?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=EFEK+PEMBERIAN+EKSTRAK+ETANOL+95%25+DAUN+(Rhizophora+apiculata)+TERHADAP+GAMBARAN+MIKROSKOPIS+ARTERI+KORONARIA+TIKUS++%0D%0APUTIH+JANTAN+(Rattus+norvegicus)+YANG++DIINDUKSI+DIET+TINGGI+LEMAK+&rft.creator=++INTAN++FITRIYANA+%2C+1858011052&rft.subject=000+Ilmu+komputer%2C+informasi+dan+pekerjaan+umum&rft.subject=030+Karya+ensiklopedia+umum&rft.description=+%0D%0A+%0D%0AABSTRAK+%0D%0AEFEK+PEMBERIAN+EKSTRAK+ETANOL+95%25++DAUN+(Rhizophora+apiculata)+TERHADAP+GAMBARAN+MIKROSKOPIS+%0D%0AARTERI+KORONARIA+TIKUS+PUTIH+JANTAN+(Rattus+norvegicus)+YANG+DIINDUKSI+DIET+TINGGI+LEMAK+%0D%0A+Oleh++%0D%0A+INTAN+FITRIYANA+%0D%0A+++%0D%0ALatar+Belakang%3A+Aterosklerosis+merupakan+suatu+penyakit+disebabkan+oleh+proses+inflamasi+yang+disertai+dengan+adanya+penimbunan+pada+lipid+didinding+arteri.+Penyebab+umum+dari+aterosklerosis+adalah+dislipidemia.+Daun+(Rhizophora+apiculata)+mengandung+alkaloid%2C+flavonoid%2C+triterpenoid%2C+steroid%2C+saponin+dan+tannin+yang+berfungsi+sebagai+antidislipidemia+dan+antioksidan.+Tujuan+penelitian+ini+untuk+mengetahui+efek+ekstrak+etanol+95%25+daun+(Rhizophora+apiculata)+terhadap+gambaran+mikroskopis+arteri+koronaria+tikus+putih+jantan+(Rattus+norvegicus)+yang+diinduksi+diet+tinggi+lemak.+Metode%3A+Penelitian+ini+berupa+eksperimental+dengan+posttest+only+control+group+design+dilakukan+selama+30+hari+menggunakan+hewan+coba+Rattus+norvegicus+galur+Sparague+dawley+berjumlah+30+ekor.+Terdapat+6+kelompok+perlakuan%2C+yaitu+KN+hanya+diberikan+pakan+standar%2C+K%2B+diberi+induksi+kuning+telur+puyuh+dan+simvastatin+10+mg%2Fhari%2C+K-+diberi+induksi+kuning+telur+puyuh%2C+P1%2C+P2%2C+dan+P3+berturut-turut+diberi+induksi+kuning+telur+puyuh+dan+ekstrak+daun+Rhizophora+apiculata+dosis+56+mg%2FKgBB%2C+28+mg%2FKgBB%2C+dan+14+mg%2FKgBB.+Hasil+penelitian+ini+di+analisis+menggunakan+one-way+ANOVA+dan+dilanjutkan+dengan+uji+post-hoc.+Hasil%3A+Hasil+uji+normalitas+saphiro-wilk+dan+homogenitas+levene+mendapatkan+hasil+p%3E0%2C05.+Pada+uji+one-way+anova+diameter+dan+tebal+arteri+koronaria+mendapatkan+hasil+p%3C0%2C05+yang+menunjukkan+terdapat+perbedaan+bermakna+antar+kelompok.+Hasil+uji+post-hoc+LSD+pada+diameter+K-+memiliki+perbedaan+bermakna+dengan+P1%2CP2+dan+P3+dan+tebal+arteri+K-+memiliki+perbedaan+bermakna+dengan+P1+dan+P2+(p%3C0%2C05).++Kesimpulan%3A+Pemberian+ekstrak+etanol+95%25+daun+(Rhizopora+apiculata)+memiliki+efek+protektif+terhadap+gambaran+mikroskopis+arteri+koronara+pada+tikus+putih+jantan+(Rattus+norvegicus)+galur+Sprague+Dawley+yang+diinduksi+diet+tinggi+lemak+dengan+dosis+efektif+28+mg%2FkgBB.++Kata+Kunci%3A+Arteri+koronaria%2C+Dislipidemia%2C+dan+Rhizopora+apiculata+%0D%0A+%0D%0A++%0D%0A+%0D%0A++%0D%0AABSTRACT+%0D%0ATHE+EFFECT+LEAVES+Rhizophora+apiculata+ETHANOL+EXTRACT+ADMINISTRATION+OF+95%25+ON+HISTOPATOLOGY+OF+CORONARY+%0D%0AARTERIES+OF+MALE+WHITE+RATS+(Rattus+norvegicus)+INDUCED+HIGH-FAT+DIET+%0D%0ABy++%0D%0AINTAN+FITRIYANA++%0D%0ABackground%3A+Atherosclerosis+is+a+disease+caused+by+an+inflammatory+process+accompanied+by+an+accumulation+of+lipids+in+the+walls+of+the+arteries.+A+common+cause+of+atherosclerosis+is+dyslipidemia.+Leaves+Rhizophora+apiculata+contains+alkaloids%2C+flavonoids%2C+triterpenoids%2C+steroids%2C+saponins+and+tannins+which+function+as+antidyslipidemic+and+antioxidant.+The+purpose+of+this+study+was+to+determine+the+effect+of+95%25+ethanol+extract+leaves+Rhizophora+apiculata+on+the+microscopic+appearance+of+the+coronary+arteries+of+male+white+rats+(Rattus+norvegicus)+induced+by+a+high-fat+diet.+Methode%3A+This+research+was+an+experimental+study+with+a+posttest+only+control+group+design+carried+out+for+30+days+using+30+experimental+animals%2C+Rattus+norvegicus+Sparague+dawley+strain.+There+were+6+treatment+groups%2C+namely+KN+given+standard+feed+only%2C+K%2B+were+given+quail+egg+yolk+induction+and+simvastatin+10+mg%2Fday%2C+K-+was+given+quail+egg+yolk+induction%2C+P1%2C+P2%2C+and+P3+were+given+quail+egg+yolk+induction+and+leaf+extract%2C+respectively.+Leaves+Rhizophora+apiculata+doses+of+56+mg%2FKgBW%2C+28+mg%2FKgBW%2C+and+14+mg%2FKgBW.+The+results+of+this+study+were+analyzed+using+one-way+ANOVA+and+followed+by+a+post-hoc+test.+Result%3A+The+results+of+the+saphiro-wilk+normality+and+levene+homogeneity+test+results+were+p%3E0.05.+In+the+one-way+ANOVA+test%2C+the+diameter+and+thickness+obtained+p%3C0.05%2C+which+indicates+that+there+are+significant+differences+between+groups.+The+results+of+the+post-hoc+LSD+test+on+K-+diameter+had+a+significant+difference+with+P1%2C+P2+and+P3+and+K-+artery+thickness+had+a+significant+difference+with+P1+and+P2+(p%3C0.05).+Conclusion%3A+Administration+of+95%25+ethanol+extract+Rhizopora+apiculata+had+a+protective+effect+on+the+microscopic+appearance+of+the+coronary+arteries+in+male+white+rats+(Rattus+norvegicus)+Sprague+Dawley+strain+induced+by+a+high-fat+diet+with+an+effective+dose+28+mg%2FkgBW.+++Keyword%3A+Coronary+arteries%2C+dyslipidemia%2C+and+Rhizopora+apiculata.+%0D%0A+%0D%0A&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2022-07-01&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F64389%2F1%2F1.%2520ABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F64389%2F2%2F2.%2520SKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F64389%2F3%2F3.%2520SKRIPSI%2520TANPA%2520PEMBAHASAN.pdf&rft.identifier=+++INTAN+FITRIYANA+%2C+1858011052++(2022)+EFEK+PEMBERIAN+EKSTRAK+ETANOL+95%25+DAUN+(Rhizophora+apiculata)+TERHADAP+GAMBARAN+MIKROSKOPIS+ARTERI+KORONARIA+TIKUS+PUTIH+JANTAN+(Rattus+norvegicus)+YANG+DIINDUKSI+DIET+TINGGI+LEMAK.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F64389%2F