?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PEMBERIAN+EKSTRAK+BELIMBING+WULUH+(Averrhoa%0D%0Abilimbi+L.)+UNTUK+PENILAIAN+KERUSAKAN+ARTERI%0D%0AKORONARIA+TIKUS+PUTIH+(Rattus+novergicus)+GALUR%0D%0AWISTAR+YANG+DIINDUKSI+MINYAK+JELANTAH&rft.creator=DEVI+MEIDAYANTI%2C+1718011042&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Background%3A+Free+radical+contained+in+the+used+cooking+oil+is+known+to+cause+the%0D%0Acoronary+artery.+Star+fruit+(Averrhoa+bilimbi+L.)+contains+many+antioxidant+such%0D%0Aflavonoid%2C+tanin%2C+and+saponin+which+known+to+reduce+coronary+artery+damage+due%0D%0Ato+the+used+cooking+oil.%0D%0AObjectives%3A+To+determine+the+effect+of+star+fruit+extract+(Averrhoa+bilimbi+L.)+on%0D%0Athe+coronary+artery+histopathology+of+Wistar+white+rats+induced+by+used+cooking%0D%0Aoil.%0D%0AMethods%3A+Laboratory+experimental+research+with+a+Post+Test-Only+Control+Group%0D%0ADesign+pattern.+Research+using+25+rats+which+divided+into+5+groups%2C+namely+K1%0D%0A(aquades)%2C+K2+(used+cooking+oil)%2C+P1%2C+P2%2C+P3+given+used+cooking+oil+at+a+dose+of%0D%0A1%2C5+mL+and+extract+with+different+doses+(80+mg%2C+160+mg%2C+and+320+mg)+for+28+days.%0D%0AResults%3A+The+results+showed+that+the+mean+of+coronary+artery+lumen+diameter+of%0D%0Athe+rats+are+K1%3D121%2C27+%CE%BCm%3B+K2%3D64%2C55+%CE%BCm%3B+P1%3D81%2C79+%CE%BCm%3B+P2%3D98%2C34+%CE%BCm%3B%0D%0AP3%3D12%2C27+%CE%BCm.+Statistical+analysis+using+One+Way+ANOVA+parametric+test%0D%0A(p%3C0%2C05)+followed+by+the+Post-hoc+LSD+test+(p%3C0%2C05)+showed%2C+that+there+are%0D%0Asignificant+differences+in+most+groups%2C+except+for+P1+with+P2+groups.%0D%0AConclusion%3A+There+is+an+effect+of+extract+of+Averrhoa+bilimbi+L.+administration%0D%0Aon+the+coronary+artery+histopathology+of+albino+rats+(Rattus+novergicus)+Wistar%0D%0Astrain+induced+by+used+cooking+oil.%0D%0A%0D%0AKeywords+%3A+Star+fruit+(Averrhoa+bilimbi+L.)%2C+Coronary+Artery%2C+used+cooking+oil%0D%0A%0D%0ALatar+Belakang%3A+Penggunaan+minyak+jelantah+dapat+menyebabkan+kerusakan%0D%0Apada+arteri+koronaria+karena+mengandung+radikal+bebas.+Ekstrak+etanol+96%25+buah%0D%0ABelimbing+wuluh+(Averrhoa+bilimbi+L.)+mengandung+flavonoid%2C+tanin%2C+dan%0D%0Asaponin+yang+berfungsi+sebagai+antioksidan+dalam+mengurangi+kerusakan+arteri%0D%0Akoronaria+akibat+minyak+jelantah.%0D%0ATujuan%3A+Untuk+mengetahui+pengaruh+pemberian+ekstrak+belimbing+wuluh%0D%0A(Averrhoa+bilimbi+L.)+terhadap+gambaran+arteri+koronaria+tikus+putih+jantan+glur%0D%0AWistar+yang+diinduksi+minyak+jelantah.%0D%0AMetode%3A+Penelitian+ini+berdesain+eksperimental+laboratorium+dengan+pola+Post%0D%0ATest-Only+Control+Group+Design.+Jumlah+sampel+25+ekor+dibagi+menjadi+5%0D%0Akelompok%2C+yaitu+K1+(akuades)%2C+K2+(minyak+jelantah+1%2C5+mL)%2C+P1%2C+P2%2C+P3+diberikan%0D%0Aminyak+jelantah+dengan+dosis+1%2C5+mL+dan+ekstrak+belimbing+wuluh+dengan+dosis%0D%0Ayang+berbeda+(80+mg%2C+160+mg%2C+dan+320+mg%2F200gr+BB)+selama+28+hari.%0D%0AHasil%3A+Hasil+rerata+pengukuran+diameter+lumen+arteri+koronaria+tikus+pada%0D%0AK1%3D121%2C27+%CE%BCm%3B+K2%3D64%2C55+%CE%BCm%3B+P1%3D81%2C79+%CE%BCm%3B+P2%3D98%2C34+%CE%BCm%3B+P3%3D12%2C27+%CE%BCm.%0D%0APenelitian+ini+menggunakan+uji+parametrik+One+Way+ANOVA+(p%3C0%2C05)%2C%0D%0Adilanjutkan+uji+Post-hoc+LSD+(p%3C0%2C05).+Didapatkan+perbedaan+yang+bermakna%0D%0Apada+sebagian+besar+kelompok%2C+kecuali+kelompok+P1+dengan+P2.%0D%0ASimpulan%3A+Terdapat+pengaruh+ekstrak+buah+belimbing+wuluh+(Averrhoa+bilimbi%0D%0AL.)+terhadap+gambaran+perbaikan+kerusakan+arteri+koronaria+tikus+putih+jantan%0D%0A(Rattus+novergicus)+galur+Wistar+yang+diinduksi+minyak+jelantah.%0D%0A%0D%0AKata+kunci%3A+Belimbing+Wuluh%2C+Arteri+Koronaria%2C+minyak+jelantah&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2021&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F61278%2F2%2F1.%2520ABSTRAK%2520-%2520DEVI.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F61278%2F3%2F2.%2520SKRIPSI%2520FULL%2520-%2520DEVI.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F61278%2F1%2F3.%2520SKRIPSI%2520FULL%2520TANPA%2520BAB%2520PEMBAHASAN%2520-DEVI.pdf&rft.identifier=++DEVI+MEIDAYANTI%2C+1718011042++(2021)+PEMBERIAN+EKSTRAK+BELIMBING+WULUH+(Averrhoa+bilimbi+L.)+UNTUK+PENILAIAN+KERUSAKAN+ARTERI+KORONARIA+TIKUS+PUTIH+(Rattus+novergicus)+GALUR+WISTAR+YANG+DIINDUKSI+MINYAK+JELANTAH.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F61278%2F