?url_ver=Z39.88-2004&rft_id=1657011002&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=ISOLASI+DAN+KARAKTERISASI+SENYAWA+BIOAKTIF+FUNGI+%0D%0AAspergillus+nomiae+A12-RF+YANG+BERASOSIASI+DENGAN+SPONS+SEBAGAI+ANTIBAKTERI+TERHADAP+ISOLAT+KLINIS+%0D%0AStaphylococcus+aureus&rft.creator=ZAHRAH+KHAIRANI%2C+1657011002&rft.subject=000+Ilmu+komputer%2C+informasi+dan+pekerjaan+umum&rft.description=Penelitian+ini+bertujuan+menemukan+senyawa+antibakteri+S.+aureus+dari+fungi+A.+nomiae+A12-RF+berasosiasi+dengan+spons+laut.+Isolat+fungi+A.+nomiae+A12-RF+diperoleh+dari+deposit+UPT-LTSIT%2C+Universitas+Lampung.+Isolat+tersebut+diremajakan+dengan+TSB+dan+Malt+Ekstrak.+Hari+ke-7+terlihat+miselium+berwarna+putih.+Pengamatan+mikroskopis+dari+hasil+peremajaan+ditemukan+spora%2C+konidia%2C+konidiofor%2C+dan+sporangium+secara+rinci+pada+perbesaran+400x.+Isolat+dikultivasi+secara+Solid+State+Fermentation+(SSF)+secara+statis+dengan+media+kulit+udang+selama+21+hari.+Biomassa+fungi+dimaserasi+dengan+pelarut+EtOAC.+Hasil+uji+KLT+terhadap+ekstrak+kasar+menghasilkan+noda+positif+pada+pereaksi+(Ce2SO4)3+(RF+0%2C8+dan+RF+0%2C9)%2C+Dragendorf+(RF+0%2C85+dan+RF+0%2C88)%2C+dan+Ninhidrin+(RF+0%2C6%2C+RF+0%2C75%2C+dan+RF+0%2C8).+Ekstrak+kasar+tersebut+menunjukkan+kemampuan+antibakteri+terhadap+S.+aureus+klinis.+Scale+up+selanjutnya+dilakukan+dalam+6+Erlenmeyer+2+L%2C+diperoleh+6+g+ekstrak+kasar.+Hasil+scale+up+difraksinasi+dengan+kromatografi+kolom+terbuka.+Diperoleh+fraksi+24+(CF1-40F24)+yang+tidak+terlalu+banyak+noda.+CF1-40F24+positif+dengan+uji+KLT+pada+UV+254+nm+dan+pada+pereaksi+(Ce2SO4)3+(RF+0%2C68+dan+RF+0%2C7)%2C+Dragendorf+(RF+0%2C68+dan+RF+0%2C8)%2C+dan+Ninhidrin+(RF+0%2C68+dan+RF+0%2C7).+F-24+memiliki+aktivitas+antibakteri+terhadap+S.+Aureus+pada+konsentrasi+450+%C2%B5g%2F%C2%B5L+dengan+persentase+inhibisi+23%2C031%25.+Data+LC-MS%2FMS+menunjukkan+bahwa+fraksi+tersebut+diprediksi+memiliki+formula+molekul+C38H48N9O6+dengan+m%2Fz+726+serta+terkandung+senyawa+alkaloid+dan+peptida.+Konfirmasi+dengan+FTIR+memperlihatkan+bahwa+senyawa+tersebut+mengandung+gugus+gugus+N-H+pada+serapan+3272+cm-1%2C+C-H+pada+serapan+2929+cm-1%3B+overtune+benzene+pada+serapan+2079+cm-1%3B+dan+gugus+C%3DN%2C+1669+cm-1%2C+1602+cm-1+dan+1535+cm-1.%0D%0A%0D%0AKata+Kunci+%3A+antibakteri%2C+fungi%2C+Aspergillus+nomiae%2C+Staphylococcus+aureus+%0D%0A%0D%0A%0D%0A%0D%0A%0D%0A%0D%0A%0D%0Aabstract%0D%0A%0D%0AStaphylococcus+aureus+resistance+is+a+serious+problem+in+the+world.+This+study+purpose+to+observe+the+antibacterial+compound+to+againts+S.+aureus+from+the+fungi+A.+nomiae+A12-RF+associated+with+marine+sponges.+Fungal+isolate+A.+nomiae+A12-RF+was+obtained+from+the+UPT-LTSIT+deposit%2C+University+of+Lampung.+The+isolate+was+rejuvenated+with+TSB+and+Malt+Extract+and+it+was+observed+that+the+fungus+had+a+white+homogeneous+color.+Microscopic+observations+observed+spores%2C+conidia%2C+conidiophores%2C+and+sporangium+in+detail+at+400x+magnification.+Solid+State+Fermentation+(SSF)+of+shrimp+shells+for+21+days+and+observed+red+shrimp+shells+with+more+fungi+growing.+Fungal+biomass+was+macerated+with+EtOAC+solvent.+The+TLC+test+observed+that+crude+extract+was+positive+for+the+reagents+(Ce2SO4)3+(RF+0.8+and+RF+0.9)%2C+Dragendorf+(RF+0.85+and+RF+0.88)%2C+and+Ninhydrin+(RF+0.6%2C+RF+0.75).+%2C+and+RF+0.8).+The+crude+extract+showed+that+it+was+active+against+S.+aureus.+The+scale+up+was+carried+out+in+an+Erlenmeyer+2+L+x+6+and+the+weight+was+6+grams.+The+results+of+the+scale+up+were+fractionated+by+open+column+chromatography.+The+fraction+with+less+stains+(F-24)+was+positive+for+the+reagent+(Ce2SO4)3+(RF+0.68+and+RF+0.7)%2C+Dragendorf+(RF+0.68+and+RF+0.8)%2C+and+Ninhydrin+(RF+0.68).+and+RF+0.7)+by+TLC+test.+F-24+has+antibacterial+activity+against+S.+aureus+at+a+concentration+of+450+g%2F%C2%B5L+with+an+inhibition+percentage+of+23.031%25.+The+fraction+is+predicted+to+have+the+molecular+formula+C38H48N9O6+with+m%2Fz+726+and+there+are+alkaloids+compound+and+peptide+compound.+Confirmed+by+FTIR+there+is+N-H+group+at+an+absorption+3272+cm-1%2C+a+C-H+group+at+an+absorption+of+2929+cm-1%2C+an+overtune+of+benzene+at+an+absorption+of+2079+cm-1%2C+and+a+C%3DN+group+at+an+absorption+of+1669+cm-1%2C+1602+cm-1+and+1535+cm-+1.%0D%0A%0D%0AKey+Word%3A+antibacterial%2C+fungi%2C+Aspergillus+nomiae%2C+Staphylococcus+aureus&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM+&rft.date=2022-09-02&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F66875%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F66875%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F66875%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++ZAHRAH+KHAIRANI%2C+1657011002++(2022)+ISOLASI+DAN+KARAKTERISASI+SENYAWA+BIOAKTIF+FUNGI+Aspergillus+nomiae+A12-RF+YANG+BERASOSIASI+DENGAN+SPONS+SEBAGAI+ANTIBAKTERI+TERHADAP+ISOLAT+KLINIS+Staphylococcus+aureus.++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM+%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F66875%2F