?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+EKSTRAK+TEH+HIJAU+(Cammelia+Sinesis)%0D%0ATERHADAP+GAMBARAN+HISTOPATOLOGI+PARU-PARU+PADA%0D%0ATIKUS+PUTIH+JANTAN+GALUR+Sprague+Dawley+YANG+DI+PAPAR+UAP%0D%0AROKOK+ELEKTRONIK&rft.creator=Ni+Putu+Sari+Widiyani%2C+1418011150&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+belakang%3A+Rokok+elektronik+memiliki+kandungan+yang+bersifat+toksik+bagi+tubuh%0D%0Asehingga+dapat+menyebabkan+penyakit+saluran+nafas+dan+paru-paru.+Teh+hijau+merupakan%0D%0Asumber+kaya+polifenol+yang+memiliki+peran+ekstrak+teh+hijau+sebagai+antioksidan+dalam%0D%0Amencegah+terjadinya+stres+oksidatif.+Sehingga+pada+penelitian+ini+bertujuan+untuk+melihat%0D%0Agambaran+histologi+paru-paru+tikus+putih+yang+dipapar+dengan+uap+rokok+elektronik+dan%0D%0Adiberikan+ekstrak+teh+hijau+dalam+kurun+waktu+dan+dosis+tertentu.%0D%0AMetode%3A+Penelitian+menggunakan+rancangan+eksperimen+murni+menggunakan+30+tikus%0D%0Aputih+galur+Sprague+Dawley+yang+di+bagi+dalam+6+kelompok+yaitu+3+kelompok+kontrol%0D%0Adan+3+kelompok+perlakuan.+Pada+kelompok+kontrol%2C+diberikan+perlakuan+biasa%2C+paparan%0D%0Arokok+elektrik+dan+paparan+rokok+konvensional.+Pada+kelompok+perlakuan%2C+mencit%0D%0Adiberikan+injeksi+peritoneal+ekstrak+teh+hijau+masing-masing+sebanyak+50+mg%2FkgBB%2C+100%0D%0Amg%2FkgBB%2C+dan+200+mg%2FkgBB.+Setelah+14+hari+perlakuan%2C+hari+ke-15+mencit+di+euthanasia%0D%0Adan+diambil+preparat.%0D%0AHasil%3A+Terdapat+perubahan+kerusakan+histopatologi+pada+seluruh+sampel+dimana+terjadi%0D%0Aperbedaan+yang+signifikan+pada+seluruh+kelompok+perlakuan+dan+kontrol+(p%3D0%2C000)%2C%0D%0Atetapi+tidak+signifikan+pada+kelompok+perlakuan+dengan+nilai+P1+terhadap+K2+dengan+p%3D%0D%0A0%2C163.%0D%0ADiskusi%3A+Penggunaan+rokok+elektronik+meningkatkan+kejadian+stress+oksidatif+sehingga%0D%0Aterjadi+respon+inflamasi+pada+jaringan+paru-paru.+Kerusakan+dapat+dikurangi+dengan%0D%0Apemberian+teh+hijau+yang+berperan+sebagai+anti+oksidan.%0D%0ASimpulan%3A+Terdapat+perbedaan+antara+pemberian+paparan+uap+rokok+elektronik+terhadap%0D%0Aperubahan+struktur+histologis+trakea+tikus+putih+(Ratus+novergicus)+galur+Sprague+dawley%2C%0D%0Aterdapat+perbedaan+antara+pemberian+ekstrak+teh+hijau+terhadap+perubahan+struktur%0D%0Ahistologis+trakea+tikus+yang+dipapar+uap+rokok+elektronik+pada+dosis+100+mg%2FkgBB+dan%0D%0A200+mg%2FkgBB.%0D%0AKata+kunci%3A+ekstrak+teh+hijau%2C+histopatologi%2C+paru-paru%2C+rokok+eletronik%2C+sprague+dawley%0D%0A%0D%0ABackground%3A+Electronic+cigarettes+contain+contents+that+are+toxic+to+the+body+so+that+they%0D%0Acan+cause+respiratory+and+lung+diseases.+Green+tea+is+a+rich+source+of+polyphenols+which%0D%0Ahave+the+role+of+green+tea+extract+as+an+antioxidant+in+preventing+oxidative+stress.+So+that%0D%0Ain+this+study+aims+to+look+at+the+histology+of+lung+in+white+rats+exposed+to+electronic%0D%0Acigarette+vapor+and+given+green+tea+extract+in+a+certain+period+and+dose.%0D%0AMethod%3A+The+study+used+a+pure+experimental+design+using+30+Sprague+Dawley+strain%0D%0Awhite+rats+which+were+divided+into+6+groups%2C+namely+3+control+groups+and+3+treatment%0D%0Agroups.+In+the+control+group%2C+given+regular+treatment%2C+exposure+to+electric+cigarettes+and%0D%0Aexposure+to+conventional+cigarettes.+In+the+treatment+group%2C+mice+were+given+peritoneal%0D%0Ainjection+of+green+tea+extract+each+of+50+mg%2Fkg+body+weight%2C+100+mg%2Fkg+body+weight%2C+and%0D%0A200+mg%2Fkg+body+weight.+After+14+days+of+treatment%2C+the+15th+day+of+mice+was+euthanized%0D%0Aand+preparations+were+taken.%0D%0AResults%3A+There+was+a+change+in+histopathological+damage+in+all+samples+where+there+were%0D%0Asignificant+differences+in+all+treatment+and+control+groups+(p%3D0%2C000)%2C+but+not+significantly%0D%0Ain+the+treatment+group+with+a+value+of+P1+to+K2+with+p%3D0.163.%0D%0ADiscussion%3A+The+use+of+electronic+cigarettes+increases+the+incidence+of+oxidative+stress%0D%0Aresulting+in+an+inflammatory+response+in+lung+tissue.+Damage+can+be+reduced+by+giving%0D%0Agreen+tea+which+acts+as+an+anti-oxidant.%0D%0AConclusion%3A+There+is+a+difference+between+the+administration+of+electronic+cigarette%0D%0Avapor+exposure+to+changes+in+tracheal+histological+structure+of+white+rats+(Ratus%0D%0Anovergicus)+Sprague+Dawley+strain%2C+there+is+a+difference+between+the+administration+of%0D%0Agreen+tea+extract+to+changes+in+histologic+histological+structure+of+rats+exposed+to%0D%0Aelectronic+cigarette+steam+at+a+dose+of+100+mg%2FkgBB+and+200+mg%2FkgBB.%0D%0AKeywords%3A+electronic+cigarette%2C+green+tea+exstract%2C+histopathology%2C+lung%2C+sprague+dawley&rft.publisher=Fakultas+Kedokteran+&rft.date=2019-07-10&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F59334%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F59334%2F2%2FSKRIPSI%2520TANPA%2520PEMBAHASAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.uni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