%0 Generic
%A   INTAN  FITRIYANA , 1858011052
%C UNIVERSITAS LAMPUNG
%D 2022
%F eprints:64389
%I FAKULTAS KEDOKTERAN
%T EFEK PEMBERIAN EKSTRAK ETANOL 95% DAUN (Rhizophora apiculata) TERHADAP GAMBARAN MIKROSKOPIS ARTERI KORONARIA TIKUS    PUTIH JANTAN (Rattus norvegicus) YANG  DIINDUKSI DIET TINGGI LEMAK 
%U http://digilib.unila.ac.id/64389/
%X       ABSTRAK   EFEK PEMBERIAN EKSTRAK ETANOL 95%  DAUN (Rhizophora apiculata) TERHADAP GAMBARAN MIKROSKOPIS   ARTERI KORONARIA TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI DIET TINGGI LEMAK    Oleh     INTAN FITRIYANA        Latar Belakang: Aterosklerosis merupakan suatu penyakit disebabkan oleh proses inflamasi yang disertai dengan adanya penimbunan pada lipid didinding arteri. Penyebab umum dari aterosklerosis adalah dislipidemia. Daun (Rhizophora apiculata) mengandung alkaloid, flavonoid, triterpenoid, steroid, saponin dan tannin yang berfungsi sebagai antidislipidemia dan antioksidan. Tujuan penelitian ini untuk mengetahui efek ekstrak etanol 95% daun (Rhizophora apiculata) terhadap gambaran mikroskopis arteri koronaria tikus putih jantan (Rattus norvegicus) yang diinduksi diet tinggi lemak. Metode: Penelitian ini berupa eksperimental dengan posttest only control group design dilakukan selama 30 hari menggunakan hewan coba Rattus norvegicus galur Sparague dawley berjumlah 30 ekor. Terdapat 6 kelompok perlakuan, yaitu KN hanya diberikan pakan standar, K+ diberi induksi kuning telur puyuh dan simvastatin 10 mg/hari, K- diberi induksi kuning telur puyuh, P1, P2, dan P3 berturut-turut diberi induksi kuning telur puyuh dan ekstrak daun Rhizophora apiculata dosis 56 mg/KgBB, 28 mg/KgBB, dan 14 mg/KgBB. Hasil penelitian ini di analisis menggunakan one-way ANOVA dan dilanjutkan dengan uji post-hoc. Hasil: Hasil uji normalitas saphiro-wilk dan homogenitas levene mendapatkan hasil p>0,05. Pada uji one-way anova diameter dan tebal arteri koronaria mendapatkan hasil p<0,05 yang menunjukkan terdapat perbedaan bermakna antar kelompok. Hasil uji post-hoc LSD pada diameter K- memiliki perbedaan bermakna dengan P1,P2 dan P3 dan tebal arteri K- memiliki perbedaan bermakna dengan P1 dan P2 (p<0,05).  Kesimpulan: Pemberian ekstrak etanol 95% daun (Rhizopora apiculata) memiliki efek protektif terhadap gambaran mikroskopis arteri koronara pada tikus putih jantan (Rattus norvegicus) galur Sprague Dawley yang diinduksi diet tinggi lemak dengan dosis efektif 28 mg/kgBB.  Kata Kunci: Arteri koronaria, Dislipidemia, dan Rhizopora apiculata                 ABSTRACT   THE EFFECT LEAVES Rhizophora apiculata ETHANOL EXTRACT ADMINISTRATION OF 95% ON HISTOPATOLOGY OF CORONARY   ARTERIES OF MALE WHITE RATS (Rattus norvegicus) INDUCED HIGH-FAT DIET   By    INTAN FITRIYANA    Background: Atherosclerosis is a disease caused by an inflammatory process accompanied by an accumulation of lipids in the walls of the arteries. A common cause of atherosclerosis is dyslipidemia. Leaves Rhizophora apiculata contains alkaloids, flavonoids, triterpenoids, steroids, saponins and tannins which function as antidyslipidemic and antioxidant. The purpose of this study was to determine the effect of 95% ethanol extract leaves Rhizophora apiculata on the microscopic appearance of the coronary arteries of male white rats (Rattus norvegicus) induced by a high-fat diet. Methode: This research was an experimental study with a posttest only control group design carried out for 30 days using 30 experimental animals, Rattus norvegicus Sparague dawley strain. There were 6 treatment groups, namely KN given standard feed only, K+ were given quail egg yolk induction and simvastatin 10 mg/day, K- was given quail egg yolk induction, P1, P2, and P3 were given quail egg yolk induction and leaf extract, respectively. Leaves Rhizophora apiculata doses of 56 mg/KgBW, 28 mg/KgBW, and 14 mg/KgBW. The results of this study were analyzed using one-way ANOVA and followed by a post-hoc test. Result: The results of the saphiro-wilk normality and levene homogeneity test results were p>0.05. In the one-way ANOVA test, the diameter and thickness obtained p<0.05, which indicates that there are significant differences between groups. The results of the post-hoc LSD test on K- diameter had a significant difference with P1, P2 and P3 and K- artery thickness had a significant difference with P1 and P2 (p<0.05). Conclusion: Administration of 95% ethanol extract Rhizopora apiculata had a protective effect on the microscopic appearance of the coronary arteries in male white rats (Rattus norvegicus) Sprague Dawley strain induced by a high-fat diet with an effective dose 28 mg/kgBW.   Keyword: Coronary arteries, dyslipidemia, and Rhizopora apiculata.