?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PERBEDAAN+WAKTU+PENYEMBUHAN+LUKA+POST+HECTING%0D%0ASECARA+MAKROSKOPIS+ANTARA+PEMBERIAN+TOPIKAL+EKSTRAK%0D%0ASEL+PUNCA+MESENKIMAL+TALI+PUSAT+MANUSIA+DENGAN%0D%0ACENTELLA+ASIATICA+PADA+TIKUS+PUTIH+JANTAN%0D%0A(RATTUS+NORVEGICUS)+GALUR+SPRAGUE+DAWLEY&rft.creator=Nadia+Gustria+Dini%2C+1518011049&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+Belakang%3A+Penyembuhan+luka+adalah+hal+yang+penting+karena+kulit+memiliki%0D%0Afungsi+spesifik+bagi+tubuh.+Ketika+terjadi+luka%2C+maka+fungsi+tersebut+tidak+dapat%0D%0Aberjalan+dengan+baik.+Centella+asiatica+dapat+merangsang+fibroblas+agar%0D%0Aberproliferasi+dan+menstimulasi+sintesis+kolagen.+Terdapat+juga+terapi+gen+yang%0D%0Asedang+dimanfaatkan+saat+ini+yaitu+sel+punca.+Sel+punca+adalah+sel+yang+menjadi%0D%0Aawal+mula+dari+pertumbuhan+sel+lain+yang+menyusun+keseluruhan+tubuh+organisme.%0D%0AMetode%3A+Penelitian+ini+merupakan+penilitian+eksperimental+laboratorik+yang%0D%0Abertujuan+untuk+mengetahui+perbedaan+penyembuhan+luka+antara+pemberian%0D%0Atopikal+ekstrak+sel+punca+mesenkimal+tali+pusat+manusia+dengan+Centella+asiatica%0D%0Ayang+meliputi+waktu+penyembuhan+luka%2C+infeksi+lokal%2C+dan+reaksi+alergi.+Penelitian%0D%0Aini+menggunakan+3+kelompok+perlakuan+yang+terdiri+dari%3A+(1)+kelompok+kontrol%0D%0Anegatif+(K)+Povidine+iodine%2C+(2)+kelompok+perlakuan+1+(P1)+ekstrak+sel+punca%0D%0Amesenkimal%2C+dan+(3)+kelompok+perlakuan+2+(P2)+ekstrak+Centella+asiatica+dimana%0D%0Amasing-masing+kelompok+terdiri+dari+6+sampel.%0D%0AHasil%3A+Pada+penelitian+ini+didapatkan+nilai+sigma+sebesar+0%2C049+(%3C0%2C05)+yang+dapat%0D%0Adisimpulkan+bahwa+terdapat+perbedaan+rerata+pada+kelompok+kontrol+dan%0D%0Akelompok+perlakuan.+Selanjutnya+analisis+dilanjutkan+menggunakan+uji+post+hoc%0D%0ALSD+untuk+mengetahui+perbandingan+antar+kelompok+perlakuan+dan+didapatkan%0D%0Ahasil+perbedaan+rerata+(sigma+%3C0%2C05)+ditemukan+pada+kelompok+kontrol+terhadap%0D%0Akelompok+perlakuan+1+dan+kelompok+perlakuan+2%2C+namun+tidak+didapatkan+adanya%0D%0Aperbedaan+rerata+pada+kelompok+perlakuan+1+terhadap+kelompok+perlakuan+2.%0D%0ASimpulan%3A+Terdapat+perbedaan+waktu%2C+infeksi+lokal%2C+dan+tidak+terdapat+reaksi%0D%0Aalergi+pada+penyembuhan+luka+post+hecting+antara+pemberian+topikal+ekstrak+sel%0D%0Apunca+mesenkimal+tali+pusat+manusia+maupun+Centella+asiatica+pada+tikus+putih%0D%0Ajantan+(Rattus+norvegicus)+galur+Sprague+dawley.%0D%0AKata+Kunci%3A+Penyembuhan+luka%2C+Sel+punca+mesenkimal%2C+Centella+asiatica%2C+Skor%0D%0Anagaoka%0D%0A%0D%0ABackground%3A+Wound+healing+is+important+because+the+skin+has+specific+functions%0D%0Afor+the+body.+When+there+are+injuries+to+the+skin%2C+then+these+functions+can+not+run%0D%0Aas+they+should.+Centella+asiatica+could+stimulates+fibroblasts+to+proliferate+and%0D%0Astimulate+collagen+synthesis.+There+are+also+gene+therapy+methods+therapies+that%0D%0Acurrently+being+used+like+stem+cells.+Stem+cells+are+cells+that+start+from+the+growth%0D%0Aof+other+cells+that+can+be+the+whole+body+of+an+organism.%0D%0AMethod%3A+This+research+is+a+laboratory+experimental+study+that+aims+to+determine%0D%0Athe+differences+in+macroscopic+post+hecting+wound+healing+between+topical%0D%0Aadministration+of+human+umbilical+mesenchymal+stem+cell+extracts+with+Centella%0D%0Aasiatica+which+includes+wound+healing+time%2C+local+infection%2C+and+allergic+reactions.%0D%0AThis+study+used+3+treatment+groups+consisting+of%3A+(1)+negative+control+group+(K)%0D%0APovidine+iodine%2C+(2)+treatment+group+1+(P1)+mesenchymal+stem+cell%2C+and+(3)%0D%0Atreatment+group+2+(P2)+Centella+asiatica+extract+where+each+group+consisted+of+6%0D%0Asamples.%0D%0AResult%3A+In+this+study+dedicate+the+sigma+value+of+0.049+(%3C0.05)+which+can+be%0D%0Aconcluded+that+there+are+differences+in+the+mean+in+the+control+group+and+the%0D%0Atreatment+group.+Furthermore%2C+the+analysis+was+continued+using+the+post+hoc+LSD%0D%0Atest+to+find+out+the+comparison+between+treatment+groups+and+the+results+of+the%0D%0Amean+difference+(sigma+%3C0.05)+were+found+in+the+control+group+against+treatment%0D%0Agroup+1+and+treatment+group+2%2C+but+there+were+no+mean+differences+in+treatment%0D%0Agroup+1+against+treatment+group+2.%0D%0AConclusion%3A+There+is+a+time+difference%2C+local+infection%2C+and+no+allergic+reaction+in%0D%0Apost+hecting+wound+healing+between+topical+administration+of+human+umbilical%0D%0Amesenchymal+stem+cell+extract+and+Centella+asiatica+in+white+male+rats+(Rattus%0D%0Anorvegicus)+Sprague+dawley+strain.%0D%0AKeywords%3A+Wound+healing%2C+Mesenchymal+stem+cell%2C+Centella+asiatica%2C+Nagaoka%0D%0Ascore&rft.publisher=Fakultas+Kedokteran+&rft.date=2019-10-23&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F59167%2F1%2FABSTRAK-ABSTRACT.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F59167%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=h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