?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PEMBUATAN+MIKROKOMPOSIT+HIDROGEL+%0D%0ABERBAHAN+DASAR+LIMBAH+ONGGOK+SINGKONG++%0D%0ADARI+RESIDU+FRAKSI+SELULOSA+%0D%0A&rft.creator=RENNY+ANDRELIA+ANTIKA%2C+1717011027&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=+%0D%0A%0D%0A%0D%0A%0D%0A%0D%0A+%0D%0AABSTRAK%0D%0A%0D%0A%0D%0A+%0D%0A%0D%0AObat+dengan+kemampuan+penghantaran+yang+tepat+diperoleh+dengan+adanya%0D%0Asistem+penghantaran+obat.+Mikrokomposit+selulosa+limbah+onggok+singkong%0D%0Adalam+bentuk+hidrogel+memiliki+kemampuan+penghantaran+obat+yang+baik.+Pada%0D%0Apenelitian+ini+dilakukan+pemisahan+amilum+pada+limbah+onggok+singkong+untuk%0D%0Amendapatkan+residu+berupa+selulosa.+Selulosa+kemudian+dihidrolisis%0D%0Amenggunakan+H%0D%0A2%0D%0ASO%0D%0A4%0D%0A+encer+dan+dilakukan+sonikasi+untuk+mendapatkan+partikel%0D%0Aselulosa+berukuran+mikro.+Mikroselulosa+yang+dihasilkan+diolah+menjadi+hidrogel%0D%0Adengan+metode+taut+silang+antara+akriamida+dan+metilen-bis-akrilamida.+Hidrogel%0D%0Adikarakterisasi+menggunakan+scanning+electron+microscopy+(SEM)+dan+fourier%0D%0Atransform+infrared+spectroscopy+(+FTIR).+Penelitian+ini+berhasil+dengan+diperoleh+%0D%0Amikrokristalin+berukuran+1%2C190+%EF%81%ADm.+Hidrogel+memiliki+kemampuan+mengembang%0D%0A18+kali.+Analisis+FTIR+menunjukkan+beberapa+daerah+serapan+pada+1654+cm%0D%0A-1%0D%0A%0D%0Amenunjukkan+pembacaan+gugus+C%3DO+dan+3190+cm%0D%0A-1%0D%0A+menandakan+pembacaan+%0D%0AN-H+yang+menunjukkan+bahwa+proses+pengikatan+silang+berhasil.+Penggunaan+%0D%0Aamoksisilin+konsentrasi+600+%EF%81%ADg%2FmL+dalam+pemuatan+bahan+mikrokomposit%0D%0Ahidrogel+yang+diperoleh+mampu+menghambat+pertumbuhan+Escherichia+coli+dan%0D%0AStaphylococcus+aureus.+Penelitian+ini+menunjukkan+potensi+limbah+singkong%0D%0Asebagai+bahan+yang+dapat+dimanfaatkan+untuk+bahan+baku+obat.%0D%0A%0D%0A%0D%0AKata+Kunci%3A+Sistem+Penghantar+Obat%2C+Limbah+Singkong%2C+Mikroselulose%2C+Hidrogel%0D%0A%0D%0A+%0D%0A+%0D%0A%0D%0ADrugs+with+proper+delivery+capability+are+obtained+by+means+of+a+drug+delivery%0D%0Asystem.+Cassava+waste+cellulose+microcomposite+in+the+form+of+hydrogel+has+good%0D%0Adrug+delivery+ability.+In+this+research%2C+starch+was+separated+from+cassava+waste+to%0D%0Aobtain+a+residue+in+the+form+of+cellulose.+Cellulose+was+then+hydrolyzed+using%0D%0Adilute+H%0D%0A2%0D%0ASO%0D%0A4%0D%0A+and+sonicated+to+obtain+micro-sized+cellulose+particles.+The+resulting%0D%0Amicrocellulose+was+processed+into+hydrogel+by+cross-linking+method+between%0D%0Aacrylamide+and+methylene-bis-acrylamide.+Hydrogels+were+characterized+using%0D%0Ascanning+electron+microscopy+(SEM)+and+Fourier+transform+infrared+spectroscopy%0D%0A(FTIR).+This+research+was+successful+by+obtaining+microcrystals+measuring+1%2C190+%0D%0A%EF%81%ADm.+The+hydrogel+has+the+ability+to+expand+18+times.+FTIR+analysis+showed%0D%0Aseveral+absorption+regions+at+1654+cm%0D%0A-1%0D%0A+indicating+a+reading+of+the+C%3DO+group+and%0D%0A3190+cm%0D%0A-1%0D%0A+indicating+an+N-H+reading+indicating+that+the+crosslinking+process+was%0D%0Asuccessful.+The+use+of+amoxicillin+concentration+of+600+%EF%81%ADg%2FmL+in+loading+%0D%0Ahydrogel+microcomposite+material+that+can+inhibit+the+growth+of+Escherichia+coli%0D%0Aand+Staphylococcus+aureus.+This+research+shows+the+potential+of+cassava+waste+as%0D%0Aa+material+that+can+be+used+for+medicinal+raw+materials.%0D%0A%0D%0A%0D%0AKeywords%3A+Drug+Delivery+System%2C+Cassava+Waste%2C+Microcellulose%2C+Hydrogel++%0D%0A%0D%0A++&rft.publisher=FAKULTAS+MIPA&rft.date=2021&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F62016%2F3%2F1.%2520ABSTRAK-RENNY.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F62016%2F1%2F2.%2520SKRIPSI%2520FULL%2520-%2520RENNY.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F62016%2F2%2F3.%2520SKRIPSI%2520TANPA%2520RENNY.pdf&rft.identifier=++RENNY+ANDRELIA+ANTIKA%2C+1717011027++(2021)+PEMBUATAN+MIKROKOMPOSIT+HIDROGEL+BERBAHAN+DASAR+LIMBAH+ONGGOK+SINGKONG+DARI+RESIDU+FRAKSI+SELULOSA.++FAKULTAS+MIPA%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F62016%2F