?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=%0D%0A%0D%0A%0D%0A%0D%0A%0D%0A+%0D%0ASINTESIS%2C+KARAKTERISASI%2C+DAN+UJI+AKTIVITAS+SENYAWA%0D%0AKOMPLEKS+Cr(III)-LEUSIN+DAN+Cu(II)-LEUSIN+SEBAGAI+%0D%0AANTIDIABETES%0D%0A+&rft.creator=+NAURA+TADZKIANA+NADIFA+%2C+1717011084&rft.subject=000+Ilmu+komputer%2C+informasi+dan+pekerjaan+umum&rft.subject=001+Ilmu+pengetahuan&rft.description=%0D%0A%0D%0A+%0D%0ASuplemen+antidiabetes+diketahui+terdapat+di+senyawa+kromium+(III)+dan+tembaga%0D%0A(II).++Suplemen+antidiabetes+dapat+diperoleh+dengan+mensintesis+senyawa+kompleks%0D%0ACr(III)%2C+Cu(II)+dengan+asam+amino.++Penyakit+diabetes+melitus+ditandai+dengan%0D%0Apeningkatan+kadar+glukosa+dalam+darah+akibat+gangguan+sekresi+insulin.+%0D%0APengobatan+berupa+obat-obatan+berbasis+logam+seperti+kompleks+dapat+digunakan%0D%0Asebgai+antidiabetes.++Penelitian+ini+dilakukan+untuk+mendapatkan+senyawa%0D%0Akompleks+%5BCr(leu)%0D%0A3%0D%0A%5D+%2C%5BCu(leu)%0D%0A2%0D%0A%5D+dan+untuk+menguji+pengaruh+senyawa+kompleks%0D%0Aterhadap+kadar+glukosa+darah.++Sintesis+dilakukan+menggunakan+refluks+dan%0D%0Afreezdryer%2C+senyawa+hasil+sintesis+di+karakterisasi+menggunakan+spektrofotometer%0D%0AUv-Vis+dan+spektrofotometer+IR.++Hasil+karakterisasi+spektrofotometer+Uv-Vis%0D%0Asenyawa+kompleks+%5BCr(leu)%0D%0A3%0D%0A%5D+yaitu+pada+panjang+gelombang+415+nm+dan+566+nm%0D%0Adan+senyawa+kompleks+%5BCu(leu)%0D%0A2%0D%0A%5D+yaitu+pada+737+nm.++Hasil+spektrum%0D%0Aspektrofotometer+IR+senyawa+kompleks+%5BCr(leu)%0D%0A3%0D%0A%5D+menunjukkan+adanya+gugus+CrN%0D%0Adan%0D%0ACr-O%0D%0Apada%0D%0Adaerah%0D%0A468%2C70%0D%0Acm%0D%0A-1%0D%0A+dan+597%2C93+cm%0D%0A-1%0D%0A+serta+pada+senyawa+kompleks%0D%0A%5BCu(leu)%0D%0A2%0D%0A%5D+terdapat+serapan+Cr-N+dan+Cr-O+yaitu+432%2C05+cm%0D%0A-1%0D%0A+dan+586%2C36+cm%0D%0A.+%0D%0ASintesis+senyawa+kompleks+%5BCr(leu)%0D%0A3%0D%0A%5D+didapatkan+padatan+hijau+keabuan+dengan%0D%0Arendemen+72+%25+dan+%5BCu(leu)%0D%0A2%0D%0A%5D+berwarna+biru+dengan+rendemen+99+%25.++Senyawa%0D%0Ahasil+sintesis+dilanjutkan+pengujian+aktivitas+antidiabetes+secara+in-vivo.++Data+yang%0D%0Adiperoleh+diuji+One-Way+ANOVA+dan+dilanjutkan+dengan+BNT+pada+taraf+nyata%0D%0A5%25.++Pemberian+dosis+yang+menurunkan+glukosa+darah+senyawa+kompleks%0D%0A%5BCr(leu)%0D%0A3%0D%0A%5D+yang+paling+baik+pada+dosis+200+%CE%BCg%2FKgBB+sebanyak+61%25+(132%2C0+%C2%B1%0D%0A27%2C22)%0D%0Aa%0D%0A%2C+sedangkan+pemberian+dosis+senyawa+kompleks+%5BCu(leu)%0D%0A2%0D%0A%5D+yang%0D%0Amenurunkan+kadar+glukosa+darah+paling+baik+dosis+100+%CE%BCg%2FKgBB+sebesar+45%25%0D%0A(107%2C3+%C2%B1+11%2C93)%0D%0Aa%0D%0A.++Penurunan+kadar+gula+darah+yang+terjadi+membuktikan+bahwa%0D%0Asenyawa+kompleks+dapat+menjadi+suplemen+antidiabetes.%0D%0A%0D%0AKata+kunci+%3A+Antidiabetes%2C+karakterisasi%2C+senyawa+kompleks%2C+sintesis.+%0D%0A-1%0D%0A%0D%0A%0D%0A%0D%0A+%0D%0AAntidiabetic+supplements+are+known+to+be+found+in+compounds+of+chromium+(III)%0D%0Aand+copper+(II).+Antidiabetic+supplements+can+be+obtained+by+synthesizing+complex%0D%0Acompounds+Cr(III)%2C+Cu(II)+with+amino+acids.+Diabetes+mellitus+is+characterized+by%0D%0Aincreased+levels+of+glucose+in+the+blood+due+to+impaired+insulin+secretion.+Treatment%0D%0Ain+the+form+of+metal-based+drugs+such+as+complexes+can+be+used+as+antidiabetic.%0D%0AThis+research+was+conducted+to+obtain+complex+compounds+%5BCr(leu)%0D%0A3%0D%0A%5D%0D%0Aand+to+examine+the+effect+of+complex+compounds+on+blood+glucose+levels.+The%0D%0Asynthesis+was+carried+out+using+reflux+and+a+freezer%2C+the+synthesized+compounds%0D%0Awere+characterized+using+a+UV-Vis+spectrophotometer+and+an+IR%0D%0Aspectrophotometer.+The+results+of+the+Uv-Vis+spectrophotometer+characterization%0D%0Aof+complex+compounds+%5BCr(leu)3%5D+are+at+wavelengths+of+415+nm+and+566+nm+and%0D%0Acomplex+compounds+%5BCu(leu)%0D%0A2%0D%0A%5D+are+at+737+nm.+The+results+of+the+IR%0D%0Aspectrophotometer+for+the+complex+compound+%5BCr(leu)%0D%0A3%0D%0A%5D+showed+the+presence+of%0D%0ACr-N+and+Cr-O+groups+in+the+468.70+cm-1+and+597.93+cm-1+regions+and+in+the%0D%0Acomplex+compound+%5BCu(leu)%0D%0A2%0D%0A%5D+there+were+the+uptake+of+Cr-N+and+Cr-O+were+432.05%0D%0Acm-1+and+586.36+cm-1.+The+synthesis+of+the+complex+compound+%5BCr(leu)%0D%0A3%0D%0A%5D+was%0D%0Afound+to+be+a+gray-green+solid+with+a+yield+of+72%25+and+a+blue+%5BCu(leu)%0D%0A2%0D%0A%5D+with+a+yield%0D%0Aof+99%25.+The+synthesized+compound+was+continued+with+in+vivo+antidiabetic+activity%0D%0Atesting.+The+data+obtained+were+tested+by+One-Way+ANOVA+and+continued+with%0D%0ABNT+at+a+5%25+significance+level.+Administration+of+a+dose+that+lowers+blood+glucose%0D%0Aof+the+complex+compound+%5BCr(leu)%0D%0A3%0D%0A%5D+%2C%5BCu(leu)%0D%0A2%0D%0A%5D+was+the+best+at+a+dose+of+200+g%2FKgBW+as+much%0D%0Aas+61%25+(132.0+%C2%B1+27.22)a%2C+while+the+administration+of+a+dose+of+complex+compound%0D%0A%5BCu(leu)2%5D+which+reduces+blood+glucose+levels+the+best+at+a+dose+of+100+g%2FKgBW%0D%0Aby+45%25+(107.3+%C2%B1+11.93)a.+The+decrease+in+blood+sugar+levels+that+occurs+proves+that%0D%0Athe+complex+compound+can+be+an+antidiabetic+supplement.%0D%0A%0D%0AKeywords%3A+Antidiabetic%2C+characterization%2C+complex+compounds%2C+synthesis.+&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2022-08-09&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F65976%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F65976%2F3%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F65976%2F2%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=+++NAURA+TADZKIANA+NADIFA+%2C+1717011084++(2022)++SINTESIS%2C+KARAKTERISASI%2C+DAN+UJI+AKTIVITAS+SENYAWA+KOMPLEKS+Cr(III)-LEUSIN+DAN+Cu(II)-LEUSIN+SEBAGAI+ANTIDIABETES.++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F65976%2F