?url_ver=Z39.88-2004&rft_id=1818011038&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+EKSTRAK+ETANOL+70+%25%0D%0ALIDAH+BUAYA+(Aloe+vera)+TERHADAP+PERBAIKAN++KERUSAKAN+SEL+HEPATOSIT+TIKUS+PUTIH+JANTAN+(Rattus+norvegicus)+%0D%0AGALUR+(Sparague+Dawley)+YANG+DIINDUKSI+ETANOL%0D%0A&rft.creator=Muhammad+Reivan+Putra+Athoriq%2C+1818011038&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+Belakang+%3A+Kegiatan+mengkonsumsi+alkohol+(etanol)+secara+kronik+mampu+meningkatkan+terjadinya+penyakit+hati+akibat+alkohol+dengan+meningkatkan+produksi+stress+oksidatif+pada+hepar+yang+mampu+merusak+fungsi+dan+struktur+hepar.+Antioksidan+yang+terkadung+dalam+lidah+buaya+(Aloe+vera)+dapat+meredam+produksi+radikal+bebas+akibat+hasil+metabolismenya+di+hepar.+Penelitian+ini+bertujuan+untuk+melihat+perbedaan+perbaikan+kerusakan+sel+hepatosit+tikus+putih+dengan+pemberian+ekstrak+lidah+buaya+(Aloe+vera)+yang+diinduksi+etanol%0D%0A%0D%0AMetode+%3A+Penelitian+ini+menggunakan+jenis+eksperimental+murni+dengan+rancangan+post-test+only+control+group+design%2C+dengan+hewan+uji+coba+sebagai+sampel+sebanyak+30+yang+terbagi+menjadi+5+kelompok%2C+kelompok+kontrol+negatif+(K1)+yang+diberikan+pakan+standar+dan+minum+aquades+ad+libidium%2C+kelompok+kontrol+positif+(K2)+yang+diberikan+perlakuan+etanol+40%25+dengan+dosis+1%2C8mL%2Fhari%2C+kelompok+perlakuan+(P1%2C+P2%2C+dan+P3)+yang+diberikan+perlakuan+etanol+40%25+peroral+dengan+dosis+1%2C8mL%2Fhari+kemudian+dilanjutkan+dengan+ekstrak+etanol+70%25+aloe+vera+dengan+dosis+bertingkat+200%2C+300+dan+400mg%2FKgBB%2Fhari+selama+14+hari.+Lalu+hepar+diambil+untuk+dilihat+dan+analisis+secara+mikroskopis%0D%0A%0D%0AHasil+%3A+Skoring+yang+didapatkan+pada+K1%3D0.16%2C+K2%3D2.6%2C+P1%3D1.84%2C+P2%3D1.76%2C+P3%3D1.28%2C+Kemudian+dianalisis+menggunakan+uji+Kruskal-Wallis+dan+dilanjutkan+dengan+uji+Mann+Whitney%2C+didapatkan+hasil+perbedaan+rerata+yang+bermakna+antara+kelompok+K2+dengan+P1%2C+P2%2C+dan+P3%0D%0A%0D%0AKesimpulan+%3A+Terdapat+perbedaan+perbaikan+kerusakan+sel+hepatosit+tikus+putih+dengan+pemberian+ekstrak+lidah+buaya+(Aloe+vera)+yang+diinduksi+oleh+etanol%0D%0A%0D%0AKata+Kunci+%3A+Aloe+Vera%2C+Antioksidan%2C+Hepatosit%0D%0A%0D%0A%0D%0ABackground%3A+Chronic+consumption+of+alcohol+(ethanol)+can+increase+the+occurrence+of+alcohol-induced+liver+disease+by+increasing+the+production+of+oxidative+stress+in+the+liver+which+can+damage+liver+function+and+structure.+Antioxidants+contained+in+Aloe+vera+can+reduce+the+production+of+free+radicals+due+to+their+metabolism+in+the+liver.+This+research+aims+to+determine+the+differences+in+the+repair+of+hepatocyte+cell+damage+in+white+rats+with+the+administration+of+aloe+vera+extract+induced+by+ethanol.%0D%0AMethods%3A+This+research+used+a+purely+experimental+methods+with+a+post-test+only+control+group+design%2C+with+a+sample+of+30+rats+devided+into+5+groups%2C+as+follow+negative+control+group+(K1)+given+standar+feed+and+aquadest%2C+positive+control+group+(K2)+given+40%25+ethanol+1%2C8mL%2Fday+peroral%2C+treatment+group+(P1%2CP2%2CP3)+given+40%25+ethanol+1%2C8mL%2Fday+peroral+followed+by+aloe+vera+extract+with+doses+200%2C+300%2C+and+400+mg%2Fday+peroral+for+14+days.+Then%2C+hepar+of+the+rat+is+taken+for+microscopic+examination.+%0D%0A%0D%0AResults%3A+The+scores+obtained+at+K1+%3D+0.16%2C+K2+%3D+2.6%2C+P1+%3D+1.84%2C+P2+%3D+1.76%2C+P3+%3D+1.28%2C+then+analyzed+using+the+Kruskal-Wallis+test+and+continued+with+the+Mann+Whitney+test%2C+the+results+obtained+significant+mean+differences+between+the+groups.+K2+with+P1%2C+P2%2C+and+P3%0D%0AConclusion+%3A+There+are+differences+in+the+repair+of+hepatocyte+cell+damage+in+white+rats+with+the+administration+of+aloe+vera+extract+induced+by+ethanol%0D%0AKeywords%3A+Aloe+Vera%2C+Antioxidant%2C+Hepatocytes%0D%0A&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2022-03-28&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F59791%2F1%2F1%252C%2520ABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F59791%2F2%2F2.%2520FILE%2520TUGAS%2520AKHIR%2520SKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F59791%2F3%2F3.%2520FILE%2520TUGAS%2520AKHIR%2520SKRIPSI%2520TANPA%2520PEMBAHASAN.pdf&rft.identifier=++Muhammad+Reivan+Putra+Athoriq%2C+1818011038++(2022)+PENGARUH+PEMBERIAN+EKSTRAK+ETANOL+70+%25+LIDAH+BUAYA+(Aloe+vera)+TERHADAP+PERBAIKAN+KERUSAKAN+SEL+HEPATOSIT+TIKUS+PUTIH+JANTAN+(Rattus+norvegicus)+GALUR+(Sparague+Dawley)+YANG+DIINDUKSI+ETANOL.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F59791%2F