%A   Fathurrahman Zain Muhamad 
%T PENGARUH PEMBERIAN EKSTRAK ETANOL 95% KULIT BATANG 
Rhizophora Apiculata TERHADAP KADAR PLASMA ENZIM Alanin 
Aminotransferase (ALT) dan Aspartat Aminotransferase (AST) TIKUS 
PUTIH JANTAN (Rattus norvegicus) GALUR Sprague Dawley YANG 
DIINDUKSI PARASETAMOL
%X Latar Belakang: Rhizophora Apiculata mengandung antioksidan alami yang 
berpengaruh dalam pencegahan kerusakan hati. Penelitian ini bertujuan untuk 
mengetahui efek pemberian ekstrak etanol 95% kulit batang Rhizopora apiculata 
pada tikus putih jantan yang diinduksi parasetamol.
Metode: Penelitian eksperimental dengan menggunakan posttest control only 
group design pada 30 tikus. Ada 6 kelompok, semua kelompok diinduksi 
parasetamol dosis 500 mg/kgBB/hari selama 15 hari kecuali kelompok KN hanya 
diberikan pakan standar, kelompok K- hanya diberikan parasetamol saja, kelompok 
K+ diberikan ekstrak kurkuma dosis 500 mg/kgBB/hari, dan kelompok P1, P2, P3 
masing masing diberikan ekstrak Rhizopora apiculata dengan masing-masing dosis 
14, 28, dan 56 mg/kgBB/Hari. Tikus diterminasi, pengambilan darah melalui 
intracardiac. Data dianalisis menggunakan uji normalitas dilanjutkan uji hipotesis 
komparatif dan uji lanjutan.
Hasil: Rerata kadar ALT pada KN (86,6 U/L), K+ (78 U/L), K- (114,4), P1 (92,8 
U/L), P2 (82,2 U/L), dan P3 (76,2 U/L). Rerata kadar AST pada KN (190,4 U/L), 
K+ (194 U/L), K- (262,8 U/L), P1 (201,8 U/L), P2 (178,8 U/L), dan P3 (151,6 U/L). 
Rerata kadar ALT dan AST pada kelompok perlakuan memiliki nilai p<0,05
dengan K?Simpulan: Pemberian ekstrak etanol 95% kulit batang Rhizopora apiculata dosis 
14, 28, dan 56 mg/kgBB/hari selama 15 hari dapat mencegah kerusakan hati tikus 
putih jantan yang diinduksi oleh parastamol dosis 500 mg/kgBB/hari. Pada dosis 
56 mg/kgBB/hari lebih baik efeknya dibandingkan dosis 14, 28 mg/kgBB/hari dan 
ekstrak kurkuma dosis 500 mg/kgBB/hari. 
Kata Kunci : ALT (Alanin Aminotransferase), AST (Aspartat Aminotransferase), 
dan Rhizopora apiculata


Background: Rhizophora apiculata contains natural antioxidants that are 
influential in preventing liver damage. This study aims to determine the effect of 
giving 95% ethanol extract of Rhizophora apiculata stem bark to male white rats 
induced by paracetamol.
Method: Experimental study using a post test control only group design on 30 rats. 
There were 6 groups, all groups were induced by paracetamol at a dose of 500 
mg/kgBW/day for 15 days except KN gorup was only given standard feed, then the
K- group was only given paracetamol, the K+ group was given curcumin extract 
dose of 500 mg/kgBW/day, and groups P1, P2, P3 were each given extract of 
Rhizopora apiculata at doses of 14, 28 and 56 mg/kgBW/day respectively. The rats 
were terminated, blood was collected via intracardiac. Data were analyzed using 
the normality test followed by comparative hypothesis testing and follow-up 
testing.
Result: The mean ALT levels in the KN group (86.6 U/L), K+ (78 U/L), K- (114.4),
P1 (92.8 U/L), P2 (82) .2 U/L), and P3 (76.2 U/L). The mean AST levels in the KN 
group (190.4 U/L), K+ (194 U/L), K- (262.8 U/L), P1 (201.8 U/L), P2 (178.8 U/L), 
and P3 (151.6 U/L). The mean ALT and AST levels in the treatment group were 
significantly different from the K- gorup with a p<0.05
Conclusion: Giving 95% ethanol extract of Rhizopora apiculata stem bark at doses 
of 14, 28, and 56 mg/kg/day for 15 days could prevent liver damage to male white 
rats induced by parastamol at a dose of 500 mg/kg/day. At a dose of 56 
mg/kgBW/day the effect was better than at a dose of 14.28 mg/kgBW/day and 
curcumin extract at a dose of 500 mg/kgBW/day.
Keyword: ALT (Alanin Aminotransferase), AST (Aspartat Aminotransferase), and 
Rhizopora apiculata


%D 2023
%C Universitas Lampung
%R 1958011021
%I Fakultas Kedokteran
%L eprints69454