?url_ver=Z39.88-2004&rft_id=1817011003&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=OPTIMASI+DAN+VALIDASI+METODE+PENENTUAN+KADAR+RESIDU%0D%0AANTIBIOTIK+TETRASIKLIN+PADA+IKAN+MAS+(Cyprinus+carpio)%0D%0ADENGAN+KROMATOGRAFI+CAIR+KINERJA+TINGGI+(KCKT)&rft.creator=++YANESTA+OXVYENA%2C+1817011003&rft.subject=540+Kimia+dan+ilmu+yang+berhubungan&rft.description=Telah+dilakukan+penelitian+tentang+validasi+metode+penentuan+kadar+residu%0D%0Aantibiotik+tetrasiklin+pada+ikan+mas+(Cyprinus+carpio)+menggunakan+Kromatografi%0D%0ACair+Kinerja+Tinggi+(KCKT).+Metode+KCKT+digunakan+dalam+analisis+karena%0D%0Amemiliki+kelebihan%2C+seperti+akurat%2C+efektif%2C+efisien%2C+mudah+dalam+pengoperasian%2C%0D%0Aserta+selektivitas+dan+sensitivitasnya+tinggi.+Penelitian+ini+bertujuan+untuk%0D%0Amengembangkan+metode+penentuan+residu+tetrasiklin+dan+mengetahui+kadar%0D%0Aresidu+antibiotik+tetrasiklin+dalam+daging+ikan+mas+dengan+KCKT+yang+diperoleh%0D%0Adari+8+pasar+di+Kota+Bandar+Lampung.+Optimasi+metode+analisis+yang+dilakukan%0D%0Aadalah+optimasi+komposisi+dan+laju+alir+fase+gerak.+Hasil+optimasi+menunjukkan%0D%0Akomposisi+asetonitril+%3A+air+%3D+35+%3A+65+dan+laju+alir+0%2C5+mL%2Fmenit.+Parameter+validasi%0D%0Ametode+yang+dilakukan+pada+penelitian+ini+adalah+linearitas%2C+presisi%2C+akurasi%2C%0D%0Aselektivitas%2C+LoD+dan+LoQ.+Hasil+linearitas+yang+diperoleh+dari+penelitian+ini%0D%0Aadalah+r+%3D+0%2C9980.+Metode+ini+memiliki+presisi+repeatability+dengan+nilai+%25RSD%0D%0A1%2C35%25+dan+presisi+reproducibility+dengan+nilai+%25RSD+berturut-turut+1%2C11%25%3B%0D%0A0%2C96%25%3B+dan+1%2C14%25.+Nilai+%25recovery+metode+sebesar+101%2C05%25.+Nilai+LoD+dan+LoQ%0D%0Ametode+ini+sebesar+0%2C27+ppm+dan+0%2C90+ppm.+Pengukuran+kadar+residu+antibiotik%0D%0Atetrasiklin+dan+nilai+ketidakpastiannya+pada+sampel+ikan+mas+dari+8+lokasi+pasar+di%0D%0ABandar+Lampung+menunjukkan+nilai+sebesar+29%2C28+%C2%B1+1%2C12+ppm%3B+21%2C77+%C2%B1+1%2C07%0D%0Appm%3B+32%2C70+%C2%B1+1%2C23+ppm%3B+21%2C89+%C2%B1+0%2C87+ppm%3B+32%2C10+%C2%B1+1%2C21+ppm%3B+38%2C58+%C2%B1+1%2C42+ppm%3B%0D%0A23%2C13+%C2%B1+0%2C91+ppm%3B+dan+24%2C70+%C2%B1+0%2C97+ppm.+Hasil+validasi+metode+menunjukkan%0D%0Abahwa+metode+tersebut+dapat+digunakan+untuk+analisis+kadar+antibiotik+tetrasiklin%0D%0Asecara+rutin+di+laboratorium.%0D%0AKata+kunci%3A+Validasi+metode%2C+KCKT%2C+antibiotik+tetrasiklin%2C+kadar%2C+ketidakpastian%0D%0Apengukuran%0D%0A%0D%0AThe+method+validation+for+determination+the+residue+levels+of+tetracycline%0D%0Aantibiotics+in+carp+(Cyprinus+carpio)+has+been+carried+out+using+High+Performance%0D%0ALiquid+Chromatography+(HPLC).+The+advantages+of+the+HPLC+method+are%0D%0Aaccurate%2C+effective%2C+efficient%2C+easy+to+operate%2C+and+has+high+selectivity+and%0D%0Asensitivity.+The+research+purposes+is+to+expand+a+method+for+determining%0D%0Atetracycline+residues+and+to+determine+the+residual+levels+of+tetracycline+antibiotics%0D%0Ain+carp+from+8+markets+in+Bandar+Lampung+City+using+HPLC.+The+method%0D%0Aoptimation+carried+out+are+mobile+phase+composition+and+flow+rate.+The%0D%0Aoptimation+results+show+the+composition+of+acetonitrile+%3A+water+%3D+35+%3A+65+and+a%0D%0Aflow+rate+of+0.5+mL%2Fminute.+Parameters+used+in+this+research+are+linearity%2C%0D%0Aprecision%2C+accuracy%2C+selectivity%2C+LoD+and+LoQ.+The+linearity+result+obtained+is+r+%3D%0D%0A0.9980.+This+method+has+repeatability+precision+with+%25RSD+value+1%2C35%25+and%0D%0Areproducibility+precision+with+%25RSD+value+1%2C11%25%3B+0%2C96%25%3B+and+1%2C14%25%0D%0Arespectively.+The+value+of+%25+recovery+method+is+101%2C05%25.+The+LoD+and+LoQ%0D%0Avalues+of+this+method+are+0%2C27+ppm+and+0%2C90+ppm.+Measurement+value+of%0D%0Atetracycline+antibiotic+residue+levels+and+their+uncertainty+values+in+carp+samples%0D%0Afrom+8+market+locations+in+Bandar+Lampung+are+of+29%2C28+%C2%B1+1%2C12+ppm%3B+21%2C77+%C2%B1%0D%0A1%2C07+ppm%3B+32%2C70+%C2%B1+1%2C23+ppm%3B+21%2C89+%C2%B1+0%2C87+ppm%3B+32%2C10+%C2%B1+1%2C21+ppm%3B+38%2C58+%C2%B1+1%2C42%0D%0Appm%3B+23%2C13+%C2%B1+0%2C91+ppm%3B+dan+24%2C70+%C2%B1+0%2C97+ppm.+The+method+validation+results%0D%0Aindicate+that+this+method+can+be+used+for+routine+analysis+of+tetracycline+antibiotic%0D%0Alevels+in+the+laboratory.%0D%0AKeywords%3A+Method+validation%2C+HPLC%2C+tetracycline+antibiotics%2C+levels%2C%0D%0Ameasurement+uncertainty&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2022-08-03&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F65163%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F65163%2F3%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F65163%2F2%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=+++YANESTA+OXVYENA%2C+1817011003++(2022)+OPTIMASI+DAN+VALIDASI+METODE+PENENTUAN+KADAR+RESIDU+ANTIBIOTIK+TETRASIKLIN+PADA+IKAN+MAS+(Cyprinus+carpio)+DENGAN+KROMATOGRAFI+CAIR+KINERJA+TINGGI+(KCKT).++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN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