?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+EKSTRAK+DAUN+SIRSAK(Annona+muricata+L.)+TERHADAP+AKTIVITAS+ENZIM+KATALASE+PADA+JARINGAN+HATI+TIKUS+PUTIH+(Rattus+norvegicus)+GALUR+SPRAGUE+DAWLEY+YANG+DIINDUKSI+SENYAWA+7%2C12+DIMETHYLBENZ%5B%CE%B1%5DANTHRACENE+(DMBA)&rft.creator=Taufiqurrohman%2C+1118011132&rft.subject=+&rft.description=Abstrak+Bahasa+Indonesia%0D%0A%0D%0AKanker+hati+adalah+penyebab+kedua+kematian+akibat+kanker+di+seluruh+dunia.+Tubuh+memiliki+pertahanan+antioksidan+terhadap+kanker+seperti+enzim+katalase.+Namun+pada+kanker%2C+antioksidan+dalam+tubuh+tidak+seimbang+sehingga+dibutuhkan+antioksidan+eksogen.+Sirsak+merupakan+alternatif+pengobatan+kanker%2C+karena+memiliki+antioksidan+pada+daunnya.+Penelitian+ini+bertujuan+untuk+mengetahui+pengaruh+pemberian+ekstrak+daun+sirsak+terhadap+aktivitas+enzim+katalase+pada+hati+tikus+putih+galur+Sprague+dawley+yang+diinduksi+DMBA.+Penelitian+ini+merupakan+penelitian+eksperimental+menggunakan+20+tikus+putih+betina+yang+dibagi+menjadi+4+kelompok+dan+diberi+perlakuan+selama+4+minggu.++Kelompok+K+(diberi+aquades+1+mL%2Fhari)%2C+A+(diinduksi+senyawa+DMBA+20mg%2FkgBB+2x%2Fminggu+dan+diberi+aquades+1+mL%2Fhari)%2C+B+(diberi+DMBA+20mg%2FkgBB+2x%2Fminggu+dan+ekstrak+daun+sirsak+20+mg%2FkgBB%2Fhari)%2C+C+(diberi+DMBA+20mg%2FkgBB+2x%2Fminggu+dan+ekstrak+daun+sirsak+40+mg%2FkgBB%2Fhari).+Tikus+diterminasi+lalu+diambil+hatinya+dan+dilakukan+uji+aktivitas+katalase.+Hasil+penelitian+menunjukkan+rerata+aktivitas+katalase+kelompok+K+yaitu+0%2C00033+U%2Fmg%2C+A+yaitu+0%2C00014+U%2Fmg%2C+B+yaitu+0%2C00019+U%2Fmg%2C+dan+C+yaitu+0%2C00036+U%2Fmg.+Secara+statistik+terdapat+perbedaan+yang+bermakna+pada+uji+one+way+ANNOVA+(p%3C0%2C05)+dan+uji+Post-Hoc+LSD+(p%3C0%2C05).+Hasil+uji+tersebut+memperlihatkan+bahwa+kelompok+C+dosis+40+mg%2FkgBB+memiliki+efek+antioksidan+dan+antikanker+yang+paling+baik.%0D%0A%0D%0AKata+kunci%3A+Daun+sirsak%2C+DMBA%2C+Hati%2C+Katalase%0D%0A%0D%0AAbstract+Bahasa+Inggris%0D%0A%0D%0ALiver+cancer+is+the+second+leading+cause+of+cancer+deaths+worldwide.+The+body+has+antioxidant+defenses+against+cancer+as+the+catalase+enzyme.+But+in+cancer%2C+antioxidants+in+the+body+out+of+balance+so+needed+exogenous+antioxidants.+Soursop+is+an+alternative+cancer+treatment%2C+because+it+has+antioxidants+in+leaves.+This+study+aimed+to+determine+the+effect+of+soursop+leaves+extract+to+catalase+enzyme+activity+in+the+liver+of+Sprague+Dawley+rat+induced+by+DMBA+.+This+study+was+an+experimental+study+using+20+female+rats+were+divided+into+4+groups+and+treated+for+4+weeks.+Group+K+(given+distilled+water+1+mL%2Fday)%2C+A+(DMBA+induced+compound+20+mg%2Fkgb.w+2x%2Fweek+and+were+given+distilled+water+1+mL%2Fday)%2C+B+(given+DMBA+20+mg%2Fkgb.w+2x%2Fweek+and+soursop+leaf+extract+20+mg%2Fkg%2Fday)%2C+C+(DMBA+was+given+20+mg%2Fkgb.w+2x%2Fweek+and+soursop+leaf+extract+40+mg%2Fkg%2Fday).+Rat+terminated+then+taken+liver+and+catalase+activity+test.+The+results+showed+a+mean+activity+of+catalase+group+K+is+0.00033+U%2Fmg%2C+A+is+0.00014+U%2Fmg%2C+B+is+0.00019+U%2Fmg%2C+and+C+is+0.00036+U%2Fmg.+Statistically+significant+difference+in+one+way+Annova+test+(p%3C0.05)+and+the+Post-hoc+LSD+test+(p%3C0.05).+The+test+results+showed+that+the+group+C+dose+of+40+mg%2Fkg+has+antioxidant+and+anticancer+effects+that+is+the+most+well.%0D%0A%0D%0AKey+word%3A+Catalase%2C+DMBA%2C+Liver%2C+Soursop+leaves%0D%0A%0D%0A%0D%0A&rft.publisher=Fakultas+Kedokteran&rft.date=2015-01-22&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6570%2F1%2F2.%2520ABSTRAK%2520INDO.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6570%2F2%2F3.%2520ABSTRACT%2520ENGLISH.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6570%2F3%2F4.%2520COVER%2520DALAM.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6570%2F4%2F5.%2520LEMBAR%2520PERSETUJUAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6570%2F5%2F6.%2520LEMBAR%2520PENGESAHAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6570%2F6%2F7.%2520SURAT%2520PERNYATAAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6570%2F7%2F8.%2520RIWAYAT%2520HIDUP.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6570%2F8%2F9.%2520PERSEMBAHAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6570%2F9%2F10.%2520MOTO.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6570%2F10%2F11.%2520SANWACANA.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6570%2F11%2F12.%2520DAFTAR%2520ISI.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6570%2F12%2F13.%2520DAFTAR%2520TABEL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6570%2F13%2F14.%2520DAFTAR%2520LAMPIRAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F6570%2F14%2F15.%2520DAFTAR%2520GAMBAR.pdf&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