@misc{eprints60923,
           month = {Desember},
           title = {KAJIAN PEMBERIAN BERAS SIGER DARI KLON UBI KAYU WAXY
TERHADAP GAMBARAN HISTOPATOLOGI KELENJAR MAMMAE
DAN PROFIL KIMIA DARAH MENCIT YANG DIINDUKSI

7,12-DIMETHYLBENZ(?)ANTHRACENE},
          author = {1714051021 ADINDA AYU LARASATI},
         address = {UNIVERSITAS LAMPUNG},
       publisher = {Fakultas Pertanian},
            year = {2021},
             url = {http://digilib.unila.ac.id/60923/},
        abstract = {Kanker payudara merupakan salah satu jenis penyakit mematikan yang umumnya
diderita oleh wanita di seluruh dunia. Pengobatan kemoterapi memberikan efek
samping dengan merusak sel sehat penderita. Beras siger dari klon ubi kayu waxy
diharapkan dapat menjadi alternatif pengobatan bagi penderita kanker payudara.
Penelitian ini bertujuan untuk mengetahui pengaruh pemberian beras siger dari
klon ubi kayu waxy terhadap gambaran histopatologi kelenjar mammae dan profil
kimia darah mencit yang diinduksi 7,12-dimethylbenz({\ensuremath{\alpha}})anthracene (DMBA).
Perlakuan disusun dalam Rancangan Acak Lengkap (RAL) dengan 6 ulangan dan
4 perlakuan, yaitu K- (kontrol + ransum standar), K+ (DMBA + ransum standar),
BS (DMBA + ransum beras siger), dan BP (DMBA + ransum beras IR-64).
Pengamatan dilakukan pada gambaran histopatologi kelenjar mammae dan profil
kimia darah meliputi jumlah eritrosit, leukosit, hemoglobin, dan hematokrit. Data
yang dihasilkan dianalisis untuk uji homogenitas dan aditivitas dengan uji Barlett
dan Tuckey, kemudian dilanjutkan dengan ANOVA dan uji lanjut BNT taraf 5\%.
Hasil penelitian menunjukkan bahwa pemberian beras siger dari klon ubi kayu
waxy pada mencit yang diinduksi DMBA menyebabkan penurunan derajat
diferensiasi (grade) menjadi diferensiasi baik (grade 1) dengan gambaran
histopatologi sel kanker mirip dengan jaringan payudara normal, jumlah eritrosit
(5,38 juta/mm3

), leukosit (4,00 ribu/mm3

), hemoglobin (9,25 g/dL) dan hematokrit

(30 \%).

Kata kunci: kanker payudara, beras siger, mencit, DMBA, histopatologi, profil

kimia darah.

Breast cancer is one of the most common types of deadly disease suffered by
women worldwide. Chemotherapy treatment has side effects by damaging the
patient's healthy cells. Siger rice from waxy cassava clone is expected to be an
alternative treatment for breast cancer patients. This study aimed to determine the
effect of giving siger rice from waxy cassava clones on the histopathology of
mammary gland and blood chemical profiles in DMBA-induced mice. The
treatments were arranged in a Completely Randomized Design (CRD) with 6
replications and 4 treatments, there are K- (control + standard feed), K+ (DMBA
+ standard feed), BS (DMBA + siger rice feed), and BP (DMBA + IR-64 rice
feed). Observation were made on histopathological description of mammary
gland and blood chemical profile including the number of erythrocytes,
leukocytes, hemoglobin, and hematocrit. The data were analyzed for homogenity
and additivity using the Barlett and the Tuckey test, then continued with the
ANOVA and a 5\% level of LSD test. The results showed that the administration
of siger rice from waxy cassava clones to DMBA-induced mice caused a decrease
in the degree of differentiation (grade) to well differentiated (grade 1) with the
histopathological appearance of cancer cells similar to normal breast tissue, as
well as a decrease in the number of erythrocytes (5,38 million/mm3), leukocytes
(4,00 thousand/mm3), hemoglobin (9,25 g/dL) and hematocrit (30\%).

Keyword: breast cancer, siger rice, mice, DMBA, histopathology, blood chemical

profile.}
}