?url_ver=Z39.88-2004&rft_id=1958011015&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=ANALISIS+RISIKO+KARSINOMA+MAMMAE+BERDASARKAN+RIWAYAT+PEMAKAIAN+KONTRASEPSI+HORMONAL+DAN+USIA+MENARCHE+DI+RSUD+DR.+H.+ABDUL+MOELOEK+PROVINSI+LAMPUNG+TAHUN+2022%0D%0A&rft.creator=Ona%2C+Rahmawati&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Latar+belakang%3A+World+Health+Organization+(WHO)+mengemukakan+bahwa+pada+2020+terdapat+sejumlah+2%2C3+juta+perempuan+yang+terdiagnosa+karsinoma+mammae+dan+685.000+angka+kematian+secara+global.+Faktor+risiko+karsinoma+mammae+yang+tidak+dapat+termodifikasi+antara+lain+riwayat+pemakaian+estrogen%2C+endogen+tinggi%2C+terapi+hormon%2C+obesitas%2C+serta+konsumsi+alkohol+atau+paparan+bahan+kimia+.+Salah+satu+faktor+yang+menyebabkan+terpaparnya+hormon+estrogen+adalah+pemakaian+alat+kontrasepsi.+Paparan+estrogen+didapatkan+juga+sejak+menarche%2C+perempuan+dengan+usia+menarche+yang+terlalu+dini%2C+yaitu+kurang+dari+dua+belas+tahun.+Hal+tersebut+menimbulkan+paparan+hormon+estrogen+pada+tubuh+lebih+dini+dan+berkontribusi+dalam+faktor+risiko+terhadap+karsinoma+mammae.+%0D%0ATujuan%3A+Penelitian+ini+bertujuan+untuk+mengetahui+jumlah+kejadian+karsinoma+mammae+sepanjang+tahun+2022%2C+gambaran+pemakaian+kontrasepsi+hormonal+dan+usia+menarche%2C+besar+risiko+pemakaian+kontrasepsi+hormonal+dan+usia+menarche%2C+serta+besar+risiko+usia+menarche+terhadap+kejadian+karsinoma+mammae+di+di+RSUD+Dr.+H.+Abdul+Moeloek.%0D%0AMetode%3A+Penelitian+ini+menggunakan+rancangan+analitik+observasional+dengan+desain+penelitian+case+control++yang+bersifat+retrospektif.+Sampel+penelitian+dilakukan+secara+consecutive+sampling+dengan+minimal+sampel+seluruh+kelompok+adalah+172+responden+di+RSUD+Dr.+H.+Abdul+Moeloek+Provinsi+Lampung.+%0D%0AHasil%3A+Hasil+uji+chi-square+menunjukkan+adanya+hubungan+bermakna+antara+karsinoma+mammae+terhadap+riwayat+pemakaian+kontrasepsi+hormonal+(p-value+0%2C005)+dan+usia+menarche+dini+(p-value+0%2C031).+%0D%0AKesimpulan+%3A+Karsinoma+mammae+memiliki+hubungan+signifikan+dengan+riwayat+pemakaian+kontrasepsi+hormonal+dan+usia+menarche.%0D%0A%0D%0AKata+kunci+%3A+karsinoma+mammae%2C+kontrasepsi+hormonal%2C+menarche+dini.%0D%0A%0D%0A%0D%0ABackground%3A+World+Health+Organization+(WHO)+stated+by+the+year+of+2020%2C+2%2C3+million+females+confirmed+to+be+diagnosed+with+mammae+carcinoma+with+an+increasing+number+of+deaths+to+685.000+cases+globally.+Unmodified+risk+factors+of+mammae+carcinoma+are+history+of+hormonal+contraceptive+usage%2C+high+level+of+endogen%2C+hormonal+therapy%2C+obesity%2C+and+alcohol+intake+or+chemical+material+exposure.+One+of+the+factors+that+causes+the+exposure+of+estrogen+is+usage+of+hormonal+contraceptive.+It+started+as+the+menarche+occurs.+Female+with+the+earlier+age+of+menarche%2C+by+the+age+of+less+than+12+years+old%2C+may+lead+to+earlier+exposure+of+estrogen+that+contributes+as+a+risk+factor+of+mammae+carcinoma+%0D%0APurpose%3A+This+study+aims+to+acknowledge+the+prevalence+of+mammae+carcinoma+during+2022%2C+the+representation+of+hormonal+contraceptive+and+age+of+menarche%2C+and+calculating+the+risk+of+mammae+carcinoma+based+on+hormonal+contraceptive+use+and+early+age+of+menarche+in+RSUD+Dr.+H.+Abdul+Moeloek+Provinsi+Lampung.%0D%0AMethods+%3A+This+study+using+observational+analytic+approach+with+retrospective+case-control+study.+Study+sample+was+taken+with+consecutive+sampling%2C+the+minimum+sample+is+172+respondents+in+RSUD+Dr.+H.+Abdul+Moeloek+Provinsi+Lampung.+%0D%0AResults%3A+Chi-square+test+represents+that+there+are+significant+relation+of+carcinoma+mammae+and+the+use+of+hormonal+contraceptive+(p-value+0%2C005)+and+the+early+age+of+menarche+(p-value+0%2C031)%0D%0AConclusions%3A+Mammae+carcinoma+has+significant+relation+towards+the+use+of+hormonal+contraceptive+and+early+age+of+menarche%0D%0A%0D%0AKeyword%3A+early+menarche%2C+hormonal+contraceptive%2C+mammae+carcinoma.%0D%0A&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2023-02-06&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F69483%2F1%2F1.%2520ABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F69483%2F2%2F2.%2520SKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F69483%2F3%2F3.%2520SKRIPSI%2520TANPA%2520PEMBAHASAN.pdf&rft.identifier=++Ona%2C+Rahmawati++(2023)+ANALISIS+RISIKO+KARSINOMA+MAMMAE+BERDASARKAN+RIWAYAT+PEMAKAIAN+KONTRASEPSI+HORMONAL+DAN+USIA+MENARCHE+DI+RSUD+DR.+H.+ABDUL+MOELOEK+PROVINSI+LAMPUNG+TAHUN+2022.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F69483%2F