?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+HERBISIDA+PARAQUAT+DIKLORIDA%0D%0APER-ORAL+TERHADAP+PEMBENGKAKAN+HEPATOSIT+DAN+KONGESTI+SINUSOID+HATI+PADA+TIKUS+PUTIH+(Rattus+norvegicus)+JANTAN+GALUR+Sprague+dawley&rft.creator=Yolanda+Fratiwi%2C+1118011140&rft.subject=+&rft.subject=Karya+Karya+Umum+%3D+000&rft.description=abstrak+bahasa+indonesia+%3A%0D%0APenggunaan+herbisida+paraquat+diklorida+oleh+para+petani+sebagai+salah+satu+upaya+untuk+meningkatkan+hasil+produksi+pada+sektor+pertanian.+Herbisida+paraquat+diklorida+sering+digunakan+secara+sembarangan+dan+tidak+memperhatikan+label+peringatan.+Herbisida+yang+masuk+ke+dalam+tubuh+melalui+oral+dapat+menyebabkan+kerusakan+berbagai+organ%2C+salah+satunya+adalah+hati.+Penelitian+ini+bertujuan+untuk+mengetahui+pengaruh+pemberian+herbisida+paraquat+diklorida+per%E2%88%92oral+terhadap+pembengkakan+hepatosit+dan+kongesti+sinusoid+hati.%0D%0APenelitian+ini+bersifat+eksperimental+dengan+menggunakan+25+ekor+tikus+putih+jantan+galur+Sprague+dawley+yang+dibagi+menjadi+5+kelompok.+Masing-masing+kelompok+terdiri+dari+5+ekor+tikus+yang+diberi+perlakuan+selama+2+hari+dengan+dosis+yang+berbeda%2C+yaitu+K1+merupakan+kelompok+kontrol%2C+K2%2C+K3%2C+K4%2C+dan+K5+diberi+herbisida+paraquat+diklorida+25+mg%2FkgBB%2C+50+mg%2FkgBB%2C+100+mg%2FkgBB%2C+dan+200+mg%2FkgBB.%0D%0AHasil+penelitian+menunjukkan+rerata+skor+pembengkakan+hepatosit+dan+kongesti+sinusoid+mengalami+peningkatan.+Hasil+uji+Kruskal+Wallis+yang+dilanjutkan+uji+Post+Hoc+Mann+Whitney+menunjukkan+perbedaan+yang+bermakna+antar+kelompok+perlakuan+p%3D0%2C000+(p%3C0%2C05).+Pemberian+herbisida+paraquat+diklorida+per%E2%88%92oral+dapat+menyebabkan+pembengkakan+hepatosit+dan+kongesti+sinusoid+hati+tikus.%0D%0A%0D%0Aabstrak+bahasa+inggris+%3A%0D%0AThe+use+of+herbicide+paraquat+dichloride+by+farmers%2C+is+one+of+effort+to+increase+the+production+in+agricultural+sector.+Herbicide+paraquat+dichloride+often+used+by+farmers+carelessly+and+there+was+caution+ignorance.+Herbicide+cause+much+adverse+effect+to+organs%2C+especially+in+liver+through+oral.+The+purpose+of+this+study+is+to+determine+the+effect+of+oral+herbicide+paraquat+dichloride+to+hepatocyte+swelling+and+sinusoidal+congestion+in+liver+of+male+rats+(Rattus+novergicus)+Sprague+dawley+strain.%0D%0AIn+this+experimental+study%2C+25+male+rats+(Rattus+novergicus)+Sprague+dawley+strain+are+divided+randomly+into+5+group+and+treated+for+2+days.+K1+is+group+of+controlled%2C+K2%2C+K3%2C+K4%2C+K5+are+given+herbicide+paraquat+dichloride+25+mg%2FkgBW%2C+50+mg%2FkgBW%2C+100+mg%2FkgBW%2C+and+200+mg%2FkgBW.%0D%0AThe+results+showed+that+the+average+number+of+hepatocyte+swelling+and+sinusoidal+congestion+in+liver+was+increasing.+In+Kruskal+Wallis+test+and+Post+Hoc+Mann+Whitney+test+found+significant+difference+p%3D0.000+(p%3C0.005).+There+are+significant+effect+of+oral+paraquat+dichloride+to+hepatocyte+swelling+and+sinusoidal+congestion+in+liver+of+male+rats+(Rattus+novergicus)+Sprague+dawley+strain.&rft.publisher=Fakultas+Kedokteran&rft.date=2014-12-24&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F1%2F2.%2520ABSTRAK%2520INGGRIS.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F2%2F3.%2520ABSTRAK%2520INDONESIA.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F3%2F4.COVER%2520DALAM.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F4%2F5.PERSETUJUAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F5%2F6.MENGESAHKAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F6%2F7.PERNYATAAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F7%2F8.%2520RIWAYAT%2520HIDUP.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F8%2F9.%2520PERSEMBAHAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F9%2F10.%2520SANWACANA.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F10%2F11.%2520DAFTAR%2520ISI.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F11%2F12.%2520DAFTAR%2520TABEL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F12%2F13.%2520DAFTAR%2520GAMBAR.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F13%2F14.%2520DAFTAR%2520LAMPIRAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F14%2F15.%2520BAB%25201.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F15%2F16.%2520BAB%25202.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F16%2F17.%2520BAB%25203.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F17%2F18.%2520BAB%25204.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6483%2F18%2F19.%2520BAB%25205.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigi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