?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+EKSTRAK+BAWANG+PUTIH+(Allium+sativum+L.)%0D%0ATERHADAP+GAMBARAN+HISTOLOGI+PARU-PARU+MENCIT+YANG%0D%0A%0D%0ATERPAPAR+ASAP+ROKOK&rft.creator=Maryeta+Handayani+Sitepu%2C+1717021073&rft.subject=570+Biologi&rft.description=ABSTRAK%0D%0A%0D%0APengaruh+Ekstrak+Bawang+Putih+(Allium+sativum+L.)+Terhadap+Gambaran%0D%0AHistologi+Paru-Paru+Mencit+Yang+Terpapar+Asap+Rokok%0D%0A%0D%0AOleh%0D%0A%0D%0AMaryeta+Handayani+Sitepu%0D%0A%0D%0AAsap+rokok+merupakan+sumber+radikal+bebas+yang+menimbulkan+stress+oksidatif%0D%0Ayang+menyebabkan+respon+inflamasi+dan+kerusakan+paru.+Radikal+bebas+di+dalam%0D%0Atubuh+dapat+dihambat+oleh+antioksidan+untuk+menurunkan+resiko+kerusakan%0D%0Ajaringan+paru-paru.+Bawang+putih+memiliki+kandungan+senyawa+yang+efektif%0D%0Asebagai+antioksidan+untuk+mencegah+kerusakan+paru-paru.+Penelitian+ini+bertujuan%0D%0Auntuk+mengetahui+pengaruh+ekstrak+bawang+putih+(Allium+sativum+L.)+terhadap%0D%0Agambaran+histologi+paru-paru+mencit+yang+terpapar+asap+rokok.+Penelitian%0D%0Aeksperimental+ini+menggunakan+mencit+(Mus+musculus)+jantan+yang+berumur+5%0D%0Aminggu+sebanyak+30+ekor+yang+dibagi+secara+acak+menjadi+3+perlakuan+yaitu+K0%0D%0Asebagai+kontrol+positif%2C+K1+sebagai+kontrol+negatif%2C+P1+diberi+paparan+asap+rokok%0D%0Adan+ekstrak+bawang+putih+dengan+dosis+1000+mg%2FkgBB+per+hari+di+sore+hari+dan%0D%0Adilakukan+selama+35+hari.+Sumber+radikal+bebas+diperoleh+secara+asap+samping%0D%0A(sidestream+smoke)+selama+15+menit%2Fhari+dilakukan+setiap+pagi.+Pada+hari+ke-36%2C%0D%0Amencit+dibedah+dan+dilakukan+pembuatan+preparat.+Derajat+kerusakan+jaringan+paru%0D%0Amencit+dinilai+menggunakan+skoring+destruksi+septum+alveolar+dan+infiltrasi+sel%0D%0Aradang.+Semua+data+diuji+secara+statistik+menggunakan+Kruskall+wallis+dan+Post%0D%0AHoc+Mann+Whitney.+Hasil+penelitian+menunjukkan+bahwa+bawang+putih+dengan%0D%0Adosis+1000+mg%2FkgBB+dapat+mengurangi+terjadinya+kerusakan+pada+paru-paru%0D%0Amencit+yang+diberi+paparan+asap+rokok+selama+35+hari.%0D%0A%0D%0AKata+kunci%3A+Cigarette+smoke%2C+free+radicals%2C+antioxidants%2C+garlic+extract%2C+lung%0D%0A%0D%0Ahistology.%0D%0A%0D%0Aiii%0D%0A%0D%0AABSTRACT%0D%0A%0D%0AEffect+of+Garlic+Extract+(Allium+sativum+L.)+on+Lung+Histology+of+Mice%0D%0A%0D%0AExposed+to+Cigarette+Smoke%0D%0A%0D%0ABy%0D%0A%0D%0AMaryeta+Handayani+Sitepu%0D%0A%0D%0ACigarette+smoke+is+a+source+of+free+radicals+that+cause+oxidative+stress+that+causes%0D%0Aan+inflammatory+response+and+lung+damage.+Free+radicals+in+the+body+can+be%0D%0Ainhibited+by+antioxidants+to+reduce+the+risk+of+lung+tissue+damage.+Garlic+contains%0D%0Acompounds+that+are+effective+as+antioxidants+to+prevent+lung+damage.+This+study%0D%0Aaims+to+determine+the+effect+of+garlic+extract+(Allium+sativum+L.)+on+the+histological%0D%0Apicture+of+the+lungs+of+mice+exposed+to+cigarette+smoke.+This+experimental+study%0D%0Aused+30+male+mice+(Mus+musculus)+aged+5+weeks+which+were+divided+randomly%0D%0Ainto+3+treatments%2C+namely+K0+as+positive+control%2C+K1+as+negative+control%2C+P1+exposed%0D%0Ato+cigarette+smoke+and+garlic+extract+at+a+dose+of+1000+mg%2FkgBW.+per+day+in+the%0D%0Aafternoon+and+carried+out+for+35+days.+Sources+of+free+radicals+are+obtained+by%0D%0Asidestream+smoke+for+15+minutes%2Fday+every+morning.+On+the+36th+day%2C+the+mice%0D%0Awere+dissected+and+preparations+were+made.+The+degree+of+damage+to+lung+tissue+in%0D%0Amice+was+assessed+using+the+scoring+of+alveolar+septal+destruction+and+inflammatory%0D%0Acell+infiltration.+All+data+were+statistically+tested+using+Kruskall+Wallis+and+Post%0D%0AHoc+Mann+Whitney.+The+results+showed+that+garlic+with+a+dose+of+1000+mg%2FkgBW%0D%0Acould+reduce+the+occurrence+of+damage+to+the+lungs+of+mice+exposed+to+cigarette%0D%0Asmoke+for+35+days.%0D%0A%0D%0AKeywords%3A+Cigarette+smoke%2C+free+radicals%2C+antioxidants%2C+garlic+extract%2C+lung%0D%0A%0D%0Ahistology.&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2021&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F61082%2F1%2F1.%2520ABSTRAK%2520-%2520MARYATI.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F61082%2F2%2F2.%2520SKRIPSI%2520FULL%2520-MARYATI.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F61082%2F3%2F3.%2520SKRIPSI%2520FULL%2520TANPA%2520BAB%2520PEMBAHASAN%2520-%2520MARYATI.pdf&rft.identifier=++Maryeta+Handayani+Sitepu%2C+1717021073++(2021)+PENGARUH+EKSTRAK+BAWANG+PUTIH+(Allium+sativum+L.)+TERHADAP+GAMBARAN+HISTOLOGI+PARU-PARU+MENCIT+YANG+TERPAPAR+ASAP+ROKOK.++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F61082%2F