+Oxygen+Species+(ROS).%0D%0AExcessive+consumption+of+MSG+is+associated+with+impaired+motor+coordination.+Vitamin%0D%0AC+has+been+shown+to+play+an+important+role+in+maintaining+motor+skills.+The+purpose+of%0D%0Athis+study+was+to+determine+the+effect+of+vitamin+C+on+motor+coordination+of+white+rats%0D%0A(Rattus+novergicus)+Sprague+dawley+strain+induced+by+MSG.%0D%0AMethod%3A+This+research+is+an+experimental+study+with+a+post+test+only+control+group%0D%0Adesign.+The+samples+used+were+30+animals+which+were+divided+into+5+groups+with+each%0D%0Agroup+consisting+of+6+rats.+After+being+treated+for+21+days%2C+motor+coordination+was%0D%0Aassessed+with+balance+beam+test+device+that+the+rats+passed.+Data+were+analyzed+by+one%0D%0Away+ANOVA+test+and+continued+with+post+hoc+LSD+test.%0D%0AResults%3A+The+mean+balance+beam+test+results+in+sequence+for+each+group+K+(-)%2C+K+(%2B)%2C+P1%2C%0D%0AP2%2C+P3+were+12%2C08%C2%B19%2C6+seconds%3B+41%2C75%C2%B118%2C35+seconds%3B+18%2C5%C2%B112%2C27+seconds%3B+17%2C7%C2%B111%2C12%0D%0Aseconds%3B+38%2C33%C2%B119%2C10+seconds.+seconds.+The+results+of+the+analysis+on+the+balance+beam%0D%0Adevice+are+normally+distributed+and+homogeneous+data+with+p+%3D+0.005+(p+%3C0.05).%0D%0AConclusion%3A+There+is+effect+on+the+administration+of+vitamin+C+to+the+motor+coordination%0D%0Aof+male+white+rats+(Rattus+novergicus)+Sprague+dawley+strain+induced+by+MSG%0D%0A(p%3D0%2C005).%0D%0AKeywords%3A+balance+beam+test%2C+motor+coordination%2C+MSG%2C+Rattus+novergicus%2C+vitamin+C&rft.publisher=Fakultas+Kedokteran+&rft.date=2019-12-30&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58994%2F1%2FABSTRAK%2520%2528INGGRIS%2520_%2520INDONESIA%2529.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58994%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F58994%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Karin+indah+Kurniawati%2C+1618011069++(2019)+PENGARUH+PEMBERIAN+VITAMIN+C+TERHADAP+KOORDINASI+MOTORIK+TIKUS+PUTIH+(Rattus+novergicus)+JANTAN+GALUR+Sprague+dawley+YANG+DI+INDUKSI+MONOSODIUM+GLUTAMAT.++Fakultas+Kedokteran+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F58994%2F