?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Uji+Efektifitas+Ekstrak+Batang+Bratawali+(Tinospora+Cordifolia)+pada%0D%0APerubahan+Gambaran+Histopatologis+Paru+pada+Tikus+Putih+Jantan%0D%0A%0D%0Ayang+Diinduksi+Asap+Rokok&rft.creator=James+Abel+Pangihutan%2C+1718011087&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+Belakang%3A+Kebiasaan+Merokok+merupakan+salah+satu+faktor+yang+menjadi+penyebab%0D%0Amasalah+penyakit+di+dunia.+Sebanyak+1.3+miliar+orang+di+dunia+merupakan+perokok+dengan%0D%0A25%25+dari+populasi+wanita+merupakan+perokok+dan+50%25+dari+populasi+pria+adalah+perokok.%0D%0APerilaku+merokok+yang+kronik+menyebabkan+berbagai+masalah+kesehatan+terutama+pada+organ%0D%0Aparu+yang+terkena+paparan+langsung+dari+asap+rokok.+Paparan+asap+rokok+dapat+menyebabkan%0D%0Akerusakan+paru+berupa+inflamasi+pada+jaringan+paru+bila+terpapar+secara+akut+dan+bisa+berlanjut%0D%0Amenjadi+penyakit+paru+obstruktif+maupun+kanker+paru+pada+paparan+jangka+panjang.+Batang%0D%0A%0D%0ABratawali+(Tinospora+Cordifolia)+memiliki+senyawa+dengan+efek+anti-inflamasi+dan+anti-%0D%0Aoksidan+yang+dapat+mengurangi+efek+inflamasi+dari+paparan+asap+rokok.+Penelitian+ini+bertujuan%0D%0A%0D%0Auntuk+mengetahui+efek+dari+ekstrak+batang+bratawali+terhadap+perubahan+gambaran+jaringan%0D%0Aparu.%0D%0AMetode%3A+Penelitian+ini+menggunakan+desain+penelitian+posttest+only+control+group+design%0D%0Adengan+menguji+aktivitas+anti-inflamasi+ekstrak+batang+bratawali+dengan+dosis+sebanyak%0D%0A150mg%2Fkg%2C+200mg%2Fkg%2C+dan+250mg%2Fkg+pada+tikus+putih+jantang+yang+telah+dipaparkan+asap%0D%0Arokok+selama+10+menit.+Hasil+penelitian+dinilai+menggunakan+skoring+kerusakan+paru+yang%0D%0Aterdiri+dari+jumlah+infiltrasi+neutrofil+pada+alveolus+dan+jaringan+interstitial+serta+pembentukan%0D%0Amembran+hialin.%0D%0AHasil%3A+Hasil+dari+penelitian+ini+didapatkan+rerata+skoring+setiap+kelompok+berupa+0.0513%2C%0D%0A0.035%2C+0.037%2C+0.0277%3B+untuk+kelompok+K%2C+P1%2C+P2%2C+dan+P3+secara+berurutan.+Pengolahan+data%0D%0Akruskal+wallis+didapatkan+p+sebesar+0.226+(p%3E0.05)%2C+sehingga+perbedaan+hasil+setiap+kelompok%0D%0Adidapatkan+tidak+signifikan.%0D%0AKesimpulan%3A+Kesimpulan+penelitian+ini%2C+didapatkan+bahwa+pemberian+ekstrak+batang%0D%0Abratawali+pada+tikus+putih+yang+dipaparkan+asap+rokok+tidak+ditemukan+adanya+perubahan%0D%0Agambaran+histopatologis+yang+signifikan.%0D%0ABackground%3A+Smoking+is+one+of+the+biggest+factor+which+can+cause+health+problems+in+the%0D%0Aworld.+As+much+as+about+1.3+billion+people+in+the+world+smoke+cigarretes%2C+in+which+25%25+of+the%0D%0Afemales+and+50%25+of+the+males+are+cigarettes+smoker.+A+chronic+smoking+habits+can+cause%0D%0Amyriad+health+problems%2C+primarly+to+the+lung+which+are+directly+exposed+to+the+smoke.%0D%0ACigarrete+smoke+exposure+can+cause+acute+inflammation+to+the+lung%E2%80%99s+tissues+and+can+develop%0D%0Ainto+chronic+obstructive+pulmonary+disease+or+lung+cancer+in+the+long+run.+Tinospora+Cordifola%0D%0Ahas+anti-inflammation+and+antioxidant+properties+which+can+protect+the+lung+from+acute%0D%0Ainflammations.+The+aim+of+this+study+was+to+examine+the+anti-inflammation+effect+of+the%0D%0ATinospora+Cordifolia+extracts+to+the+histopathological+changes+of+the+lung%E2%80%99s+tissues.%0D%0AMethods%3A+This+study+used+the+posttest+only+control+group+design+method.+The+study+measured%0D%0Aan+antiinflammation+activity+of+Tinospora+Cordifolia+with+the+dosage+of+150mg%2Fkg%2C+200mg%2Fkg%2C%0D%0Aand+250+mg%2Fkg+on+white+male+mice+exposed+to+cigarettes%E2%80%99+smoke+for+10+minutes.+The+result%0D%0Awas+measured+using+lung+damage+scoring.+The+scoring+assesses+the+lung+damage+based+on+the%0D%0Ainfiltration+of+neutrofil+in+alveolus+and+interstitial+and+the+forming+of+hyalin+membrane.%0D%0AResults%3A+The+result+of+this+study+is+the+mean+scoring+of+each+group+are+0.0513%2C+0.035%2C+0.037%2C%0D%0A0.0277%3B+for+the+group+K%2C+P1%2C+P2%2C+and+P3+respectively.+P+value+is+0.0226+(p%3E0.05)%2C+which+means%0D%0Athere+are+no+significant+differences+of+results+in+each+group.%0D%0AConclusion%3A+From+the+study%2C+we+found+that+the+application+of+Tinospora+Cornifolia+stem%0D%0Aextraction+to+white+mice+exposed+to+cigarettes%E2%80%99+smoke+doesn%E2%80%99t+result+in+significant+differences%0D%0Ain+histopathological+changes+of+it%E2%80%99s+lung.&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2021&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F61505%2F2%2F1.%2520ABSTRAK%2520-%2520ALLIF%2520PRINTING.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F61505%2F3%2F2.%2520SKRIPSI%2520FULL%2520-%2520ALLIF%2520PRINTING.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F61505%2F4%2F3.%2520SKRIPSI%2520FULL%2520TANPA%2520BAB%2520PEMBAHASAN%2520-%2520ALLIF%2520PRINTING.pdf&rft.identifier=++James+Abel+Pangihutan%2C+1718011087++(2021)+Uji+Efektifitas+Ekstrak+Batang+Bratawali+(Tinospora+Cordifolia)+pada+Perubahan+Gambaran+Histopatologis+Paru+pada+Tikus+Putih+Jantan+yang+Diinduksi+Asap+Rokok.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F61505%2F