<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
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<http://digilib.unila.ac.id/id/eprint/60446> <http://purl.org/dc/terms/title> "PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN SIRSAK (Annona\r\nmuricata Linn) TERHADAP GAMBARAN HISTOPATOLOGI GASTER\r\nTIKUS PUTIH (Rattus norvegicus) JANTAN GALUR Sprague dawley YANG\r\n\r\nDIINDUKSI METANIL YELLOW"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://digilib.unila.ac.id/id/eprint/60446> <http://purl.org/ontology/bibo/abstract> "Background : Methanil yellow can cause tissue damage through oxidative stress\r\nmechanism. Soursop leaves contain flavonoids which have antioxidant effects to\r\nprevent gastric mucosal damage. This study aimed to determine the effect of\r\ngiving circular leaf (Annona muricata Linn) ethanol extract on the\r\nhistopatological description of white rat gaster (Rattus norvegicus) male sprague\r\ndawley stain induced by methanil yellow.\r\n\r\nMethods : This study is a Post test Control Group Design pattern using 25 rats\r\nwhich were divided into 5 groups with treatment for 30 days. Group K- was given\r\n2 ml of distilled water. The K+ group was given methanyl yellow 3000\r\nmg/kgBW/day. Group P1 was given methanil yellow 3000 mg/kgBW/day and\r\nethanol extract of soursop leaves 100 mg/kgBW/day. Group P2 was given\r\nmethanil yellow 3000 mg/kgBW/day and ethanol extract of soursop leaves 200\r\nmg/kgBW/day. Group P3 was given methanil yellow 3000 mg/kgBW/day and\r\nethanol extract of soursop leaves 400 mg/kgBW/day. Observations were made\r\nusing a microscope by looking at the degree of gastric damage.\r\n\r\nResults : The results of the average degree of gastric damage of rats at K- =\r\n0.44±0.18 m; K+ = 1.8±2.5 m; P1 = 1.36±0.20 m; P2 = 1.08±0.18 m; and P3 =\r\n0.76±0.26 m. This study used the One Way ANOVA parametric test (p < 0.05)\r\nand continued with the Post Hoc LSD test (p < 0.05). There were significant\r\ndifferences in all groups.\r\nConclusions : There was an improvement in the administration of ethanolic\r\nextract of soursop (Annona muricata Linn) leaves to the gastric histopathological\r\npicture of male white rat (Rattus norvegicus) sprague dawley strain due to\r\nadministration of methanyl yellow.\r\nKeywords : Circular leaf, Gaster, Methanil Yellow\r\nLatar Belakang : Metanil yellow dapat menyebabkan kerusakan jaringan melalui\r\nmekanisme stress oksidatif. Daun sirsak memiliki kandungan flavonoid yang\r\nmemiliki efek antioksidan untuk menvcegah kerusakan mukosa lambung.\r\nPenelitian ini bertujuan untuk mengetahui adanya pengaruh pemberian ekstrak\r\netanol daun sirsak (Annona muricata Linn) terhadap gambaran histopatologi\r\ngaster tikus putih (Rattus norvegicus) jantan galur sprague dawley yang diinduksi\r\nmetanil yellow.\r\n\r\nMetode : Penelitian ini merupakan pola Post test Control Group Design\r\nmenggunakan 25 ekor tikus yang dibagi menjadi 5 kelompok dengan perlakuan\r\nselama 30 hari. Kelompok K- diberi aquades 2 ml. Kelompok K+ diberi metanil\r\nyellow 3000 mg/kgBB/hari. Kelompok P1 diberi metanil yellow 3000\r\nmg/kgBB/hari dan ekstrak etanol daun sirsak 100 mg/kgBB/hari. Kelompok P2\r\ndiberi metanil yellow 3000 mg/kgBB/hari dan ekstrak etanol daun sirsak 200\r\nmg/kgBB/hari. Kelompok P3 diberi metanil yellow 3000 mg/kgBB/hari dan\r\nekstrak etanol daun sirsak 400 mg/kgBB/hari. Pengamatan dilakukan\r\nmenggunakan mikroskop dengan melihat derajat kerusakan gaster.\r\n\r\nHasil : Hasil rerata derajat kerusakan gaster tikus pada K- = 0,44±0,18 μm; K+ =\r\n1,8±2,5 μm; P1 = 1,36±0,20 μm; P2 = 1,08±0,18 μm; dan P3 = 0,76±0,26 μm.\r\nPenelitian ini menggunakan uji parametrik One Way ANOVA (p<0,05) dan\r\ndilanjutkan uji Post Hoc LSD (p<0,05) didapatkan perbedaan yang bermakna pada\r\nsemua kelompok.\r\nKesimpulan : Terdapat perbaikan pemberian ekstrak etanol daun sirsak (Annona\r\nmuricata Linn) terhadap gambaran histopatologi gaster tikus putih (Rattus\r\nnorvegicus) jantan galur sprague dawley akibat pemberian metanil yellow.\r\nKata Kunci : Gaster, Metanil Yellow, Daun Sirsak"^^<http://www.w3.org/2001/XMLSchema#string> .
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