creators_name: Miranda, Alyzah Nabila
creators_id: 1818011032
type: other
datestamp: 2022-12-19 06:55:07
lastmod: 2022-12-19 06:55:07
metadata_visibility: show
title: PENGARUH KOMBINASI JUS PARE (Momordica charantia L.)
DAN JUS APEL (Malus domestica) TERHADAP KADAR
KOLESTEROL TOTAL PADA TIKUS PUTIH
(Rattus norvegicus) JANTAN GALUR
Sprague dawley YANG DIINDUKSI
DIET TINGGI LEMAK
ispublished: pub
subjects: 610
full_text_status: restricted
abstract: Latar Belakang: Hiperkolesterolemia merupakan faktor utama terjadinya
dislipidemia yang berperan utama dalam terjadinya aterosklerosis dan penyebab
terjadinya penyakit jantung koroner (PJK). Buah pare (Momordica charantia L.)
dan apel (Malus domestica) memiliki senyawa yang dapat menurunkan kadar
kolesterol.
Metode : Penelitian eksperimental dengan desain Post Test Only Control yang
dilakukan selama empat belas hari menggunakan 35 sampel berupa tikus putih
(Rattus norvegicus) jantan galur Sprague dawley yang dibagi menjadi lima
kelompok perlakuan yaitu KN hanya diberikan pakan standar, K- diberi induksi
kuning telur puyuh, P1, P2, dan P3 yang diinduksi kuning telur puyuh dan jus
buah pare (Momordica charantia L.) 3 ml/250grBB, buah apel (Malus domestica)
5 ml/250grBB dan kombinasi jus buah pare (Momordica charantia L.) dan apel
(Malus domestica) 8 ml/250grBB. Kemudian darah diambil dari ekor lalu
diperiksa kadar kolesterol total menggunakan Glucose Choletsterol Uric acid
(GCU) pada hari ke-15.
Hasil : Hasil uji One-Way ANOVA didapatkan kadar kolesterol total darah
menunjukkan nilai p 0.001 (p<0.05) yang artinya terdapat perbedaan yang
bermakna. Hasil uji post-hoc Tamhene pada kolesterol total kelompok K- terdapat
perbedaan yang bermakna dengan kelompok P1,P2, dan P3 (p<0.05).
Kesimpulan : Pemberian Jus pare (Momordica charantia L.) dan apel (Malus
domestica) dapat menurunkan kadar kolesterol total tikus yang diberi diet tinggi
lemak.
Kata Kunci : Dislipidemia, Kolesterol, Malus domestica, Momordica charantia
L.

Background: Hypercholesterolemia is a major factor in the occurrence of
dyslipidemia which plays a role in the occurrence of atherosclerosis and the cause
of coronary heart disease (CHD). Bitter melon (Momordica charantia L.) and
apple (Malus domestica) have compounds that can lower cholesterol levels.
Methods: Experimental research with Post Test Only Control design which was
carried out for fourteen days using 35 samples of male white rats (Rattus
norvegicus) Sprague dawley strain which were divided into five treatment groups,
namely KN were only given standard feed, K- was given quail egg yolk induction.
P1, P2, and P3 induced by quail egg yolk and bitter melon fruit juice (Momordica
charantia L.) 3 ml/250grBB, apple (Malus domestica) 5 ml/250grBB and a
combination of bitter melon fruit juice (Momordica charantia L.) and apple
(Malus domestica) 8 ml/250grBB. Then blood was taken from the tail and then
checked for total cholesterol levels using Glucose Choletsterol Uric acid (GCU)
on the 15th day.
Results: The results of the One-Way ANOVA test showed that total blood
cholesterol levels showed a p value of 0.001 (p< 0.05), which means that there
was a significant difference. The results of the post-hoc Tamhene test on total
cholesterol in the K- group were significantly different from the P1, P2, and P3
groups (p < 0.05).
Conclusion: The administration of bitter melon (Momordica charantia L.) and
apple (Malus domestica) juice can reduce total cholesterol levels in rats fed a
high-fat diet.
Keywords: Dyslipidemia, Cholesterol, Momordica charantia L., Malus
domestica,.
date: 2022-12-19
date_type: published
publisher: FAKULTAS KEDOKTERAN
place_of_pub: UNIVERSITAS LAMPUNG
id_number: 1818011032
citation:   Miranda, Alyzah Nabila  (2022) PENGARUH KOMBINASI JUS PARE (Momordica charantia L.) DAN JUS APEL (Malus domestica) TERHADAP KADAR KOLESTEROL TOTAL PADA TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR Sprague dawley YANG DIINDUKSI DIET TINGGI LEMAK.  FAKULTAS KEDOKTERAN, UNIVERSITAS LAMPUNG.     
document_url: http://digilib.unila.ac.id/67791/1/1.%20ABSTRAK.pdf
document_url: http://digilib.unila.ac.id/67791/2/2.%20SKRIPSI%20FULL.pdf
document_url: http://digilib.unila.ac.id/67791/3/3.%20SKRIPSI%20TANPA%20BAB%20PEMBAHASAN.pdf