?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+EKSTRAK+DAUN+PEGAGAN+(Centella+asiatica+%5BL.%5D+Urban)+TERHADAPcGAMBARAN+HISTOPATOLOGIScHEPAR+%0D%0ATIKUScPUTIH+(Rattuscnorvegicus)+GALURcSPARAGUE+DAWLEYcYANG+DIINDUKSIcETANOL+%0D%0A&rft.creator=Sinta+Meidina%2C+1658011010+&rft.subject=000+Ilmu+komputer%2C+informasi+dan+pekerjaan+umum&rft.subject=080+Kumpulan+karya+umum&rft.description=++%0D%0AABSTRAK++PENGARUH+PEMBERIAN+EKSTRAK+DAUN+PEGAGAN+(Centella+asiatica+%0D%0A%5BL.%5D+Urban)+TERHADAP+GAMBARAN+HISTOPATOLOGIS+HEPAR+TIKUS+PUTIH+(Rattus+norvegicus)+GALUR+SPARAGUE+DAWLEY+YANG+%0D%0ADIINDUKSI+ETANOL++%0D%0AOLEH+SINTA+MEIDINA+%0D%0A+Latar+Belakang%3A+Badan+Pusat+Statistik+(BPS)+konsumsi+alkohol+di+Indonesia+%0D%0Atercatat+sebesar+0%2C36+liter+per+kapita.+Sedangkan+konsumsi+alkohol+di+perkotaan+tercatat+sebesar+0%2C18+liter+per+kapita%2C+itu+menjadi+masalah+besar.+Konsumsi+alkohol+yang+berlebihan+akan+dikaitkan+dengan+kerusakan+hepar%2C+baik+dalam+jangka+waktu+cepat+ataupun+jangka+panjang%2C+selain+itu+juga+bisa+menyebabkan+kanker.+Dalam+rangka+masyarakat+melakukan+usaha+back+to+nature%2C+salah+satu+tanaman+terpilihnya+adalah+daun+pegagan.+Penelitian+ini+bertujuan+untuk+meneliti+apakah+terdapat+pengaruh+pemberian+ekstrak+daun+pegagan+(Centella+asiastica+%5BL.%5D+Urban)+terhadap+gambaran+histopatologis+hepar+tikus+putih+(Rattus+norvegicus)+galur+sparague+dawley+yang+diinduksi+etanol.+%0D%0AMetode%3A+Penelitian+ini+menggunakan+30+ekor+tikus+yang+dibagi+menjadi+5+kelompok%2C+yaitu+kelompok+kontrol+1+(K1)%2C+kelompok+kontrol+2+(K2)+yang+hanya+diberi+etanol+tanpa+ekstrak+daun+pegagan%2C+kelompok+perlakuan+1%2C+2%2C+dan+3+yang+diberikan+etanol+2mL%2Fhari+dan+dilanjutkan+dengan+pemberian+esktrak+daun+pegagan+dengan+dosis+berturut-turut+10mg%2FKgBB%2C+20mg%2FKgBB%2C+dan+40mg%2FKgBB+selama+14+hari.+%0D%0AHasil%3A+Hasil+rerata+skor+kerusakan+hepar+yang+didapatkan+adalah+K1%3D+181%2C4%3B+K2%3D+271%2C8%3B+P1%3D+243%2C6%3B+P2%3D+228%2C4%3B+P3%3D+208%2C8.+Data+diuji+dengan+Shapiro-wilk+silanjutkan+dengan+uji+post+hoc+Tamhane%E2%80%99s+dan+didapatkan+adanya+perbedaan+rerata+yang+bermakna+antara+kelompok+kontrol+dan+kelompok+perlakuan.+Dari+hasil+rerata+tersebut+dapat+dilihat+peningkatan+dosis+daun+pegagan+berfungsi+sebagai+hepatoprotektor+%0D%0AKesimpulan%3A+Terdapat+pengaruh+ekstrak+daun+pegagan+terhadap+gambaran+histopatologi+hepar+tikus+putih+(Rattus+norvegicus)+jantan+sparague+dawley+yang+diinduksi+etanol.+%0D%0AKata+kunci%3A+alkohol%2C+daun+pegagan%2C+hepatoprotektor%2C+histopatologi+hepar.+%0D%0A%0D%0A+++%0D%0AABSTRACT++%0D%0ATHE+EFFECT+OF+GIVING+GOTU+KOLA+(Centella+asiatica+%5BL.%5D+Urban)+LEAVE+EXTRACT+ON+LIVER+HISTOPATHOLOGICAL+DESCRIPTION+%0D%0AOF+ETHANOL-INDUCED+WHITE+RAT+(Rattus+norvegicus)+SPARAGUE+DAWLEY+STRAIN+INDUCTED+BY+ETHANOL+%0D%0A+BY+%0D%0ASINTA+MEIDINA++%0D%0ABackground%3A+Central+Bureau+of+Statistics+(BPS)+alcohol+consumption+in+Indonesia+is+recorded+at+0.36+liters+per+capita.+While+alcohol+consumption+in+urban+areas+was+recorded+at+0.18+liters+per+capita%2C+it+became+a+big+problem.+Excessive+alcohol+consumption+will+be+associated+with+liver+damage%2C+either+in+the+short+term+or+long+term%2C+but+it+can+also+cause+cancer.+In+order+for+the+community+to+do+business+back+to+nature%2C+one+of+the+plants+chosen+is+gotu+kola+leaf.+This+study+aims+to+examine+whether+there+is+an+effect+of+giving+gotu+kola+(Centella+asiastica+%5BL.%5D+Urban)+leaf+extract+on+the+histopathological+picture+of+the+liver+of+white+rats+(Rattus+norvegicus)+sparague+dawley+strain+induced+by+ethanol.+%0D%0AMethod%3A+This+study+used+30+rats+divided+into+5+groups%2C+that+control+group+1+(K1)given+aquades%2C+control+group+2+(K2)+only+given+ethanol+without+giving+gotu+kola+leaf+extract%2C+treatment+groups+1%2C+2%2C+and+3+given+ethanol+2mL%2Fday+orally+followed+by+gotu+kola+leaf+extract+with+successive+doses+of+10+mg%2FKgBW%2C+20mg%2FKgBW%2C+and+40mg%2FKgBW+for+14+days.+%0D%0AResult%3A+The+average+liver+damage+score+obtained+were+K1+%3D+181.4%3B+K2%3D+271.8%3B+P1%3D+243.6%3B+P2%3D+228.4%3B+P3%3D+208.8.+The+data+were+tested+with+Shapiro-wilk+followed+by+Tamhane's+post+hoc+test+and+it+was+found+that+there+was+a+significant+mean+difference+between+the+control+group+and+the+treatment+group.+%0D%0AConclusion%3A+There+is+an+effect+of+gotu+kola+(Centella+asiatica)+leaf+extract+on+liver+histopathology+on+white+rats+male+Sparague+dawley+rats+(Rattus+norvegicus)+strain+induced+by+ethanol.+%0D%0AKeyword%3A+alcohol%2C+gotu+kola+leaf%2C+hepatoprotector%2C+liver+histopathology.+&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2022-07-21&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F65457%2F1%2F1.%2520ABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F65457%2F3%2F2.%2520SKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F65457%2F2%2F3.%2520SKIRPSI%2520TANPA%2520PEMBAHASAN.pdf&rft.identifier=++Sinta+Meidina%2C+1658011010+++(2022)+PENGARUH+PEMBERIAN+EKSTRAK+DAUN+PEGAGAN+(Centella+asiatica+%5BL.%5D+Urban)+TERHADAPcGAMBARAN+HISTOPATOLOGIScHEPAR+TIKUScPUTIH+(Rattuscnorvegicus)+GALURcSPARAGUE+DAWLEYcYANG+DIINDUKSIcETANOL.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F65457%2F