?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+EKSTRAK+KULIT+BATANG+BAKAU%0D%0AMINYAK+(Rhizophora+apiculata)+ETANOL+95+%25+TERHADAP%0D%0AGAMBARAN+HISTOPATOLOGI+ARTERI+KORONARIA+TIKUS+PUTIH%0D%0A(Rattus+novergicus)+JANTAN+GALUR+Sprague+dawley+YANG%0D%0ADIPAPARKAN+ASAP+ROKOK&rft.creator=Nicholas+Alfa%2C+1518011096&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+Belakang%3A+Indonesia+menenmpati+peringkat+pertama+sebagai+negara%0D%0Adengan+jumlah+perokok+terbesar+di+kawasan+ASEAN.+Hal+ini+tentunya+sangat%0D%0Amemprihatinkan+2+dari+3+orang+Indoneisa+merupakan+seorang+perokok.+Penyakit%0D%0Ajantung+koroner+(PJK)+merupakan+penyebab+kematian+tertinggi+di+Indonesia%0D%0Asetelah+stroke%2C+yakni+12%2C9%25.+Rhizophora+apiculata+memiliki+kandungan+tanin%2C%0D%0Aalkaloid%2C+dan+flavonoid+yang+dapat+mencegah+radikal+bebas.+Dari+uraian+diatas%2C%0D%0Apenulis+ingin+menggali+potensi+antioksidan+yang+terdapat+dalam+bakau+dengan%0D%0Amempelajari+pengaruh+pemberian+ekstrak+kulit+bakau+minyak+(Rhizophora%0D%0Aapiculata)+dalam+melindungi+arteri+koroner+tikus+dari+paparan+asap+rokok.%0D%0AMetode%3A+Penelitian+ini+adalah+penelitan+eksperimental.+Sampel+yang+digunakan%0D%0Aadalah+tikus+putih+jantan+(Rattus+novergicus)+galur+Sprague+dawley+yang+terdiri%0D%0Adari+5+kelompok%2C+masing+masing+kelompok+terdiri+dari+5+ekor+tikus+dan+1%0D%0Acadangan.+Dosis+ekstrak+bakau+yang+digunakan+pada+P1+adalah+28%2C275+mg%2Fkgbb%2C%0D%0AP2%3A+56%2C55+mg%2Fkgbb%2C+P3%3A+113%2C1+mg%2Fkgbb.+Analisis+statistik+yang+digunakan+yaitu%0D%0Auji+One+Way+Anova+dengan+post+hoc+Bonferroni.%0D%0AHasil%3A+Rerata+diameter+arteri+koronaria+memiliki+hasil+tidak+bermakna+pada+semua%0D%0Akelompok+perlakuan.+Rerata+tebal+dinding+arteri+koronaria+memiliki+hasil%0D%0Abermakna+pada+semua+kelompok+perlakuan.%0D%0AKesimpulan%3A+Ekstrak+kulit+batang+bakau+minyak+(Rhizophora+apiculata)+mampu%0D%0Amelindungi+arteri+koronaria+tikus+putih+jantan+(Rattus+novergicus)+galur+Sprague%0D%0Adawley+yang+dipaparkan+asap+rokok.+Dosis+optimal+ekstrak+kulit+batang+bakau%0D%0Aminyak+(Rhizophora+apiculata)+dalam+mencegah+penebalan+arteri+koronaria+tikus%0D%0Aputih+jantan+(Rattus+novergicus)+galur+Sprague+dawley+yang+dipaparkan+asap%0D%0Arokok+adalah+56%2C55+mg%2Fkgbb.%0D%0AKata+kunci%3A+asap+rokok%2C+antioksidan%2C+arteri+koronaria%2C+bakau+minyak%0D%0A%0D%0ABackground%3A+Indonesia+won+first+place+as+the+country+with+the+largest+number+of%0D%0Asmokers+in+the+ASEAN+region.+This+is+of+course+very+concerning+2+out+of+3%0D%0AIndonesians+are+smokers.+Coronary+heart+disease+(CHD)+is+the+highest+cause+of%0D%0Adeath+in+Indonesia+after+a+stroke%2C+which+is+12.9%25.+Rhizophora+apiculata+contains%0D%0Atannins%2C+alkaloids%2C+and+flavonoids+that+can+fight+free+radicals.+From+the+description%0D%0Aabove%2C+the+author+wants+to+explore+the+potential+of+antioxidants+found+in%0D%0Amangroves+by+studying+the+effect+of+giving+extract+mangrove+bark+(Rhizophora%0D%0Aapiculata)+in+protecting+rat+coronary+arteries+from+exposure+to+cigarette+smoke.%0D%0AMethod%3A+This+study+is+experimental+research.+The+sample+used+was+male+white%0D%0Arats+(Rattus+novergicus)+Sprague+Dawley+strain+which+divided+of+5+groups%2C+each%0D%0Agroup+consisting+of+5+rats+and+1+backup.+The+dosage+of+mangrove+extract+used+in%0D%0AP1+was+28.275+mg%2Fkgbb%2C+P2%3A+56.55+mg%2Fkgbb%2C+P3%3A+113.1+mg%2Fkgbb.+The+statistical%0D%0Aanalysis+used+One+Way+Anova+test+with+Bonferroni+post+hoc.%0D%0AResults%3A+The+mean+coronary+artery+diameter+had+no+significant+results+in+all%0D%0Atreatment+group.+The+mean+coronary+artery+wall+thickness+had+significant+results%0D%0Ain+all+treatment+groups.%0D%0AConclusion%3A+The+mangrove+bark+extract+(Rhizophora+apiculata)+is+able+to+protect%0D%0Athe+coronary+arteries+of+male+white+rats+(Rattus+novergicus)+Sprague+Dawley%0D%0Astrains+exposed+to+cigarette+smoke.+The+optimal+dose+of+mangrove+bark+extract%0D%0A(Rhizophora+apiculata)+in+preventing+thickening+of+the+coronary+arteries+of+male%0D%0Awhite+rats+(Rattus+novergicus)+Sprague+dawley+strains+exposed+to+cigarette+smoke%0D%0Ais+56.55+mg%2Fkgbb.%0D%0AKeywords%3A+cigarette+smoke%2C+antioxidants%2C+coronary+arteries%2C+mangroves&rft.publisher=Fakultas+Kedokteran+&rft.date=2019-01-18&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F59342%2F1%2FAbstrak%2520%2528Abstract%2529.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F59342%2F2%2FSkripsi%2520Full.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F59342%2F3%2FSkripsi%2520Tanpa%2520Bab%2520Pembahasan.pdf&rft.identifier=++Nicholas+Alfa%2C+1518011096++(2019)+PENGARUH+PEMBERIAN+EKSTRAK+KULIT+BATANG+BAKAU+MINYAK+(Rhizophora+apiculata)+ETANOL+95+%25+TERHADAP+GAMBARAN+HISTOPATOLOGI+ARTERI+KORONARIA+TIKUS+PUTIH+(Rattus+novergicus)+JANTAN+GALUR+Sprague+dawley+YANG+DIPAPARKAN+ASAP+ROKOK.++Fakultas+Kedokteran+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relat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