?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=IDENTIFIKASI+DAN+ISOLASI+SENYAWA+BIOAKTIF+ANTIOKSIDAN%0D%0ADARI+KULIT+BATANG+TUMBUHAN+TURI+PUTIH+(Sesbania+grandiflora%0D%0A(L.)+Pers.)+MENGGUNAKAN+PENDEKATAN+METABOLOMIK%0D%0A%0D%0ABERBASIS+LC-MS%2FMS&rft.creator=HABIBAH+MONANISA+RHESTIANI%2C+1617011098&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=White+turi+(S.+grandiflora)+is+one+of+native+Indonesian+plants+that+can+be+used+as+an%0D%0Aantioxidant.+The+aim+of+the+study+is+to+obtain+bioactive+antioxidant+compounds+isolated%0D%0Afrom+S.+grandiflora+through+metabolomic+approach+based+on+LC-MS%2FMS.+Isolations%0D%0Acompounds+obtained+through+extraction+method+with+three+variations+solvent%3A+75%25%0D%0AMeOH%3AEtOAc%2C+50%25+MeOH%3AEtOAc+l+and+25%25+MeOH%3AEtOAc+whereas+antioxidant+activity%0D%0Awas+tested+by+DPPH+method.+Highest+antioxidant+activity+obtained+on+25%25+MeOH%3AEtOAc%0D%0Aextract+with+IC50+values+of+40.52+%CE%BCg%2FmL.+The+result+of+LC-MS%2FMS+showed+92+known%0D%0Acompounds+and+183+unknown+compounds.+Steam+bark+extracks+can+be+grouped+based+on%0D%0Avariations+of+extracting+solvents+using+principal+component+analysis+(PCA)+with+a+total%0D%0Aprimary+component+(PC)+of+96%25.+LC-MS%2FMS+data+of+peak+area+were+correlated+with%0D%0Aantioxidant+activity+using+partial+least+square+(PLS).+The+result+of+PLS+showed+that%0D%0Acompound+A+(%CE%B1%2C+%CE%B1+%E2%80%93+trehalose)%2C+B+(Citric+acid)%2C+C+(Caffeic+acid)%2C+D+(Ferulic+acid)%2C+E%0D%0A(Azelaic+acid)%2C+F+(Unknown-82)%2CG+((6E)-7-(2H-1%2C3-benzodioxol-5-yl)-1-(piperidin-1-yl)%0D%0Ahept-6-en-1-one))%2C+H+(Unknown-159)%2C+I+(Unknown-166)%2C+J+(Unknown-178)+dan+K%0D%0A(Unknown-183)+is+a+metabolites+prediction+that+contributed+major+as+antioxidant+activity+to%0D%0Athe+white+turi+extract+and+provided+information+that+25%25+methanol+solvent+is+the+best%0D%0Aextracting+solvent+for+isolation+antioxidant+compounds.+The+Purified+compound+have+been%0D%0Asuccessfully+isolated+from+25+%25+MeOH%3AEtOAc+extract+through+several+steps+of%0D%0Afractionation+and+separation+using+Vacum+Liquid+Chromatography+(VLC)+and+Column%0D%0AChromatography+(CC)+repetitively.+The+isolated+compound+aquired+in+the+yellow+crystal%0D%0Asolid+as+much+2.2+mg+and+it+showed+the+antioxidant+activity+with+IC50+49.33+%CE%BCg%2FmL.%0D%0ACompound+identification+is+made+based+on+the+results+of+LC-MS%2FMS+data+analysis+and+TLC%0D%0Achromatogram+comparison+with+the+previous+isolated+compound.+The+isolated+compound%0D%0Ais+predicted+as+sesbagrandiflorain+B+atau+4-hydroxy-2-(4+%CC%81-hydroxy-2+%CC%81-%0D%0Ahydroxyphenyl)-6-methoxybenzofuran-3-carbaldehyde.%0D%0A%0D%0AKeywords%3A+S.+grandiflora%2C+metabolomic%2C+antioxidant%2C+LC-MS%2FMS%2C+PCA%2C+PLS%0D%0ATuri+putih+(S.+grandiflora)+merupakan+salah+satu+tumbuhan+asli+Indonesia+yang+dapat%0D%0Adimanfaatkan+sebagai+antioksidan.+Tujuan+penelitian+ini+adalah+mendapatkan+senyawa%0D%0Abioktif+antioksidan+dari+hasil+isolasi+yang+dilakukan+berdasarkan+pendekatan+metabolomik%0D%0Aberbasis+LC-MS%2FMS.+Senyawa+hasil+isolasi+didapatkan+melalui+metode+ekstraksi+dengan+3%0D%0Avariasi+konsentrasi+pelarut+MeOH%3AEtOAc+75%25%2C+50%25+dan+25%25%2C+sedangkan+aktivitas%0D%0Aantioksidan+ekstrak+diuji+dengan+metode+DPPH.+Aktivitas+antioksidan+paling+baik%0D%0Adiperoleh+dari+ekstrak+MeOH%3AEtOAc+25%25+dengan+nilai+IC50+sebesar+40%2C52+%CE%BCg%2FmL.+Dari%0D%0Ahasil+analisis+LC-MS%2FMS+92+senyawa+known+dan+183+senyawa+unknown.+Ekstrak+sampel%0D%0Akulit+batang+turi+dapat+dikelompokan+berdasarkan+perbedaan+pelarut+pengekstrak+melalui%0D%0Aanalisis+principal+component+analysis+(PCA)+dengan+total+primary+component+(PC)+96%25.%0D%0AData+LC-MS%2FMS+yang+berupa+luas+puncak+dikorelasikan+dengan+aktivitas+antioksidan%0D%0Amenggunakan+partial+least+square+(PLS).+Hasil+analisis+PLS+menunjukkan+bahwa+senyawa%0D%0AA+(%CE%B1%2C+%CE%B1+%E2%80%93+trehalose)%2C+B+(Citric+acid)%2C+C+(Caffeic+acid)%2C+D+(Ferulic+acid)%2C+E+(Azelaic+acid)%2C%0D%0AF+(Unknown-82)%2CG+((6E)-7-(2H-1%2C3-benzodioxol-5-yl)-1-(piperidin-1-yl)+hept-6-en-1-%0D%0Aone))%2C+H+(Unknown-159)%2C+I+(Unknown-166)%2C+J+(Unknown-178)+dan+K+(Unknown-183)%0D%0Amerupakan+senyawa+atau+metabolit+penciri+yang+diprediksi+berkontribusi+major+(utama)%0D%0Apada+aktivitas+antioksidan+ekstrak+kulit+batang+turi+putih%2C+serta+memberikan+informasi%0D%0Abahwa+pelarut+MeOH%3AEtOAc+25%25+merupakan+pelarut+pengekstrak+antioksidan+terbaik%0D%0Auntuk+isolasi+senyawa.+Senyawa+murni+berhasil+diisolasi+dari+ekstrak+MeOH%3AEtOAc%0D%0A25%25+melalui+beberapa+tahapan+pemisahan+dan+pemurnian+dengan+teknik%0D%0Akromatografi+cair+vakum+(KCV)+dan+kromatografi+kolom+grafitasi+(KKG)+secara%0D%0Aberulang.+Isolat+yang+diperoleh+berupa+kristal+kuning+sebanyak+2%2C2+mg+dan%0D%0Amenunjukkan+aktivitas+antioksidan+dengan+nilai+IC50+49%2C33+%CE%BCg%2FmL.+Identifikasi%0D%0Asenyawa+dilakukan+berdasarkan+hasil+analisis+data+LC-MS%2FMS+dan+perbandingan%0D%0Akromatogram+KLT+dengan+senyawa+hasil+isolasi+sebelumnya.+Senyawa+hasil+isolasi%0D%0Adiprediksi+sebagai+sesbagrandiflorain+B+atau+4-hydroxy-2-(4+%CC%81-hydroxy-2+%CC%81-%0D%0Ahydroxyphenyl)-6-methoxybenzofuran-3-carbaldehyde.%0D%0AKata+kunci%3A+S.+grandiflora%2C+metabolomik%2C+antioksidan%2C+LC-MS%2FMS%2C+PCA%2C+PLS.&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2021&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F60787%2F1%2FABSTRAK%2520-%2520Habibah%2520Monanisa.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F60787%2F2%2FSKRIPSI%2520FULL%2520-%2520Habibah%2520Monanisa.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F60787%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN%2520-%2520Habibah%2520Monanisa.pdf&rft.identifier=++HABIBAH+MONANISA+RHESTIANI%2C+1617011098++(2021)+IDENTIFIKASI+DAN+ISOLASI+SENYAWA+BIOAKTIF+ANTIOKSIDAN+DARI+KULIT+BATANG+TUMBUHAN+TURI+PUTIH+(Sesbania+grandiflora+(L.)+Pers.)+MENGGUNAKAN+PENDEKATAN+METABOLOMIK+BERBASIS+LC-MS%2FMS.++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F60787%2F