?url_ver=Z39.88-2004&rft_id=1857011005&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=EKSTRAKSI%2C+UJI+AKTIVITAS%2C+DAN+KARAKTERISASI+DAUN+DURIAN%0D%0A(Durio+zibethinus+Murr.)+SEBAGAI+ANTIDIABETES+TERHADAP+KADAR%0D%0AGLUKOSA+DARAH+MENCIT+(Mus+musculus+L.)+SECARA+IN+VIVO+DAN%0D%0AIN+SILICO+TANIN+PADA+PROTEIN+5DI1&rft.creator=Eni+Asro+Dzulhijjah++%2C+1857011005&rft.subject=000+Ilmu+komputer%2C+informasi+dan+pekerjaan+umum&rft.subject=001+Ilmu+pengetahuan&rft.description=ABSTRAK%0D%0A%0D%0AIsolasi+dan+identifikasi+senyawa+tanin+dari+daun+durian+(Durio+zibethinus+Murr.)%0D%0Aserta+uji+aktivitas+antidiabetes+terhadap+mencit+jantan+(Mus+musculus+L.)+secara+in%0D%0Avivo+dan+in+silico+telah+dilakukan+dalam+penelitian+ini.+Maserasi+menghasilkan%0D%0A51%2C8+g+ekstrak+pekat+metanol.+Uji+fitokimia+ekstrak+memberikan+hasil+positif%0D%0Amengandung+senyawa+tanin.+Partisi+menghasilkan+fraksi+n-heksana+dan+metanol.%0D%0APemisahan+secara+kromatografi+preparatif+dengan+eluen+n-butanol%3A+asam+asetat%3A+air%0D%0A(4%3A1%3A5)+diperoleh+1+pita.+Identifikasi+menggunakan+spektrofotometer+UV-Vis%0D%0Amemberikan+satu+puncak+dengan+serapan+maksimum+pada+panjang+gelombang%0D%0A229+nm+oleh+adanya+transisi+elektron+n%EF%82%AE%CF%80+*+dan+%CF%80%EF%82%AE%CF%80+*.+Transisi+ini%0D%0Amenunjukkan+adanya+kromofor+C%3DO+dan+C%3DC.+Spektrum+inframerah+isolat%0D%0Amenunjukkan+puncak+yang+sesuai+dengan+gugus+fungsi+karakteristik+tanin+yaitu+-%0D%0AO-H+(3324%2C8+cm-1)%2C+C-H+(2944%2C6+cm-1)%2C+C%3DO+(1625%2C8+cm-1)%2C+C%3DC+(1446%2C2+cm-1)%2C%0D%0Adan+C-O-C+(1118%2C2+cm-1).+Hasil+uji+aktivitas+antidiabetes+terhadap+mencit+jantan%0D%0A(Mus+musculus+L.)+dengan+dosis+terbaik+yaitu+400+mg%2FKgBB.+Uji+in+silico%0D%0Amenunjukan+bahwa+senyawa+galokatekol+dari+turunan+tanin+sebagai+penghambat%0D%0Aprotein+diabetes%2C+hasil+interaksi+ligan+galokatekol+berinteraksi+dengan+asam+amino%0D%0AMET+105+dan+GLU+106+dengan+energi+ikatan+-8.23+kkal%2Fmol.%0D%0AKata+kunci+%3A+Daun+Durian+(Durio+zibethinus+Murr.)%2C+Tanin%2C+Antidiabetes%2C+Mencit%0D%0AJantan+(Mus+musculus+L)%2C+Docking.%0D%0A%0D%0AIsolation+and+identification+of+tannin+compounds+from+durian+leaves+(Durio%0D%0Azibethinus+Murr.)+and+testing+of+anti-diabetic+activity+against+male+mice+(Mus%0D%0Amusculus+L.)+in+vivo+and+in+silico+have+been+carried+out+in+this+study.+Maceration%0D%0Aproduces+51.8+g+of+concentrated+methanol+extract.+The+phytochemical+test+of+the%0D%0Aextract+gave+positive+results+for+containing+tannin+compounds.+Partitioning%0D%0Aproduces+n-hexane+and+methanol+fractions.+Separation+by+preparative%0D%0Achromatography+with+eluent+n-butanol%3A+acetic+acid%3A+water+(4%3A1%3A5)+obtained+1+band.%0D%0AIdentification+using+a+UV-Vis+spectrophotometer+gives+a+peak+with+maximum%0D%0Aabsorption+at+a+wavelength+of+229+nm+by+the+presence+of+electron+transitions+n%EF%82%AE%CF%80%0D%0A*+and+%CF%80%EF%82%AE%CF%80+*.+This+transitions+indicating+the+presence+of+C%3DO+and+C%3DC%0D%0Achromophores.+The+infrared+spectrum+of+the+isolate+showed+peaks+corresponding%0D%0Ato+the+characteristic+functional+groups+of+tannins%2C+namely+-O-H+(3324.8+cm-1)%2C+CH%0D%0A(2944.6+cm-1)%2C+C%3DO+(1625.8+cm-1)%2C+C%3DC+(+1446.2+cm-1)%2C+and+C-O-C+(1118.2%0D%0Acm-1).+The+results+of+the+antidiabetic+activity+test+on+male+mice+(Mus+musculus%0D%0AL.)+with+the+best+dose+of+400+mg%2FKgBW.+The+in+silico+test+showed+that+the%0D%0Agalocatecol+compound+from+tannin+derivatives+acts+as+an+inhibitor+for+diabetes%0D%0Aprotein%2C+the+result+of+the+interaction+of+galocatecol+ligands+interacts+with+the+amino%0D%0Aacids+MET+105+and+GLU+106+with+a+bond+energy+of+-8.23+kcal%2Fmol.%0D%0AKeywords%3A+Durian+leaves+(Durio+zibethinus+Murr.)%2C+Tannins%2C+Antidiabetic%2C+Male%0D%0AMice+(Mus+musculus+L.)%2C+Docking.&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2023-01-26&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F70057%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F70057%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F70057%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Eni+Asro+Dzulhijjah+%2C+1857011005++(2023)+EKSTRAKSI%2C+UJI+AKTIVITAS%2C+DAN+KARAKTERISASI+DAUN+DURIAN+(Durio+zibethinus+Murr.)+SEBAGAI+ANTIDIABETES+TERHADAP+KADAR+GLUKOSA+DARAH+MENCIT+(Mus+musculus+L.)+SECARA+IN+VIVO+DAN+IN+SILICO+TANIN+PADA+PROTEIN+5DI1.++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM%2C+UNIVERSITAS+LAMPUNG.++++(Submitted)++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F70057%2F