?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+EKSTRAK+ETANOL+KULIT+BATANG%0D%0ABAKAU+MINYAK+(Rhizophora+apiculata)+TERHADAP+%0D%0AHISTOPATOLOGI+HEPAR+TIKUS+PUTIH+JANTAN+%0D%0A(Rattus+norvegicus)+GALUR+Sprague-Dawley+%0D%0AYANG+DIINDUKSI+PARASETAMOL%0D%0A&rft.creator=Sulthan+%2C+Alam+Yasyfa+&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=ABSTRACT%0D%0A+%0D%0ATHE+EFFECT+OF+GIVING+ETHANOL+EXTRACTS+OF+MANGROVE+OIL%0D%0A(Rhizophora+apiculata)+STEMS+ON+HEPARAL+HISTOPATOLOGY+OF%0D%0AMALE+WHITE+RATS+(Rattus+norvegicus)+Sprague-Dawley+strain%0D%0APARACETAMOLE+INDUCED%0D%0A+%0D%0ABy%0D%0ASULTHAN+ALAM+YASYFA%0D%0A+%0D%0ABackground%3A+The+liver+is+one+of+the+organs+that+plays+a+role+in+the+detoxification%0D%0Aprocess+thereby+protecting+the+body+from+potentially+toxic+chemicals+such+as%0D%0Adrugs.+One+of+the+drugs+that+can+cause+drug-induced+liver+injury+is+paracetamol.%0D%0APrevention+of+liver+damage+by+paracetamol+can+be+done+by+consuming+ingredients%0D%0Athat+have+protective+effects%2C+one+of+which+is+mangrove+oil+Rhizpora+apiculata+.%0D%0AThe+aim+of+this+study+was+to+determine+the+effect+of+administration+of+ethanol%0D%0Aextract+of+mangrove+oil+(Rhizophora+apiculata)+stem+bark+on+the+histopathological%0D%0Aappearance+of+the+liver+of+male+white+rats+(Rattus+norvegicus)+Sprague-Dawley%0D%0Astrain+induced+by+paracetamol.%0D%0AMethods%3A+This+research+is+a+laboratory+experimental+study+using+a+randomized%0D%0Acontrolled+design+with+a+post+test+only+control+group+design.+The+research+subjects%0D%0Awere+30+adult+Sprague-Dawley+rats+aged+10-12+weeks.+The+results+of+this+study%0D%0Awere+the+histopathological+picture+of+the+liver+of+male+white+rats+(Rattus%0D%0Anorvegicus)+Sprague-Dawley+strain+induced+by+paracetamol+which+was+influenced%0D%0Aby+the+administration+of+ethanol+extract+of+oil-mangrove+stem+bark+(Rhizophora%0D%0Aapiculata).+Statistical+analysis+using+Kruskal+Wallis+using+Post+Hoc%0D%0AMannWhitney.%0D%0AResults%3A+In+the+phytochemical+test%2C+the+bark+extract+of+mangrove+oil+proved+to%0D%0Acontain+saponins%2C+tannins%2C+terpenoids%2C+and+flavonoids.+Hepatic+damage+scoring%0D%0Aobtained+at+KN%3D2.56%2C+K-+%3D+5.16%2C+K%2B+%3D+2.92%2C+P1%3D3.72%2C+P2%3D2.76%2C+P3%3D2.12.+The%0D%0Aresults+of+the+Kruskal+Wallis+analysis+and+followed+by+the+Post+Hoc+MannWhitney%0D%0Afound+a+significant+difference+in+the+mean+between+the+K-+and+P1%2C+P2+and+P3%0D%0Agroups+(p%3D0%2C003).%0D%0AConclusion%3A+There+is+an+effect+of+administration+of+ethanol+extract+of+oil%0D%0Amangrove+stem+bark+(Rhizophora+apiculata)+on+the+histopathological+appearance%0D%0Aof+the+liver+of+male+white+rats+(Rattus+norvegicus)+Sprague-Dawley+strain+induced%0D%0Aby+paracetamol.%0D%0A%0D%0A%0D%0AKeywords%3A+Liver%2C+histopathology%2C+Rhizophora+apiculata%0D%0A+%0D%0AABSTRAK%0D%0A+%0D%0APENGARUH+PEMBERIAN+EKSTRAK+ETANOL+KULIT+BATANG%0D%0ABAKAU+MINYAK+(Rhizophora+apiculata)+TERHADAP+%0D%0AHISTOPATOLOGI+HEPAR+TIKUS+PUTIH+JANTAN+%0D%0A(Rattus+norvegicus)+GALUR+Sprague-Dawley+%0D%0AYANG+DIINDUKSI+PARASETAMOL%0D%0A+%0D%0AOleh%0D%0ASULTHAN+ALAM+YASYFA%0D%0A+%0D%0ALatar+Belakang%3A+Hepar+adalah+salah+satu+organ+yang+berperan+dalam+proses%0D%0Adetoksifikasi+sehingga+melindungi+tubuh+dari+bahan+kimia+yang+berpotensi+toksik%0D%0Aseperti+obat.+Salah+satu+obat+yang+dapat+menyebabkan+drug-induced+liver+injury%0D%0Aadalah+parasetamol.+Pencegahan+kerusakan+hepar+oleh+parasetamol+dapat%0D%0Adilakukan+dengan+mengkonsumsi+bahan+yang+memiliki+khasiat+efek+protektif%2C%0D%0Asalah+satunya+bakau+minyak+Rhizpora+apiculata+.+Tujuan+penelitian+ini+adalah%0D%0Auntuk+mengetahui++pengaruh+pemberian+ekstrak+etanol+kulit+batang+bakau+minyak%0D%0A(Rhizophora+apiculata)+terhadap+gambaran+histopatologi+hepar+tikus+putih+jantan%0D%0A(Rattus+norvegicus)+galur+Sprague-Dawley+yang+diinduksi+parasetamol.%0D%0AMetode%3A+Penelitian+ini+merupakan+penelitian+eksperimental+laboratorik+yang%0D%0Amenggunakan+metode+rancangan+acak+terkontrol+dengan+rancangan+post+test+only%0D%0Acontrol+group+design.+Subjek+penelitian+yaitu+tikus+galur+Sprague-Dawley+dewasa%0D%0Aberumur+10-12+minggu+sebanyak+30+ekor.+Hasil+penelitian+ini+adalah+gambaran%0D%0Ahistopatologi+hepar+tikus+putih+jantan+(Rattus+norvegicus)+galur+Sprague-Dawley%0D%0Ayang+diinduksi+parasetamol+yang+dipengaruhi+pemberian+ekstrak+etanol+kulit%0D%0Abatang+bakau+minyak+(Rhizophora+apiculata).+Analisis+statistik+menggunakan%0D%0AKruskal+Wallis+dengan+menggunakan+Post+Hoc+MannWhitney.%0D%0AHasil%3A+Pada+uji+fitokimia+ekstrak+kulit+batang+bakau+minyak+terbukti+mengandung%0D%0Asaponin%2C+tanin%2C+terpenoid%2C+dan+flavonoid.+Skoring+kerusakan+hepar+yang%0D%0Adidapatkan+pada+KN%3D2.56%2C+K-+%3D+5.16%2C+K%2B+%3D+2.92%2C+P1%3D3.72%2C+P2%3D2.76%2C+P3%3D2.12.%0D%0AHasil+analisis+Kruskal+Wallis+dan+dilanjutkan+dengan+Post+Hoc+MannWhitney%0D%0Aterdapat+perbedaan+rerata+yang+bermakna+antara+kelompok+K-+dengan+P1%2C+P2+dan%0D%0AP3+(p%3D0%2C003).%0D%0AKesimpulan%3A+Terdapat+pengar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