?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+MINUMAN+RINGAN+BERKARBONASI%0D%0ATERHADAP+GAMBARAN+HISTOPATOLOGI+HEPAR+TIKUS+PUTIH%0D%0A(Rattus+norvegicus)+JANTAN+GALUR+Sprague+dawley&rft.creator=Nikom+Sonia+Purohita%2C+1518011107&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+Belakang%3A+Minuman+ringan+berkarbonasi+adalah+minuman+yang+dibuat+dengan%0D%0Amenyerap+karbon+dioksida+dalam+air+minum+dengan+atau+tanpa+berbagai+zat%0D%0Atambahan.+Konsumsi+minuman+ringan+berkarbonasi+menunjukkan+peningkatan+yang%0D%0Asignifikan+di+dunia+termasuk+di+Indonesia+dan+dikaitkan+dengan+timbulnya+berbagai%0D%0Amasalah+kesehatan+yang+melibatkan+berbagai+organ+termasuk+hepar.+Penelitian+ini%0D%0Abertujuan+untuk+mengetahui+pengaruh+minuman+ringan+berkarbonasi+terhadap%0D%0Ahistopatologi+hepar+tikus.%0D%0AMetode%3A+Penelitian+ini+merupakan+penelitian+eksperimental+dengan+desain+post-test%0D%0Aonly+control+group+menggunakan+sampel+tikus+putih+(Rattus+norvegicus)+jantan+galur%0D%0ASprague+dawley+sebanyak+28+ekor+yang+dibagi+menjadi+4+kelompok.+K+diberi+aquades%0D%0Asecara+ad+libitum%2C+P1+diberi+minuman+ringan+berkarbonasi+dengan+dosis+3+ml%2Fhari%2C+P2%0D%0A6+ml%2Fhari%2C+dan+P3+dengan+dosis+12+ml%2Fhari+selama+30+hari.+Gambaran+kerusakan%0D%0Adinilai+dengan+skoring+Manja+Roenigk.%0D%0AHasil%3A+Rerata+skor+kerusakan+histopatologi+pada+K%3A+1%2C03%2C+P1%3A1%2C43%2C+P2%3A+1%2C73%2C+dan+P3%3A%0D%0A2%2C37.+Uji+statistik+yang+dilakukan+yaitu+uji+normalitas+Saphiro-Wilk+p%3D0%2C061%0D%0A(p%3E0%2C05)%2C+uji+homogenitas+Lavene+p%3D0%2C117+(p%3E0%2C05)%2C+dan+uji+One+Way+ANOVA%0D%0Ap%3D0%2C001+(p%3C+0%2C05).+Hasil+analisis+Post+Hoc+LSD+dengan+hasil+p%3C0%2C05+pada+semua%0D%0Akelompok.%0D%0ASimpulan%3A+Terdapat+pengaruh+pemberian+minuman+ringan+berkarbonasi+terhadap%0D%0Agambaran+histopatologi+hepar+tikus+putih+(Rattus+norvegicus)+jantan+galur+Sprague%0D%0Adawley.%0D%0AKata+Kunci%3A+hepar%2C+minuman+ringan+berkarbonasi%2C+perubahan+histopatologi%0D%0A%0D%0ABackground%3A+Carbonated+soft+drinks+are+beverages+made+by+absorbing+carbon%0D%0Adioxide+in+potable+water+with+or+without+various+added+substances.+Carbonated+soft%0D%0Adrinks+consumption+shows+a+significant+increase+in+the+world+including+in+Indonesia%0D%0Aand+have+been+associated+with+various+health+problems+involving+multiple+organs%0D%0Aincluding+the+liver.+The+aim+of+this+research+is+to+determine+the+effects+of+carbonated%0D%0Asoft+drink+administration+on+liver+histopathological+changes+in+rats.%0D%0AMethods%3A+This+research+is+a+post-test+only+control+group+experimental+study+using+28%0D%0Amale+rats+(Rattus+norvegicus)+Sprague+dawley+strain+which+divided+into+4+groups.+The%0D%0Acontrol+group+(K)+allowed+to+drink+aquades+ad+libitum%2C+P1+is+given+carbonated+soft%0D%0Adrinks+3+ml%2Fday%2C+P2+6+ml%2Fday%2C+and+P3+12+ml%2Fday+for+30+days.+Histopathological%0D%0Achanges+are+assessed+using+Manja+Roenigk's+scoring.%0D%0AResults%3A+The+average+of+histopathological+damage+in+group+K%3A1.03%2C+P1%3A1.43%2C+P2%3A1.73%2C%0D%0Aand+P3%3A2.37.+Test+of+normality+Saphiro-Wilk+results+in+p+value%3D+0.061+(p%3E0.05)%0D%0Afollowed+by+Lavene+homogenity+with+p%3D0.117+(p%3E0.05).+The+data+was+analysed+by%0D%0Ausing+One+Way+ANOVA+test+result+in+p%3D0.001+(p%3C0.05).+The+results+of+Post+Hoc%0D%0ALSD+analysis+are+p%3C0.05+in+all+groups.%0D%0AConclusion%3A+There+is+an+effect+of+carbonated+soft+drinks+administration+on+liver%0D%0Ahistopathological+changes+of+male+rats+(Rattus+norvegicus)+Sprague+dawley+strain.%0D%0AKeywords%3A+carbonated+soft+drink%2C+histopathological+changes%2C+liver&rft.publisher=Fakultas+Kedokteran+&rft.date=2019-01-14&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F59348%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F59348%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F59348%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Nikom+Sonia+Purohita%2C+1518011107++(2019)+PENGARUH+PEMBERIAN+MINUMAN+RINGAN+BERKARBONASI+TERHADAP+GAMBARAN+HISTOPATOLOGI+HEPAR+TIKUS+PUTIH+(Rattus+norvegicus)+JANTAN+GALUR+Sprague+dawley.++Fakultas+Kedokteran+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F59348%2F